Potassium-transporting ATPase subunit beta
Details
- Name
- Potassium-transporting ATPase subunit beta
- Synonyms
- Gastric H(+)/K(+) ATPase subunit beta
- Proton pump beta chain
- Gene Name
- ATP4B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010431|Potassium-transporting ATPase subunit beta MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLY VLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGY SPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFI IKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPH YSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
- Number of residues
- 291
- Molecular Weight
- 33366.95
- Theoretical pI
- 7.37
- GO Classification
- FunctionshydrogenProcessescell adhesion / hydrogen ion transmembrane transport / ion transmembrane transport / response to lipopolysaccharide / response to organonitrogen compound / sodium ion transport / transmembrane transportComponentsplasma membrane / sodium
- General Function
- Hydrogen:potassium-exchanging atpase activity
- Specific Function
- Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity.
- Pfam Domain Function
- Na_K-ATPase (PF00287)
- Transmembrane Regions
- 37-57
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010432|Potassium-transporting ATPase subunit beta (ATP4B) ATGGCGGCTCTGCAGGAGAAGAAGACGTGTGGCCAGCGCATGGAGGAGTTCCAGCGTTAC TGCTGGAACCCGGACACGGGGCAGATGCTGGGCCGCACCCTGTCCCGGTGGGTGTGGATC AGCCTGTACTACGTGGCCTTCTACGTGGTGATGACTGGGCTCTTCGCCCTGTGCCTCTAT GTGCTGATGCAGACAGTGGACCCGTACACACCGGACTACCAAGACCAGCTACGGTCACCA GGGGTAACCTTAAGGCCGGATGTTTACGGGGAGAAAGGCCTGGAAATTGTCTACAACGTC TCTGATAACAGAACCTGGGCAGACCTCACACAGACTCTCCACGCCTTCCTAGCAGGCTAC TCTCCAGCAGCCCAGGAGGACAGCATCAACTGCACCTCCGAGCAGTACTTCTTCCAGGAG AGTTTCCGCGCTCCCAACCACACCAAGTTCTCCTGCAAGTTCACGGCAGATATGCTGCAG AACTGCTCAGGCCTGGCGGATCCCAACTTCGGCTTTGAAGAAGGAAAGCCATGTTTTATT ATTAAAATGAACAGGATCGTCAAGTTCCTCCCCAGCAACGGCTCGGCCCCCAGAGTGGAC TGCGCCTTCCTGGACCAGCCCCGCGAGCTCGGCCAGCCGCTGCAGGTCAAGTACTACCCT CCCAACGGCACCTTCAGTCTGCACTACTTCCCTTATTACGGGAAGAAAGCCCAGCCCCAC TACAGCAACCCCCTGGTGGCAGCGAAGCTCCTCAACATCCCCAGGAACGCTGAGGTCGCC ATCGTGTGCAAGGTCATGGCGGAGCACGTGACCTTCAACAATCCCCACGACCCGTATGAA GGGAAAGTGGAGTTCAAACTCAAGATTGAGAAGTGA
- Chromosome Location
- 13
- Locus
- 13q34
- External Identifiers
Resource Link UniProtKB ID P51164 UniProtKB Entry Name ATP4B_HUMAN GenBank Protein ID 184105 GenBank Gene ID M75110 GenAtlas ID ATP4B HGNC ID HGNC:820 - General References
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- Yoshida T, Sato R, Mahmood S, Kawasaki S, Futai M, Maeda M: GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells. FEBS Lett. 1997 Sep 8;414(2):333-7. [Article]
- Bab-Dinitz E, Albeck S, Peleg Y, Brumfeld V, Gottschalk KE, Karlish SJ: A C-terminal lobe of the beta subunit of Na,K-ATPase and H,K-ATPase resembles cell adhesion molecules. Biochemistry. 2009 Sep 15;48(36):8684-91. doi: 10.1021/bi900868e. [Article]