Matrix metalloproteinase-15
Details
- Name
- Matrix metalloproteinase-15
- Synonyms
- 3.4.24.-
- Membrane-type matrix metalloproteinase 2
- Membrane-type-2 matrix metalloproteinase
- MMP-15
- MT-MMP 2
- MT2-MMP
- MT2MMP
- MTMMP2
- SMCP-2
- Gene Name
- MMP15
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007094|Matrix metalloproteinase-15 MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLY GYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVR VKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQ EVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEP WTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQ QLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATE RPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDIS AAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFF FQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNE RLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGD FGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLY CKRSLQEWV
- Number of residues
- 669
- Molecular Weight
- 75806.45
- Theoretical pI
- 7.49
- GO Classification
- Functionscalcium ion binding / enzyme activator activity / metalloendopeptidase activity / zinc ion bindingProcessescellular protein modification process / collagen catabolic process / endodermal cell differentiation / extracellular matrix disassembly / extracellular matrix organization / positive regulation of catalytic activity / response to estradiolComponentsextracellular matrix / integral component of plasma membrane / plasma membrane
- General Function
- Zinc ion binding
- Specific Function
- Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.
- Pfam Domain Function
- Transmembrane Regions
- 626-646
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0020708|Matrix metalloproteinase-15 (MMP15) ATGGGCAGCGACCCGAGCGCGCCCGGACGGCCGGGCTGGACGGGCAGCCTCCTCGGCGAC CGGGAGGAGGCGGCGCGGCCGCGACTGCTGCCGCTGCTCCTGGTGCTTCTGGGCTGCCTG GGCCTTGGCGTAGCGGCCGAAGACGCGGAGGTCCATGCCGAGAACTGGCTGCGGCTTTAT GGCTACCTGCCTCAGCCCAGCCGCCATATGTCCACCATGCGTTCCGCCCAGATCTTGGCC TCGGCCCTTGCAGAGATGCAGCGCTTCTACGGGATCCCAGTCACCGGTGTGCTCGACGAA GAGACCAAGGAGTGGATGAAGCGGCCCCGCTGTGGGGTGCCAGACCAGTTCGGGGTACGA GTGAAAGCCAACCTGCGGCGGCGTCGGAAGCGCTACGCCCTCACCGGGAGGAAGTGGAAC AACCACCATCTGACCTTTAGCATCCAGAACTACACGGAGAAGTTGGGCTGGTACCACTCG ATGGAGGCGGTGCGCAGGGCCTTCCGCGTGTGGGAGCAGGCCACGCCCCTGGTCTTCCAG GAGGTGCCCTATGAGGACATCCGGCTGCGGCGACAGAAGGAGGCCGACATCATGGTACTC TTTGCCTCTGGCTTCCACGGCGACAGCTCGCCGTTTGATGGCACCGGTGGCTTTCTGGCC CACGCCTATTTCCCTGGCCCCGGCCTAGGCGGGGACACCCATTTTGACGCAGATGAGCCC TGGACCTTCTCCAGCACTGACCTGCATGGAAACAACCTCTTCCTGGTGGCAGTGCATGAG CTGGGCCACGCGCTGGGGCTGGAGCACTCCAGCAACCCCAATGCCATCATGGCGCCGTTC TACCAGTGGAAGGACGTTGACAACTTCAAGCTGCCCGAGGACGATCTCCGTGGCATCCAG CAGCTCTACGGTACCCCAGACGGTCAGCCACAGCCTACCCAGCCTCTCCCCACTGTGACG CCACGGCGGCCAGGCCGGCCTGACCACCGGCCGCCCCGGCCTCCCCAGCCACCACCCCCA GGTGGGAAGCCAGAGCGGCCCCCAAAGCCGGGCCCCCCAGTCCAGCCCCGAGCCACAGAG CGGCCCGACCAGTATGGCCCCAACATCTGCGACGGGGACTTTGACACAGTGGCCATGCTT CGCGGGGAGATGTTCGTGTTCAAGGGCCGCTGGTTCTGGCGAGTCCGGCACAACCGCGTC CTGGACAACTATCCCATGCCCATCGGGCACTTCTGGCGTGGTCTGCCCGGTGACATCAGT GCTGCCTACGAGCGCCAAGACGGTCGTTTTGTCTTTTTCAAAGGTGACCGCTACTGGCTC TTTCGAGAAGCGAACCTGGAGCCCGGCTACCCACAGCCGCTGACCAGCTATGGCCTGGGC ATCCCCTATGACCGCATTGACACGGCCATCTGGTGGGAGCCCACAGGCCACACCTTCTTC TTCCAAGAGGACAGGTACTGGCGCTTCAACGAGGAGACACAGCGTGGAGACCCTGGGTAC CCCAAGCCCATCAGTGTCTGGCAGGGGATCCCTGCCTCCCCTAAAGGGGCCTTCCTGAGC AATGACGCAGCCTACACCTACTTCTACAAGGGCACCAAATACTGGAAATTCGACAATGAG CGCCTGCGGATGGAGCCCGGCTACCCCAAGTCCATCCTGCGGGACTTCATGGGCTGCCAG GAGCACGTGGAGCCAGGCCCCCGATGGCCCGACGTGGCCCGGCCGCCCTTCAACCCCCAC GGGGGTGCAGAGCCCGGGGCGGACAGCGCAGAGGGCGACGTGGGGGATGGGGATGGGGAC TTTGGGGCCGGGGTCAACAAGGACGGGGGCAGCCGCGTGGTGGTGCAGATGGAGGAGGTG GCACGGACGGTGAACGTGGTGATGGTGCTGGTGCCACTGCTGCTGCTGCTCTGCGTCCTG GGCCTCACCTACGCGCTGGTGCAGATGCAGCGCAAGGGTGCGCCACGTGTCCTGCTTTAC TGCAAGCGCTCGCTGCAGGAGTGGGTCTGA
- Chromosome Location
- 16
- Locus
- 16q13-q21
- External Identifiers
Resource Link UniProtKB ID P51511 UniProtKB Entry Name MMP15_HUMAN GenBank Protein ID 963056 GenBank Gene ID Z48482 HGNC ID HGNC:7161 - General References
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