Serine/threonine-protein kinase Nek4
Details
- Name
- Serine/threonine-protein kinase Nek4
- Synonyms
- 2.7.11.1
- Never in mitosis A-related kinase 4
- NimA-related protein kinase 4
- Serine/threonine-protein kinase 2
- Serine/threonine-protein kinase NRK2
- STK2
- Gene Name
- NEK4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051874|Serine/threonine-protein kinase Nek4 MPLAAYCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQL KHPNIVTYKESWEGGDGLLYIVMGFCEGGDLYRKLKEQKGQLLPENQVVEWFVQIAMALQ YLHEKHILHRDLKTQNVFLTRTNIIKVGDLGIARVLENHCDMASTLIGTPYYMSPELFSN KPYNYKSDVWALGCCVYEMATLKHAFNAKDMNSLVYRIIEGKLPPMPRDYSPELAELIRT MLSKRPEERPSVRSILRQPYIKRQISFFLEATKIKTSKNNIKNGDSQSKPFATVVSGEAE SNHEVIHPQPLSSEGSQTYIMGEGKCLSQEKPRASGLLKSPASLKAHTCKQDLSNTTELA TISSVNIDILPAKGRDSVSDGFVQENQPRYLDASNELGGICSISQVEEEMLQDNTKSSAQ PENLIPMWSSDIVTGEKNEPVKPLQPLIKEQKPKDQSLALSPKLECSGTILAHSNLRLLG SSDSPASASRVAGITGVCHHAQDQVAGECIIEKQGRIHPDLQPHNSGSEPSLSRQRRQKR REQTEHRGEKRQVRRDLFAFQESPPRFLPSHPIVGKVDVTSTQKEAENQRRVVTGSVSSS RSSEMSSSKDRPLSARERRRLKQSQEEMSSSGPSVRKASLSVAGPGKPQEEDQPLPARRL SSDCSVTQERKQIHCLSEDELSSSTSSTDKSDGDYGEGKGQTNEINALVQLMTQTLKLDS KESCEDVPVANPVSEFKLHRKYRDTLILHGKVAEEAEEIHFKELPSAIMPGSEKIRRLVE VLRTDVIRGLGVQLLEQVYDLLEEEDEFDREVRLREHMGEKYTTYSVKARQLKFFEENMN F
- Number of residues
- 841
- Molecular Weight
- 94596.4
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / manganese ion binding / protein serine/threonine kinase activityProcessesactivation of protein kinase activity / cell division / cellular response to DNA damage stimulus / mitotic cell cycle / positive regulation of transcription, DNA-templated / protein phosphorylation / regulation of apoptotic process / regulation of cellular senescence / regulation of mitotic cell cycle / regulation of replicative cell aging / regulation of response to DNA damage stimulus / signal transduction by protein phosphorylation / stress-activated protein kinase signaling cascadeComponentsciliary basal body / ciliary plasm / ciliary rootlet / ciliary transition zone / cytoplasm / cytosol
- General Function
- Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage.
- Specific Function
- Atp binding
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell projection
- Gene sequence
>lcl|BSEQ0051875|Serine/threonine-protein kinase Nek4 (NEK4) ATGCCCCTGGCCGCCTACTGCTACCTGCGGGTCGTGGGCAAGGGGAGCTATGGAGAGGTG ACGCTTGTGAAGCACCGGCGGGACGGCAAGCAGTATGTCATCAAAAAACTGAACCTCCGA AATGCCTCTAGCCGAGAGCGGCGAGCTGCTGAACAGGAAGCCCAGCTCTTGTCTCAGTTG AAGCATCCCAACATTGTCACCTACAAGGAGTCATGGGAAGGAGGAGATGGTCTGCTCTAC ATTGTCATGGGCTTCTGTGAAGGAGGTGATTTGTACCGAAAGCTCAAGGAGCAGAAAGGG CAGCTTCTGCCTGAGAATCAGGTGGTAGAGTGGTTTGTACAGATCGCCATGGCTTTGCAG TATTTACATGAAAAACACATCCTTCATCGAGATCTGAAAACTCAAAATGTCTTCCTAACA AGAACAAACATCATCAAAGTAGGGGACCTAGGAATTGCCCGAGTGTTAGAGAACCACTGT GACATGGCTAGCACCCTCATTGGCACACCCTACTACATGAGCCCTGAATTGTTCTCAAAC AAACCCTACAACTATAAGTCTGATGTTTGGGCTCTAGGATGCTGTGTCTATGAAATGGCC ACCTTGAAGCATGCTTTCAATGCAAAAGATATGAATTCTTTAGTTTATCGGATTATTGAA GGAAAGCTGCCACCAATGCCAAGAGATTACAGCCCAGAGCTGGCAGAACTGATAAGAACA ATGCTGAGCAAAAGGCCTGAAGAAAGGCCGTCTGTGAGGAGCATCCTGAGGCAGCCTTAT ATAAAGCGGCAAATCTCCTTCTTTTTGGAGGCCACAAAGATAAAAACCTCCAAAAATAAC ATTAAAAATGGTGACTCTCAATCCAAGCCTTTTGCTACAGTGGTTTCTGGAGAGGCAGAA TCAAATCATGAAGTAATCCACCCCCAACCACTCTCTTCTGAGGGCTCCCAGACATATATA ATGGGTGAAGGCAAATGTTTGTCCCAGGAGAAACCCAGGGCCTCTGGTCTCTTGAAGTCA CCTGCCAGTCTGAAAGCCCATACCTGCAAACAGGACTTGAGCAATACCACAGAACTAGCC ACAATCAGTAGCGTAAATATTGACATCTTACCTGCAAAAGGGAGGGATTCAGTGAGTGAT GGCTTTGTTCAGGAGAATCAGCCAAGATATTTGGATGCCTCTAATGAGTTAGGAGGTATA TGCAGTATTTCTCAAGTGGAAGAGGAGATGCTGCAGGACAACACTAAATCCAGTGCCCAG CCTGAAAACCTGATTCCCATGTGGTCCTCTGACATTGTCACTGGGGAAAAGAATGAACCA GTGAAGCCTCTGCAGCCCCTAATCAAAGAACAAAAGCCAAAGGACCAGAGTCTTGCCCTG TCGCCCAAGCTGGAGTGCAGTGGCACAATCTTGGCTCACAGCAACCTCCGCCTCCTGGGT TCAAGTGATTCTCCAGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCGTGTGCCACCAC GCCCAGGATCAAGTTGCTGGTGAATGTATTATAGAAAAACAGGGCAGAATCCACCCAGAT TTACAGCCACACAACTCTGGGTCTGAACCTTCCCTGTCTCGACAGCGACGGCAAAAGAGG AGAGAACAGACTGAGCACAGAGGGGAAAAGAGACAGGTCCGCAGAGATCTCTTTGCTTTC CAAGAGTCGCCTCCTCGATTTTTGCCTTCTCATCCCATTGTTGGGAAAGTGGATGTCACA TCAACACAAAAAGAGGCTGAAAACCAACGTAGAGTGGTCACTGGGTCTGTGAGCAGTTCA AGGAGCAGTGAGATGTCATCATCAAAGGATCGACCATTATCAGCCAGAGAGAGGAGGCGA CTAAAGCAGTCACAGGAAGAAATGTCCTCTTCAGGCCCTTCAGTGAGGAAAGCGTCTCTG AGTGTAGCAGGGCCAGGAAAACCCCAGGAAGAAGACCAGCCCTTGCCTGCCCGACGGCTC TCCTCTGACTGCAGCGTCACTCAGGAAAGGAAACAGATTCATTGTCTGTCTGAGGATGAG TTAAGTTCTTCTACAAGTTCAACTGATAAGTCAGATGGGGATTACGGGGAAGGGAAAGGT CAGACAAATGAAATTAATGCCTTGGTACAATTGATGACTCAGACCCTGAAACTGGATTCT AAAGAGAGCTGTGAAGATGTCCCGGTAGCAAACCCAGTGTCAGAATTCAAACTTCATCGG AAATATCGGGACACACTGATACTTCATGGGAAGGTTGCAGAAGAGGCAGAGGAAATCCAT TTTAAAGAGCTACCTTCAGCTATTATGCCAGGTTCTGAAAAGATCAGGAGACTAGTTGAA GTCTTGAGAACTGATGTAATTCGTGGCCTGGGAGTTCAGCTTTTAGAGCAGGTGTATGAT CTTTTGGAGGAGGAGGATGAATTTGATAGAGAGGTACGTTTGCGGGAGCACATGGGTGAA AAGTATACAACTTACAGTGTGAAAGCTCGCCAGTTGAAATTTTTTGAAGAAAACATGAAT TTTTGA
- Chromosome Location
- 3
- Locus
- 3p21.1
- External Identifiers
Resource Link UniProtKB ID P51957 UniProtKB Entry Name NEK4_HUMAN HGNC ID HGNC:11399 - General References
- Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB, et al.: Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene. 1994 Jul;9(7):1977-88. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
- Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
- Coene KL, Mans DA, Boldt K, Gloeckner CJ, van Reeuwijk J, Bolat E, Roosing S, Letteboer SJ, Peters TA, Cremers FP, Ueffing M, Roepman R: The ciliopathy-associated protein homologs RPGRIP1 and RPGRIP1L are linked to cilium integrity through interaction with Nek4 serine/threonine kinase. Hum Mol Genet. 2011 Sep 15;20(18):3592-605. doi: 10.1093/hmg/ddr280. Epub 2011 Jun 17. [Article]
- Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC: Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol Cell Biol. 2012 Oct;32(19):3963-77. doi: 10.1128/MCB.00436-12. Epub 2012 Jul 30. [Article]
- Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
- Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87. doi: 10.1074/mcp.O113.027870. Epub 2013 Oct 15. [Article]
- Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]