Ephrin type-A receptor 4

Details

Name
Ephrin type-A receptor 4
Synonyms
  • 2.7.10.1
  • EK8
  • EPH-like kinase 8
  • HEK8
  • SEK
  • TYRO1
  • Tyrosine-protein kinase receptor SEK
  • Tyrosine-protein kinase TYRO1
Gene Name
EPHA4
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051754|Ephrin type-A receptor 4
MAGIFYFALFSCLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIM
DEKNTPIRTYQVCNVMEPSQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKE
TFNLYYYESDNDKERFIRENQFVKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK
DVPKMYCGADGEWLVPIGNCLCNAGHEERSGECQACKIGYYKALSTDATCAKCPPHSYSV
WEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDI
SYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTKVSITDLLAHTNYTFEIWAVNGVS
KYNPNPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYE
KDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRII
GDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPF
TYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT
DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTV
IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT
TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG
YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGTESSRPNT
ALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHVNQEDLARIGITAIT
HQNKILSSVQAMRTQMQQMHGRMVPV
Number of residues
986
Molecular Weight
109859.065
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / DH domain binding / ephrin receptor binding / GPI-linked ephrin receptor activity / identical protein binding / kinase activity / PH domain binding / protein kinase activity / protein tyrosine kinase binding / transmembrane-ephrin receptor activity
Processes
adult walking behavior / cell adhesion / cellular response to amyloid-beta / corticospinal tract morphogenesis / ephrin receptor signaling pathway / fasciculation of motor neuron axon / fasciculation of sensory neuron axon / glial cell migration / motor neuron axon guidance / negative regulation of axon regeneration / negative regulation of long-term synaptic potentiation / negative regulation of neuron projection development / negative regulation of proteolysis involved in cellular protein catabolic process / nephric duct morphogenesis / neuron projection fasciculation / neuron projection guidance / peptidyl-tyrosine phosphorylation / positive regulation of amyloid-beta formation / positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process / positive regulation of dendrite morphogenesis / positive regulation of JUN kinase activity / positive regulation of protein tyrosine kinase activity / positive regulation of Rho guanyl-nucleotide exchange factor activity / protein autophosphorylation / protein stabilization / regulation of astrocyte differentiation / regulation of axonogenesis / regulation of dendritic spine morphogenesis / regulation of GTPase activity / regulation of modification of synaptic structure
Components
axon / axon terminus / axonal growth cone / cell junction / cell surface / cytoplasm / dendrite / dendritic shaft / dendritic spine / early endosome membrane / endoplasmic reticulum / filopodium / Golgi apparatus / integral component of plasma membrane / mitochondrial outer membrane / neuromuscular junction / perikaryon / plasma membrane / postsynaptic density / postsynaptic membrane
General Function
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
548-569
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0051755|Ephrin type-A receptor 4 (EPHA4)
ATGGCTGGGATTTTCTATTTCGCCCTATTTTCGTGTCTCTTCGGGATTTGCGACGCTGTC
ACAGGTTCCAGGGTATACCCCGCGAATGAAGTTACCTTATTGGATTCCAGATCTGTTCAG
GGAGAACTTGGGTGGATAGCAAGCCCTCTGGAAGGAGGGTGGGAGGAAGTGAGTATCATG
GATGAAAAAAATACACCAATCCGAACCTACCAAGTGTGCAATGTGATGGAACCCAGCCAG
AATAACTGGCTACGAACTGATTGGATCACCCGAGAAGGGGCTCAGAGGGTGTATATTGAG
ATTAAATTCACCTTGAGGGACTGCAATAGTCTTCCGGGCGTCATGGGGACTTGCAAGGAG
ACGTTTAACCTGTACTACTATGAATCAGACAACGACAAAGAGCGTTTCATCAGAGAGAAC
CAGTTTGTCAAAATTGACACCATTGCTGCTGATGAGAGCTTCACCCAAGTGGACATTGGT
GACAGAATCATGAAGCTGAACACCGAGATCCGGGATGTAGGGCCATTAAGCAAAAAGGGG
TTTTACCTGGCTTTTCAGGATGTGGGGGCCTGCATCGCCCTGGTATCAGTCCGTGTGTTC
TATAAAAAGTGTCCACTCACAGTCCGCAATCTGGCCCAGTTTCCTGACACCATCACAGGG
GCTGATACGTCTTCCCTGGTGGAAGTTCGAGGCTCCTGTGTCAACAACTCAGAAGAGAAA
GATGTGCCAAAAATGTACTGTGGGGCAGATGGTGAATGGCTGGTACCCATTGGCAACTGC
CTATGCAACGCTGGGCATGAGGAGCGGAGCGGAGAATGCCAAGCTTGCAAAATTGGATAT
TACAAGGCTCTCTCCACGGATGCCACCTGTGCCAAGTGCCCACCCCACAGCTACTCTGTC
TGGGAAGGAGCCACCTCGTGCACCTGTGACCGAGGCTTTTTCAGAGCTGACAACGATGCT
GCCTCTATGCCCTGCACCCGTCCACCATCTGCTCCCCTGAACTTGATTTCAAATGTCAAC
GAGACATCTGTGAACTTGGAATGGAGTAGCCCTCAGAATACAGGTGGCCGCCAGGACATT
TCCTATAATGTGGTATGCAAGAAATGTGGAGCTGGTGACCCCAGCAAGTGCCGACCCTGT
GGAAGTGGGGTCCACTACACCCCACAGCAGAATGGCTTGAAGACCACCAAAGTCTCCATC
ACTGACCTCCTAGCTCATACCAATTACACCTTTGAAATCTGGGCTGTGAATGGAGTGTCC
AAATATAACCCTAACCCAGACCAATCAGTTTCTGTCACTGTGACCACCAACCAAGCAGCA
CCATCATCCATTGCTTTGGTCCAGGCTAAAGAAGTCACAAGATACAGTGTGGCACTGGCT
TGGCTGGAACCAGATCGGCCCAATGGGGTAATCCTGGAATATGAAGTCAAGTATTATGAG
AAGGATCAGAATGAGCGAAGCTATCGTATAGTTCGGACAGCTGCCAGGAACACAGATATC
AAAGGCCTGAACCCTCTCACTTCCTATGTTTTCCACGTGCGAGCCAGGACAGCAGCTGGC
TATGGAGACTTCAGTGAGCCCTTGGAGGTTACAACCAACACAGTGCCTTCCCGGATCATT
GGAGATGGGGCTAACTCCACAGTCCTTCTGGTCTCTGTCTCGGGCAGTGTGGTGCTGGTG
GTAATTCTCATTGCAGCTTTTGTCATCAGCCGGAGACGGAGTAAATACAGTAAAGCCAAA
CAAGAAGCGGATGAAGAGAAACATTTGAATCAAGGTGTAAGAACATATGTGGACCCCTTT
ACGTACGAAGATCCCAACCAAGCAGTGCGAGAGTTTGCCAAAGAAATTGACGCATCCTGC
ATTAAGATTGAAAAAGTTATAGGAGTTGGTGAATTTGGTGAGGTATGCAGTGGGCGTCTC
AAAGTGCCTGGCAAGAGAGAGATCTGTGTGGCTATCAAGACTCTGAAAGCTGGTTATACA
GACAAACAGAGGAGAGACTTCCTGAGTGAGGCCAGCATCATGGGACAGTTTGACCATCCG
AACATCATTCACTTGGAAGGCGTGGTCACTAAATGTAAACCAGTAATGATCATAACAGAG
TACATGGAGAATGGCTCCTTGGATGCATTCCTCAGGAAAAATGATGGCAGATTTACAGTC
ATTCAGCTGGTGGGCATGCTTCGTGGCATTGGGTCTGGGATGAAGTATTTATCTGATATG
AGCTATGTGCATCGTGATCTGGCCGCACGGAACATCCTGGTGAACAGCAACTTGGTCTGC
AAAGTGTCTGATTTTGGCATGTCCCGAGTGCTTGAGGATGATCCGGAAGCAGCTTACACC
ACCAGGGGTGGCAAGATTCCTATCCGGTGGACTGCGCCAGAAGCAATTGCCTATCGTAAA
TTCACATCAGCAAGTGATGTATGGAGCTATGGAATCGTTATGTGGGAAGTGATGTCGTAC
GGGGAGAGGCCCTATTGGGATATGTCCAATCAAGATGTGATTAAAGCCATTGAGGAAGGC
TATCGGTTACCCCCTCCAATGGACTGCCCCATTGCGCTCCACCAGCTGATGCTAGACTGC
TGGCAGAAGGAGAGGAGCGACAGGCCTAAATTTGGGCAGATTGTCAACATGTTGGACAAA
CTCATCCGCAACCCCAACAGCTTGAAGAGGACAGGGACGGAGAGCTCCAGACCTAACACT
GCCTTGTTGGATCCAAGCTCCCCTGAATTCTCTGCTGTGGTATCAGTGGGCGATTGGCTC
CAGGCCATTAAAATGGACCGGTATAAGGATAACTTCACAGCTGCTGGTTATACCACACTA
GAGGCTGTGGTGCACGTGAACCAGGAGGACCTGGCAAGAATTGGTATCACAGCCATCACG
CACCAGAATAAGATTTTGAGCAGTGTCCAGGCAATGCGAACCCAAATGCAGCAGATGCAC
GGCAGAATGGTTCCCGTCTGA
Chromosome Location
2
Locus
2q36.1
External Identifiers
ResourceLink
UniProtKB IDP54764
UniProtKB Entry NameEPHA4_HUMAN
HGNC IDHGNC:3388
General References
  1. Fox GM, Holst PL, Chute HT, Lindberg RA, Janssen AM, Basu R, Welcher AA: cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. Oncogene. 1995 Mar 2;10(5):897-905. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails