Protoporphyrinogen oxidase
Details
- Name
- Protoporphyrinogen oxidase
- Synonyms
- 1.3.3.4
- PPO
- Gene Name
- hemY
- Organism
- Myxococcus xanthus
- Amino acid sequence
>lcl|BSEQ0012653|Protoporphyrinogen oxidase MHHMPRTTGMNVAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQ GPNSFLDREPATRALAAALNLEGRIRAADPAAKRRYVYTRGRLRSVPASPPAFLASDILP LGARLRVAGELFSRRAPEGVDESLAAFGRRHLGHRATQVLLDAVQTGIYAGDVEQLSVAA TFPMLVKMEREHRSLILGAIRAQKAQRQAALPAGTAPKLSGALSTFDGGLQVLIDALAAS LGDAAHVGARVEGLAREDGGWRLIIEEHGRRAELSVAQVVLAAPAHATAKLLRPLDDALA ALVAGIAYAPIAVVHLGFDAGTLPAPDGFGFLVPAEEQRRMLGAIHASTTFPFRAEGGRV LYSCMVGGARQPGLVEQDEDALAALAREELKALAGVTARPSFTRVFRWPLGIPQYNLGHL ERVAAIDAALQRLPGLHLIGNAYKGVGLNDCIRNAAQLADALVAGNTSHAP
- Number of residues
- 471
- Molecular Weight
- 49387.12
- Theoretical pI
- 9.76
- GO Classification
- Functionsoxygen-dependent protoporphyrinogen oxidase activityProcessesprotoporphyrinogen IX biosynthetic processComponentscytoplasm / membrane
- General Function
- Oxygen-dependent protoporphyrinogen oxidase activity
- Specific Function
- Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
- Pfam Domain Function
- Amino_oxidase (PF01593)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0007299|690 bp ATGCGCTACGTCATCACCGGAGCGAGCAGGGGGATTGGTTTCGAATTCGTCCAGCAGCTC CTGCTGCGGGGCGATACCGTCGAAGCCGGGGTCAGGTCGCCAGAGGGAGCACGGCGGCTG GAGCCGTTGAAACAGAAGGCGGGCAACCGCCTGCGCATCCATGCGCTGGACGTGGGAGAC GACGACAGCGTGCGCGCGTTCGCCACCAACGTGTGTACCGGTCCCGTGGACGTGCTCATC AACAACGCCGGTGTCTCCGGCTTGTGGTGCGCGTTGGGTGACGTGGACTACGCGGACATG GCGCGCACGTTCACCATCAACGCCCTGGGGCCGCTGCGTGTCACCAGCGCGATGCTGCCG GGCTTGCGGCAAGGCGCCTTGCGGCGGGTGGCGCACGTCACCTCGCGGATGGGCTCGTTG GCGGCGAACACCGACGGGGGGGCCTATGCGTACCGCATGTCGAAGGCCGCGCTGAACATG GCCGTGCGCTCCATGTCCACGGACCTGCGCCCGGAGGGCTTCGTCACCGTGCTGCTCCAC CCCGGTTGGGTGCAGACGGACATGGGCGGCCCGGACGCCACGCTGCCGGCGCCGGATTCG GTGCGCGGCATGCTGCGGGTCATCGACGGGCTGAACCCGGAGCACAGCGGCCGGTTCTTC GACTACCAGGGGACCGAAGTGCCCTGGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P56601 UniProtKB Entry Name PPOX_MYXXA GenBank Protein ID 20800464 GenBank Gene ID L27429 - General References
- Li S, Lee BU, Shimkets LJ: csgA expression entrains Myxococcus xanthus development. Genes Dev. 1992 Mar;6(3):401-10. [Article]
- Dailey HA, Dailey TA: Protoporphyrinogen oxidase of Myxococcus xanthus. Expression, purification, and characterization of the cloned enzyme. J Biol Chem. 1996 Apr 12;271(15):8714-8. [Article]
- Corradi HR, Corrigall AV, Boix E, Mohan CG, Sturrock ED, Meissner PN, Acharya KR: Crystal structure of protoporphyrinogen oxidase from Myxococcus xanthus and its complex with the inhibitor acifluorfen. J Biol Chem. 2006 Dec 15;281(50):38625-33. Epub 2006 Oct 17. [Article]