Actin-related protein 2

Details

Name
Actin-related protein 2
Synonyms
  • Actin-like protein 2
  • ARP2
Gene Name
ACTR2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0008081|Actin-related protein 2
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDE
ASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNR
EKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTR
RLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVL
VESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKH
IVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAV
LADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
Number of residues
394
Molecular Weight
44760.475
Theoretical pI
6.72
GO Classification
Functions
ATP binding / structural constituent of cytoskeleton
Processes
Arp2/3 complex-mediated actin nucleation / asymmetric cell division / axon guidance / cilium assembly / cytoplasmic transport / ephrin receptor signaling pathway / establishment or maintenance of cell polarity / Fc-gamma receptor signaling pathway involved in phagocytosis / innate immune response / meiotic chromosome movement towards spindle pole / meiotic cytokinesis / movement of cell or subcellular component / small GTPase mediated signal transduction / spindle localization
Components
actin cap / actin cytoskeleton / Arp2/3 protein complex / cell projection / cytoplasm / cytosol / extracellular exosome / focal adhesion / membrane
General Function
Structural constituent of cytoskeleton
Specific Function
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0021381|Actin-related protein 2 (ACTR2)
ATGGACAGCCAGGGCAGGAAGGTGGTGGTGTGCGACAACGGCACCGGGTTTGTGAAGTGT
GGATATGCAGGCTCTAACTTTCCAGAACACATCTTCCCAGCTTTGGTTGGAAGACCTATT
ATCAGATCAACCACCAAAGTGGGAAACATTGAAATCAAGAATAACAAAAAGATGGATCTT
ATGGTTGGTGATGAGGCAAGTGAATTACGATCAATGTTAGAAGTTAACTACCCTATGGAA
AATGGCATAGTACGAAATTGGGATGACATGAAACACCTGTGGGACTACACATTTGGACCA
GAGAAACTTAATATAGATACCAGAAATTGTAAAATCTTACTCACAGAACCTCCTATGAAC
CCAACCAAAAACAGAGAGAAGATTGTAGAGGTAATGTTTGAAACTTACCAGTTTTCCGGT
GTATATGTAGCCATCCAGGCAGTTCTGACTTTGTACGCTCAAGGTTTATTGACTGGTGTA
GTGGTAGACTCTGGAGATGGTGTGACTCACATTTGCCCAGTATATGAAGGCTTTTCTCTC
CCTCATCTTACCAGGAGACTGGATATTGCTGGGAGGGATATAACTAGATATCTTATCAAG
CTACTTCTGTTGCGAGGATACGCCTTCAACCACTCTGCTGATTTTGAAACGGTTCGCATG
ATTAAAGAAAAACTGTGTTACGTGGGATATAATATTGAGCAAGAGCAGAAACTGGCCTTA
GAAACCACAGTATTAGTTGAATCTTATACACTCCCAGATGGACGTATCATCAAAGTTGGG
GGAGAGAGATTTGAAGCACCAGAAGCTTTATTTCAGCCTCACTTGATCAATGTTGAAGGA
GTTGGTGTTGCTGAATTGCTTTTTAACACAATTCAGGCAGCTGACATTGATACCAGATCT
GAATTCTACAAACACATTGTGCTTTCTGGAGGGTCTACTATGTATCCTGGCCTGCCATCA
CGGTTGGAACGAGAACTTAAACAGCTTTACTTAGAACGAGTTTTGAAGGGTGATGTGGAA
AAACTTTCTAAATTTAAGATCCGCATTGAAGACCCACCCCGCAGAAAGCACATGGTATTC
CTGGGTGGTGCAGTTCTAGCGGATATCATGAAAGACAAAGACAACTTTTGGATGACCCGA
CAAGAGTACCAAGAAAAGGGTGTCCGTGTGCTAGAGAAACTTGGTGTGACTGTTCGATAA
Chromosome Location
2
Locus
2p14
External Identifiers
ResourceLink
UniProtKB IDP61160
UniProtKB Entry NameARP2_HUMAN
GenBank Protein ID2282030
GenBank Gene IDAF006082
HGNC IDHGNC:169
General References
  1. Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ: The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J Cell Biol. 1997 Jul 28;138(2):375-84. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08235N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamideexperimentalunknownDetails
DB08236(2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-oneexperimentalunknownDetails