Calcineurin subunit B type 1
Details
- Name
- Calcineurin subunit B type 1
- Synonyms
- CNA2
- CNB
- Protein phosphatase 2B regulatory subunit 1
- Protein phosphatase 3 regulatory subunit B alpha isoform 1
- Gene Name
- PPP3R1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010107|Calcineurin subunit B type 1 MGNEASYPLEMCSHFDADEIKRLGKRFKKLDLDNSGSLSVEEFMSLPELQQNPLVQRVID IFDTDGNGEVDFKEFIEGVSQFSVKGDKEQKLRFAFRIYDMDKDGYISNGELFQVLKMMV GNNLKDTQLQQIVDKTIINADKDGDGRISFEEFCAVVGGLDIHKKMVVDV
- Number of residues
- 170
- Molecular Weight
- 19299.785
- Theoretical pI
- 4.4
- GO Classification
- Functionscalcium ion binding / calcium-dependent protein serine/threonine phosphatase activity / calmodulin binding / protein domain specific bindingProcessesapoptotic process / calcineurin-NFAT signaling cascade / Fc-epsilon receptor signaling pathway / innate immune response / intrinsic apoptotic signaling pathway / positive regulation of NFAT protein import into nucleus / positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway / positive regulation of transcription from RNA polymerase II promoter / programmed cell death / protein dephosphorylation / stimulatory C-type lectin receptor signaling pathwayComponentscalcineurin complex / cytosol / nucleoplasm / sarcolemma
- General Function
- Protein domain specific binding
- Specific Function
- Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
- Pfam Domain Function
- EF-hand_7 (PF13499)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010108|Calcineurin subunit B type 1 (PPP3R1) ATGGGAAATGAGGCAAGTTATCCTTTGGAAATGTGCTCACACTTTGATGCGGATGAAATT AAAAGGCTAGGAAAGAGATTTAAGAAGCTTGATTTGGACAATTCTGGTTCTTTGAGTGTG GAAGAGTTCATGTCTCTGCCTGAGTTACAACAGAATCCTTTAGTACAGCGAGTAATAGAT ATATTCGACACAGATGGGAATGGAGAAGTAGACTTTAAAGAATTCATTGAGGGCGTCTCT CAGTTCAGTGTCAAAGGAGATAAGGAGCAGAAATTGAGGTTTGCTTTCCGTATCTATGAC ATGGATAAAGATGGCTATATTTCCAATGGGGAACTCTTCCAGGTATTGAAGATGATGGTG GGGAACAATCTGAAAGATACACAGTTACAGCAAATTGTAGACAAAACCATAATAAATGCA GATAAGGATGGAGATGGAAGAATATCCTTTGAAGAATTCTGTGCTGTTGTAGGTGGCCTA GATATCCACAAAAAGATGGTGGTAGATGTGTGA
- Chromosome Location
- 2
- Locus
- 2p15
- External Identifiers
Resource Link UniProtKB ID P63098 UniProtKB Entry Name CANB1_HUMAN GenBank Protein ID 180705 GenBank Gene ID M30773 GenAtlas ID PPP3R1 HGNC ID HGNC:9317 - General References
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