Casein kinase II subunit beta

Details

Name
Casein kinase II subunit beta
Synonyms
  • CK II beta
  • CK2N
  • G5A
  • Phosvitin
  • Protein G5a
Gene Name
CSNK2B
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009189|Casein kinase II subunit beta
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDE
ELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPML
PIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPA
NQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
Number of residues
215
Molecular Weight
24942.25
Theoretical pI
Not Available
GO Classification
Functions
chromatin binding / identical protein binding / metal ion binding / protein domain specific binding / protein kinase regulator activity / receptor binding / transcription factor binding
Processes
adiponectin-activated signaling pathway / axon guidance / cellular protein complex assembly / endothelial tube morphogenesis / mitotic cell cycle / negative regulation of blood vessel endothelial cell migration / negative regulation of cell proliferation / positive regulation of activin receptor signaling pathway / positive regulation of pathway-restricted SMAD protein phosphorylation / protein phosphorylation / regulation of DNA binding / regulation of protein kinase activity / signal transduction / Wnt signaling pathway
Components
cytoplasm / cytosol / extracellular exosome / nucleus / protein kinase CK2 complex
General Function
Transcription factor binding
Specific Function
Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017714|Casein kinase II subunit beta (CSNK2B)
ATGAGCAGCTCAGAGGAGGTGTCCTGGATTTCCTGGTTCTGTGGGCTCCGTGGCAATGAA
TTCTTCTGTGAAGTGGATGAAGACTACATCCAGGACAAATTTAATCTTACTGGACTCAAT
GAGCAGGTCCCTCACTATCGACAAGCTCTAGACATGATCTTGGACCTGGAGCCTGATGAA
GAACTGGAAGACAACCCCAACCAGAGTGACCTGATTGAGCAGGCAGCCGAGATGCTTTAT
GGATTGATCCACGCCCGCTACATCCTTACCAACCGTGGCATCGCCCAGATGTTGGAAAAG
TACCAGCAAGGAGACTTTGGTTACTGTCCTCGTGTGTACTGTGAGAACCAGCCAATGCTT
CCCATTGACATCCCAGGTGAAGCCATGGTGAAGCTCTACTGCCCCAAGTGCATGGATGTG
TACACACCCAAGTCATCAAGACACCATCACACGGATGGCGCCTACTTCGGCACTGGTTTC
CCTCACATGCTCTTCATGGTGCATCCCGAGTACCGGCCCAAGAGACCTGCCAACCAGTTT
GTGCCCAGGCTCTACGGTTTCAAGATCCATCCGATGGCCTACCAGCTGCAGCTCCAAGCC
GCCAGCAACTTCAAGAGCCCAGTCAAGACGATTCGCTGA
Chromosome Location
6
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP67870
UniProtKB Entry NameCSK2B_HUMAN
HGNC IDHGNC:2460
General References
  1. Jakobi R, Voss H, Pyerin W: Human phosvitin/casein kinase type II. Molecular cloning and sequencing of full-length cDNA encoding subunit beta. Eur J Biochem. 1989 Jul 15;183(1):227-33. [Article]
  2. Teitz T, Eli D, Penner M, Bakhanashvili M, Naiman T, Timme TL, Wood CM, Moses RE, Canaani D: Expression of the cDNA for the beta subunit of human casein kinase II confers partial UV resistance on xeroderma pigmentosum cells. Mutat Res. 1990 Jul;236(1):85-97. [Article]
  3. Heller-Harrison RA, Meisner H, Czech MP: Cloning and characterization of a cDNA encoding the beta subunit of human casein kinase II. Biochemistry. 1989 Nov 14;28(23):9053-8. [Article]
  4. Voss H, Wirkner U, Jakobi R, Hewitt NA, Schwager C, Zimmermann J, Ansorge W, Pyerin W: Structure of the gene encoding human casein kinase II subunit beta. J Biol Chem. 1991 Jul 25;266(21):13706-11. [Article]
  5. Singh LS, Kalafatis M: Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line. Biochemistry. 2002 Jul 16;41(28):8935-40. [Article]
  6. Xie T, Rowen L, Aguado B, Ahearn ME, Madan A, Qin S, Campbell RD, Hood L: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse. Genome Res. 2003 Dec;13(12):2621-36. [Article]
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  10. Ackerman P, Glover CV, Osheroff N: Stimulation of casein kinase II by epidermal growth factor: relationship between the physiological activity of the kinase and the phosphorylation state of its beta subunit. Proc Natl Acad Sci U S A. 1990 Jan;87(2):821-5. [Article]
  11. Ritter M, Buechler C, Kapinsky M, Schmitz G: Interaction of CD163 with the regulatory subunit of casein kinase II (CKII) and dependence of CD163 signaling on CKII and protein kinase C. Eur J Immunol. 2001 Apr;31(4):999-1009. [Article]
  12. Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H: A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol Cell. 2001 Feb;7(2):283-92. [Article]
  13. Skjerpen CS, Wesche J, Olsnes S: Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor. J Biol Chem. 2002 Jun 28;277(26):23864-71. Epub 2002 Apr 18. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00171ATPinvestigational, nutraceuticalunknownDetails
DB04216Quercetinexperimental, investigationalunknownDetails