Apocarotenoid-15,15'-oxygenase

Details

Name
Apocarotenoid-15,15'-oxygenase
Synonyms
  • 8'-apo-beta-carotenal 15,15'-oxygenase
  • ACO
  • Diox1
Gene Name
Not Available
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Amino acid sequence
>lcl|BSEQ0019326|Apocarotenoid-15,15'-oxygenase
MVTSPPTSSPSQRSYSPQDWLRGYQSQPQEWDYWVEDVEGSIPPDLQGTLYRNGPGLLEI
GDRPLKHPFDGDGMVTAFKFPGDGRVHFQSKFVRTQGYVEEQKAGKMIYRGVFGSQPAGG
WLKTIFDLRLKNIANTNITYWGDRLLALWEGGQPHRLEPSNLATIGLDDLGGILAEGQPL
SAHPRIDPASTFDGGQPCYVTFSIKSSLSSTLTLLELDPQGKLLRQKTETFPGFAFIHDF
AITPHYAIFLQNNVTLNGLPYLFGLRGAGECVQFHPDKPAQIILVPRDGGEIKRIPVQAG
FVFHHANAFEENGKIILDSICYNSLPQVDTDGDFRSTNFDNLDPGQLWRFTIDPAAATVE
KQLMVSRCCEFPVVHPQQVGRPYRYVYMGAAHHSTGNAPLQAILKVDLESGTETLRSFAP
HGFAGEPIFVPRPGGVAEDDGWLLCLIYKADLHRSELVILDAQDITAPAIATLKLKHHIP
YPLHGSWAQT
Number of residues
490
Molecular Weight
54286.065
Theoretical pI
6.16
GO Classification
Functions
dioxygenase activity / metal ion binding
General Function
Metal ion binding
Specific Function
Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta-carotene or lycopene.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0005326|1473 bp
TCAAGTCTGGGCCCAGGAACCGTGCAGGGGATAGGGAATGTGATGCTTTAACTTCAAAGT
GGCGATCGCCGGAGCAGTAATGTCCTGAGCATCAAGAATCACTAGTTCGGAACGGTGCAA
ATCAGCTTTATAAATCAAGCAGAGCAACCAACCATCATCTTCAGCCACGCCACCGGGTCG
GGGCACAAAAATAGGTTCCCCGGCAAAACCATGGGGGGCAAAGGAACGTAGAGTTTCAGT
GCCGGACTCTAGATCTACTTTGAGAATGGCCTGAAGGGGAGCATTGCCTGTGCTATGGTG
TGCGGCTCCCATGTAAACATAGCGATATGGACGGCCAACCTGCTGGGGATGGACAACGGG
AAACTCGCAACAACGACTAACCATTAACTGTTTTTCCACCGTGGCTGCTGCGGGATCAAT
GGTGAAACGCCATAACTGTCCGGGATCTAAATTATCGAAATTCGTACTACGAAAATCCCC
ATCGGTGTCTACCTGGGGCAGGGAATTGTAACAAATGGAATCGAGGATTATTTTGCCATT
TTCCTCAAAAGCGTTGGCATGGTGAAAAACAAAGCCTGCCTGTACCGGAATTCTTTTTAT
TTCTCCACCGTCCCTAGGAACGAGAATAATTTGAGCAGGTTTATCGGGATGAAATTGCAC
ACATTCCCCTGCTCCTCGCAAACCGAAAAGGTAGGGTAACCCGTTGAGAGTAACGTTATT
TTGCAGAAAAATGGCGTAATGGGGCGTGATCGCAAAATCATGAATAAAAGCAAAACCAGG
AAAAGTTTCAGTTTTTTGCCGCAACAATTTACCCTGGGGGTCTAGCTCTAACAGGGTGAG
GGTACTGCTCAAGCTGGATTTAATTGAAAAGGTCACATAGCAGGGTTGGCCCCCATCAAA
AGTTGAAGCCGGATCAATGCGGGGATGGGCCGACAGGGGTTGCCCTTCCGCAAGAATGCC
GCCCAAATCATCCAACCCAATGGTTGCTAAGTTTGATGGTTCCAAGCGATGGGGTTGTCC
CCCTTCCCATAGGGCCAAGAGGCGATCGCCCCAGTAGGTAATGTTGGTGTTGGCAATGTT
TTTTAGCCGTAAGTCAAAGATAGTTTTGAGCCAGCCCCCCGCCGGTTGGGAACCAAAGAC
GCCCCGATAGATCATTTTTCCCGCTTTTTGCTCTTCCACGTAACCCTGGGTGCGGACAAA
TTTGCTCTGGAAATGTACTCGACCGTCCCCAGGAAATTTAAAGGCTGTCACCATGCCGTC
CCCGTCAAAGGGATGCTTCAAAGGGCGATCGCCAATTTCCAATAATCCAGGGCCGTTGCG
ATAGAGCGTTCCCTGGAGGTCTGGGGGTATGCTCCCTTCCACGTCTTCGACCCAATAATC
CCACTCCTGGGGCTGGGACTGGTAACCTCTCAGCCAATCCTGCGGACTGTAGGAGCGCTG
CGATGGGGAACTGGTTGGGGGGGAAGTGACCAT
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP74334
UniProtKB Entry NameACOX_SYNY3
GenBank Gene IDBA000022
General References
  1. Kaneko T, Sato S, Kotani H, Tanaka A, Asamizu E, Nakamura Y, Miyajima N, Hirosawa M, Sugiura M, Sasamoto S, Kimura T, Hosouchi T, Matsuno A, Muraki A, Nakazaki N, Naruo K, Okumura S, Shimpo S, Takeuchi C, Wada T, Watanabe A, Yamada M, Yasuda M, Tabata S: Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions. DNA Res. 1996 Jun 30;3(3):109-36. [Article]
  2. Ruch S, Beyer P, Ernst H, Al-Babili S: Retinal biosynthesis in Eubacteria: in vitro characterization of a novel carotenoid oxygenase from Synechocystis sp. PCC 6803. Mol Microbiol. 2005 Feb;55(4):1015-24. [Article]
  3. Kloer DP, Ruch S, Al-Babili S, Beyer P, Schulz GE: The structure of a retinal-forming carotenoid oxygenase. Science. 2005 Apr 8;308(5719):267-9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02253(1r)-4-[(1e,3e,5e,7z,9e,11z,13e,15e)-17-Hydroxy-3,7,12,16-Tetramethylheptadeca-1,3,5,7,9,11,13,15-Octaen-1-Yl]-3,5,5-Trimethylcyclohex-3-En-1-OlexperimentalunknownDetails
DB04233(Hydroxyethyloxy)Tri(Ethyloxy)OctaneexperimentalunknownDetails