Nucleobindin-2

Details

Name
Nucleobindin-2
Synonyms
  • DNA-binding protein NEFA
  • Gastric cancer antigen Zg4
  • NEFA
  • Prepronesfatin
Gene Name
NUCB2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049496|Nucleobindin-2
MRWRTILLQYCFLLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQ
VIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKA
KLDSLQDIGMDHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKY
EMMKEHERREYLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLD
PNDFDPKTFFKLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREH
VMSEVDTNKDRLVTLEEFLKATEKKEFLEPDSWETLDQQQFFTEEELKEYENIIALQENE
LKKKADELQKQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQGIPPSGPAGELKFEPHI
Number of residues
420
Molecular Weight
50195.385
Theoretical pI
Not Available
GO Classification
Functions
calcium ion binding / DNA binding
Components
cytosol / endoplasmic reticulum / endoplasmic reticulum-Golgi intermediate compartment / extracellular exosome / extracellular space / Golgi apparatus / nuclear envelope / plasma membrane
General Function
Calcium-binding protein. May have a role in calcium homeostasis.
Specific Function
Calcium ion binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Golgi apparatus
Gene sequence
>lcl|BSEQ0049497|Nucleobindin-2 (NUCB2)
ATGAGGTGGAGGACCATCCTGCTACAGTATTGCTTTCTCTTGATTACATGTTTACTTACT
GCTCTTGAAGCTGTGCCTATTGACATAGACAAGACAAAAGTACAAAATATTCACCCTGTG
GAAAGTGCGAAGATAGAACCACCAGATACTGGACTTTATTATGATGAATATCTCAAGCAA
GTGATTGATGTGCTGGAAACAGATAAACACTTCAGAGAAAAGCTCCAGAAAGCAGACATA
GAGGAAATAAAGAGTGGGAGGCTAAGCAAAGAACTGGATTTAGTAAGTCACCATGTGAGG
ACAAAACTTGATGAACTGAAAAGGCAAGAAGTAGGAAGGTTAAGAATGTTAATTAAAGCT
AAGTTGGATTCCCTTCAAGATATAGGCATGGACCACCAAGCTCTTCTAAAACAATTTGAT
CACCTAAACCACCTGAATCCTGACAAGTTTGAATCCACAGATTTAGATATGCTAATCAAA
GCGGCAACAAGTGATCTGGAACACTATGACAAGACTCGTCATGAAGAATTTAAAAAATAT
GAAATGATGAAGGAACATGAAAGGAGAGAATATTTAAAAACATTGAATGAAGAAAAGAGA
AAAGAAGAAGAGTCTAAATTTGAAGAAATGAAGAAAAAGCATGAAAATCACCCTAAAGTT
AATCACCCAGGAAGCAAAGATCAACTAAAAGAGGTATGGGAAGAGACTGATGGATTGGAT
CCTAATGACTTTGACCCCAAGACATTTTTCAAATTACATGATGTCAATAGTGATGGATTC
CTGGATGAACAAGAATTAGAAGCCCTATTTACTAAAGAGTTGGAGAAAGTATATGACCCT
AAAAATGAAGAGGATGATATGGTAGAAATGGAAGAAGAAAGGCTTAGAATGAGGGAACAT
GTAATGAATGAGGTTGATACTAACAAAGACAGATTGGTGACTCTGGAGGAGTTTTTGAAA
GCCACAGAAAAAAAAGAATTCTTGGAGCCAGATAGCTGGGAGACATTAGATCAGCAACAG
TTCTTCACAGAGGAAGAACTAAAAGAATATGAAAATATTATTGCTTTACAAGAAAATGAA
CTTAAGAAGAAGGCAGATGAGCTTCAGAAACAAAAAGAAGAGCTACAACGTCAGCATGAT
CAACTGGAGGCTCAGAAGCTGGAATATCATCAGGTCATACAGCAGATGGAACAAAAAAAA
TTACAACAAGGAATTCCTCCATCAGGGCCAGCTGGAGAATTGAAGTTTGAGCCACACATT
TAA
Chromosome Location
11
Locus
11p15.1
External Identifiers
ResourceLink
UniProtKB IDP80303
UniProtKB Entry NameNUCB2_HUMAN
HGNC IDHGNC:8044
General References
  1. Barnikol-Watanabe S, Gross NA, Gotz H, Henkel T, Karabinos A, Kratzin H, Barnikol HU, Hilschmann N: Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein. Biol Chem Hoppe Seyler. 1994 Aug;375(8):497-512. [Article]
  2. DeAngelis MM, Doucet JP, Drury S, Sherry ST, Robichaux MB, Den Z, Pelias MZ, Ditta GM, Keats BJ, Deininger PL, Batzer MA: Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene. Biochim Biophys Acta. 1998 Jul 1;1407(1):84-91. [Article]
  3. Line A, Stengrevics A, Slucka Z, Li G, Jankevics E, Rees RC: Serological identification and expression analysis of gastric cancer-associated genes. Br J Cancer. 2002 Jun 5;86(11):1824-30. [Article]
  4. Yamada M, Horiguchi K, Umezawa R, Hashimoto K, Satoh T, Ozawa A, Shibusawa N, Monden T, Okada S, Shimizu H, Mori M: Troglitazone, a ligand of peroxisome proliferator-activated receptor-{gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene. Endocrinology. 2010 Jun;151(6):2494-503. doi: 10.1210/en.2009-1169. Epub 2010 Apr 28. [Article]
  5. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  6. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
  7. Nesselhut J, Jurgan U, Onken E, Gotz H, Barnikol HU, Hirschfeld G, Barnikol-Watanabe S, Hilschmann N: Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region. FEBS Lett. 2001 Dec 14;509(3):469-75. [Article]
  8. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
  9. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  10. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  11. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  12. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11093Calcium citrateapproved, investigationalunknownligandDetails
DB11348Calcium PhosphateapprovedunknownligandDetails
DB14481Calcium phosphate dihydrateapprovedunknownDetails