Aromatic-amino-acid aminotransferase

Details

Name
Aromatic-amino-acid aminotransferase
Synonyms
  • 2.6.1.57
  • ARAT
Gene Name
tyrB
Organism
Paracoccus denitrificans
Amino acid sequence
>lcl|BSEQ0010973|Aromatic-amino-acid aminotransferase
MLGNLKPQAPDKILALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQRMLETE
TTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALRQALELARMANPDLRV
FVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVDFEGMKADLAAAKKGDMVLLHGCCHN
PTGANLTLDQWAEIASILEKTGALPLIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAAS
CSKNFGIYRERTGCLLALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPEL
RADWMAELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQVKRIKE
EFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV
Number of residues
394
Molecular Weight
42731.635
Theoretical pI
5.49
GO Classification
Functions
aromatic-amino-acid / L-phenylalanine / pyridoxal phosphate binding
Processes
aromatic amino acid family biosynthetic process
Components
cytoplasm
General Function
Pyridoxal phosphate binding
Specific Function
Shows activities toward both dicarboxylic and aromatic substrates.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0002756|1185 bp
ATGCTGGGCAATCTGAAACCGCAGGCCCCCGACAAGATCCTGGCCCTGATGGGCGAATTC
AGGGCCGATCCCCGCCAGGGCAAGATCGACCTGGGCGTGGGGGTCTACAAGGATGCCACC
GGCCACACCCCGATCATGCGGGCCGTCCACGCCGCCGAGCAGCGCATGCTGGAAACCGAG
ACCACCAAGACCTATGCCGGCCTCTCGGGCGAGCCCGAGTTCCAAAAGGCCATGGGCGAG
CTGATCCTGGGCGACGGACTGAAATCCGAGACCACCGCGACGCTGGCGACGGTCGGCGGC
ACCGGCGCCCTCCGGCAGGCGCTGGAACTGGCGCGCATGGCGAACCCGGACCTGCGGGTC
TTCGTCAGCGATCCGACCTGGCCGAACCATGTCTCGATCATGAATTTCATGGGCCTGCCG
GTGCAGACCTATCGCTATTTCGATGCCGAGACCCGCGGCGTCGATTTCGAGGGCATGAAG
GCCGACCTCGCCGCCGCGAAAAAGGGCGACATGGTGCTGCTGCACGGCTGCTGCCACAAC
CCGACCGGCGCCAACCTGACGCTGGATCAATGGGCCGAGATCGCCTCGATCCTGGAAAAG
ACCGGCGCGCTGCCGCTGATCGACCTGGCCTATCAGGGCTTCGGCGACGGGCTGGAAGAG
GACGCGGCCGGCACCCGGCTGATCGCCTCGCGCATCCCCGAGGTGCTGATCGCGGCCTCG
TGCAGCAAGAACTTCGGCATCTACCGCGAACGCACCGGCTGCCTGCTGGCGCTTTGCGCC
GATGCGGCGACCAGGGAGCTGGCGCAGGGCGCCATGGCCTTCCTGAACCGCCAGACCTAT
TCCTTCCCGCCCTTCCACGGCGCCAAGATCGTCTCGACCGTGCTGACCACGCCCGAACTG
CGCGCCGACTGGATGGCCGAGCTGGAAGCGGTGCGCAGCGGCATGCTGCGCCTGCGCGAG
CAATTGGCGGGCGAGTTGCGCGATCTCAGCGGTTCGGACCGTTTCGGCTTCGTGGCCGAG
CATCGCGGCATGTTCTCGCGCCTGGGCGCCACGCCCGAACAGGTCAAGCGCATCAAGGAA
GAGTTCGGCATCTACATGGTGGGCGATTCGCGCATCAACATCGCCGGGCTGAACGACAAC
ACCATCCCGATCCTGGCCCGCGCTATCATCGAGGTGGGGGTCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP95468
UniProtKB Entry NameTYRB_PARDE
GenBank Protein ID1806263
GenBank Gene IDY08272
General References
  1. Oue S, Okamoto A, Nakai Y, Nakahira M, Shibatani T, Hayashi H, Kagamiyama H: Paracoccus denitrificans aromatic amino acid aminotransferase: a model enzyme for the study of dual substrate recognition mechanism. J Biochem. 1997 Jan;121(1):161-71. [Article]
  2. Okamoto A, Nakai Y, Hayashi H, Hirotsu K, Kagamiyama H: Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network. J Mol Biol. 1998 Jul 17;280(3):443-61. [Article]
  3. Okamoto A, Ishii S, Hirotsu K, Kagamiyama H: The active site of Paracoccus denitrificans aromatic amino acid aminotransferase has contrary properties: flexibility and rigidity. Biochemistry. 1999 Jan 26;38(4):1176-84. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06819Phenylbutyric acidapproved, investigationalunknownDetails
DB020243-phenylpropionic acidexperimentalunknownDetails
DB02242Cyclohexanepropanoic acidexperimentalunknownDetails
DB024344-(2-Thienyl)Butyric AcidexperimentalunknownDetails
DB027403-Indolebutyric AcidexperimentalunknownDetails
DB02758Indolepropionic acidexperimentalunknownDetails
DB032104-Aminohydrocinnamic AcidexperimentalunknownDetails
DB034003-(P-Tolyl)Propionic AcidexperimentalunknownDetails
DB040515-phenylpentanoic acidexperimentalunknownDetails
DB042083-(3,4-dimethoxyphenyl)propanoic acidexperimentalunknownDetails
DB04299Maleic acidexperimentalunknownDetails