2-isopropylmalate synthase
Details
- Name
- 2-isopropylmalate synthase
- Synonyms
- 2.3.3.13
- Alpha-IPM synthase
- Alpha-isopropylmalate synthase
- Gene Name
- leuA
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051241|2-isopropylmalate synthase MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
- Number of residues
- 644
- Molecular Weight
- 70112.945
- Theoretical pI
- Not Available
- GO Classification
- Functions2-isopropylmalate synthase activity / magnesium ion binding / manganese ion binding / potassium ion binding / zinc ion bindingProcessesgrowth / leucine biosynthetic processComponentsextracellular region / plasma membrane
- General Function
- Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
- Specific Function
- 2-isopropylmalate synthase activity
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051242|2-isopropylmalate synthase (leuA) GTGACAACTTCTGAATCGCCCGACGCCTATACCGAGTCGTTTGGGGCCCACACCATCGTG AAACCCGCCGGCCCACCTCGCGTCGGTCAGCCCTCGTGGAATCCGCAGCGAGCCTCGTCG ATGCCGGTCAACCGCTACCGGCCGTTCGCCGAGGAGGTCGAGCCCATCCGGCTGAGAAAC CGCACGTGGCCTGATCGCGTCATCGATCGTGCGCCGCTGTGGTGCGCGGTCGACTTACGC GATGGCAACCAGGCGCTGATCGACCCGATGAGCCCGGCCCGCAAGCGCCGCATGTTCGAC CTGCTGGTCCGGATGGGCTACAAGGAGATTGAGGTGGGGTTCCCCTCGGCCAGCCAGACC GACTTCGACTTCGTCAGAGAGATCATCGAGCAGGGCGCCATTCCCGACGACGTCACCATC CAGGTGCTCACCCAATGCCGTCCCGAGCTGATCGAGCGCACCTTCCAGGCGTGTTCGGGC GCACCCCGGGCCATCGTGCACTTCTACAACTCGACGTCAATCCTGCAGCGCCGCGTGGTC TTTCGCGCCAACCGGGCTGAGGTGCAGGCCATCGCGACAGATGGGGCGCGCAAGTGCGTC GAGCAGGCCGCCAAATACCCGGGCACGCAGTGGCGATTCGAGTACTCCCCGGAGTCCTAC ACCGGCACCGAACTGGAATACGCCAAACAGGTGTGCGACGCCGTCGGCGAGGTCATTGCG CCGACGCCGGAGCGCCCGATCATCTTCAACCTGCCCGCCACGGTGGAGATGACGACGCCC AATGTCTACGCCGACTCGATCGAGTGGATGAGCCGCAACCTAGCCAACCGGGAGTCGGTC ATCCTGAGCCTGCACCCGCACAATGACCGCGGAACCGCCGTCGCCGCAGCGGAATTGGGT TTCGCGGCCGGGGCTGATCGGATCGAGGGCTGCCTGTTCGGCAACGGCGAGCGCACCGGC AACGTGTGCCTGGTCACGCTGGGACTCAACCTGTTCTCCCGAGGTGTGGACCCGCAGATC GACTTCTCCAATATTGACGAGATCCGGCGCACGGTGGAGTACTGCAACCAGCTGCCGGTG CACGAACGTCACCCCTATGGCGGCGACCTGGTGTACACCGCGTTCTCCGGTAGCCACCAG GACGCCATCAACAAGGGCCTAGACGCGATGAAGCTGGATGCGGATGCCGCCGACTGTGAC GTCGACGACATGCTGTGGCAGGTGCCGTATCTGCCCATCGACCCGCGCGATGTCGGGCGC ACCTACGAGGCGGTGATCCGGGTCAACTCGCAGTCCGGCAAGGGCGGCGTGGCCTACATC ATGAAGACCGACCACGGCCTTTCCCTGCCGCGGCGGCTGCAGATCGAGTTTTCCCAGGTA ATCCAGAAGATCGCAGAGGGTACAGCAGGCGAGGGTGGCGAGGTCTCGCCCAAGGAGATG TGGGATGCGTTCGCCGAGGAGTATCTGGCCCCGGTGCGGCCTTTGGAGCGGATAAGGCAA CATGTGGACGCTGCCGACGACGACGGCGGCACGACCAGCATCACGGCGACCGTCAAGATC AACGGCGTGGAGACCGAGATCAGCGGGTCCGGTAACGGTCCGTTGGCCGCGTTCGTCCAT GCGCTGGCCGATGTCGGGTTTGACGTGGCCGTGCTGGACTACTACGAGCACGCGATGAGC GCCGGCGACGACGCTCAGGCCGCCGCGTATGTGGAGGCCTCCGTGACGATCGCGAGCCCG GCGCAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGATCGCGAGCCCGGCG CAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGAGTAAGACGGTGTGGGGT GTCGGTATCGCACCGTCAATCACCACCGCGTCGCTGCGCGCCGTGGTGTCGGCGGTCAAC CGGGCGGCACGCTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WQB3 UniProtKB Entry Name LEU1_MYCTU - General References
- Chanchaem W, Palittapongarnpim P: A variable number of tandem repeats result in polymorphic alpha -isopropylmalate synthase in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2002;82(1):1-6. [Article]
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]