2-isopropylmalate synthase

Details

Name
2-isopropylmalate synthase
Synonyms
  • 2.3.3.13
  • Alpha-IPM synthase
  • Alpha-isopropylmalate synthase
Gene Name
leuA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Amino acid sequence
>lcl|BSEQ0051241|2-isopropylmalate synthase
MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN
RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT
DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV
FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA
PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG
FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV
HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR
TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM
WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH
ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA
QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
Number of residues
644
Molecular Weight
70112.945
Theoretical pI
Not Available
GO Classification
Functions
2-isopropylmalate synthase activity / magnesium ion binding / manganese ion binding / potassium ion binding / zinc ion binding
Processes
growth / leucine biosynthetic process
Components
extracellular region / plasma membrane
General Function
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
Specific Function
2-isopropylmalate synthase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0051242|2-isopropylmalate synthase (leuA)
GTGACAACTTCTGAATCGCCCGACGCCTATACCGAGTCGTTTGGGGCCCACACCATCGTG
AAACCCGCCGGCCCACCTCGCGTCGGTCAGCCCTCGTGGAATCCGCAGCGAGCCTCGTCG
ATGCCGGTCAACCGCTACCGGCCGTTCGCCGAGGAGGTCGAGCCCATCCGGCTGAGAAAC
CGCACGTGGCCTGATCGCGTCATCGATCGTGCGCCGCTGTGGTGCGCGGTCGACTTACGC
GATGGCAACCAGGCGCTGATCGACCCGATGAGCCCGGCCCGCAAGCGCCGCATGTTCGAC
CTGCTGGTCCGGATGGGCTACAAGGAGATTGAGGTGGGGTTCCCCTCGGCCAGCCAGACC
GACTTCGACTTCGTCAGAGAGATCATCGAGCAGGGCGCCATTCCCGACGACGTCACCATC
CAGGTGCTCACCCAATGCCGTCCCGAGCTGATCGAGCGCACCTTCCAGGCGTGTTCGGGC
GCACCCCGGGCCATCGTGCACTTCTACAACTCGACGTCAATCCTGCAGCGCCGCGTGGTC
TTTCGCGCCAACCGGGCTGAGGTGCAGGCCATCGCGACAGATGGGGCGCGCAAGTGCGTC
GAGCAGGCCGCCAAATACCCGGGCACGCAGTGGCGATTCGAGTACTCCCCGGAGTCCTAC
ACCGGCACCGAACTGGAATACGCCAAACAGGTGTGCGACGCCGTCGGCGAGGTCATTGCG
CCGACGCCGGAGCGCCCGATCATCTTCAACCTGCCCGCCACGGTGGAGATGACGACGCCC
AATGTCTACGCCGACTCGATCGAGTGGATGAGCCGCAACCTAGCCAACCGGGAGTCGGTC
ATCCTGAGCCTGCACCCGCACAATGACCGCGGAACCGCCGTCGCCGCAGCGGAATTGGGT
TTCGCGGCCGGGGCTGATCGGATCGAGGGCTGCCTGTTCGGCAACGGCGAGCGCACCGGC
AACGTGTGCCTGGTCACGCTGGGACTCAACCTGTTCTCCCGAGGTGTGGACCCGCAGATC
GACTTCTCCAATATTGACGAGATCCGGCGCACGGTGGAGTACTGCAACCAGCTGCCGGTG
CACGAACGTCACCCCTATGGCGGCGACCTGGTGTACACCGCGTTCTCCGGTAGCCACCAG
GACGCCATCAACAAGGGCCTAGACGCGATGAAGCTGGATGCGGATGCCGCCGACTGTGAC
GTCGACGACATGCTGTGGCAGGTGCCGTATCTGCCCATCGACCCGCGCGATGTCGGGCGC
ACCTACGAGGCGGTGATCCGGGTCAACTCGCAGTCCGGCAAGGGCGGCGTGGCCTACATC
ATGAAGACCGACCACGGCCTTTCCCTGCCGCGGCGGCTGCAGATCGAGTTTTCCCAGGTA
ATCCAGAAGATCGCAGAGGGTACAGCAGGCGAGGGTGGCGAGGTCTCGCCCAAGGAGATG
TGGGATGCGTTCGCCGAGGAGTATCTGGCCCCGGTGCGGCCTTTGGAGCGGATAAGGCAA
CATGTGGACGCTGCCGACGACGACGGCGGCACGACCAGCATCACGGCGACCGTCAAGATC
AACGGCGTGGAGACCGAGATCAGCGGGTCCGGTAACGGTCCGTTGGCCGCGTTCGTCCAT
GCGCTGGCCGATGTCGGGTTTGACGTGGCCGTGCTGGACTACTACGAGCACGCGATGAGC
GCCGGCGACGACGCTCAGGCCGCCGCGTATGTGGAGGCCTCCGTGACGATCGCGAGCCCG
GCGCAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGATCGCGAGCCCGGCG
CAGCCGGGCGAAGCGGGTCGGCACGCATCGGACCCCGTGACGAGTAAGACGGTGTGGGGT
GTCGGTATCGCACCGTCAATCACCACCGCGTCGCTGCGCGCCGTGGTGTCGGCGGTCAAC
CGGGCGGCACGCTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP9WQB3
UniProtKB Entry NameLEU1_MYCTU
General References
  1. Chanchaem W, Palittapongarnpim P: A variable number of tandem repeats result in polymorphic alpha -isopropylmalate synthase in Mycobacterium tuberculosis. Tuberculosis (Edinb). 2002;82(1):1-6. [Article]
  2. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
  3. Raman K, Yeturu K, Chandra N: targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis. BMC Syst Biol. 2008 Dec 19;2:109. doi: 10.1186/1752-0509-2-109. [Article]
  4. Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04074alpha-KetoisovalerateexperimentalunknownDetails