Voltage-dependent L-type calcium channel subunit beta-1
Details
- Name
- Voltage-dependent L-type calcium channel subunit beta-1
- Synonyms
- CAB1
- CACNLB1
- Calcium channel voltage-dependent subunit beta 1
- Gene Name
- CACNB1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000603|Voltage-dependent L-type calcium channel subunit beta-1 MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSA ESYTSRPSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVP VQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLDSLRLLQEQKLRQNR LGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQKSTEHVPPYDVVPSMRPIILVGPSLK GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP NPLLNRTMATAALAASPAPVSNLQGPYLASGDQPLERATGEHASMHEYPGELGQPPGLYP SSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGPGLGDPAGGGT PPARQGSWEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELEGWGRGVYIR
- Number of residues
- 598
- Molecular Weight
- 65712.995
- Theoretical pI
- 6.75
- GO Classification
- Functionshigh voltage-gated calcium channel activity / voltage-gated calcium channel activityProcessesaxon guidance / neuromuscular junction development / protein targeting to membrane / regulation of voltage-gated calcium channel activity / synaptic transmission / transportComponentssarcoplasmic reticulum / T-tubule / voltage-gated calcium channel complex
- General Function
- Voltage-gated calcium channel activity
- Specific Function
- The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010071|Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) ATGGTCCAGAAGACCAGCATGTCCCGGGGCCCTTACCCACCCTCCCAGGAGATCCCCATG GAGGTCTTCGACCCCAGCCCGCAGGGCAAATACAGCAAGAGGAAAGGGCGATTCAAACGG TCAGATGGGAGCACGTCCTCGGATACCACATCCAACAGCTTTGTCCGCCAGGGCTCAGCG GAGTCCTACACCAGCCGTCCATCAGACTCTGATGTATCTCTGGAGGAGGACCGGGAAGCC TTAAGGAAGGAAGCAGAGCGCCAGGCATTAGCGCAGCTCGAGAAGGCCAAGACCAAGCCA GTGGCATTTGCTGTGCGGACAAATGTTGGCTACAATCCGTCTCCAGGGGATGAGGTGCCT GTGCAGGGAGTGGCCATCACCTTCGAGCCCAAAGACTTCCTGCACATCAAGGAGAAATAC AATAATGACTGGTGGATCGGGCGGCTGGTGAAGGAGGGCTGTGAGGTTGGCTTCATTCCC AGCCCCGTCAAACTGGACAGCCTTCGCCTGCTGCAGGAACAGAAGCTGCGCCAGAACCGC CTCGGCTCCAGCAAATCAGGCGATAACTCCAGTTCCAGTCTGGGAGATGTGGTGACTGGC ACCCGCCGCCCCACACCCCCTGCCAGTGCCAAACAGAAGCAGAAGTCGACAGAGCATGTG CCCCCCTATGACGTGGTGCCTTCCATGAGGCCCATCATCCTGGTGGGACCGTCGCTCAAG GGCTACGAGGTTACAGACATGATGCAGAAAGCTTTATTTGACTTCTTGAAGCATCGGTTT GATGGCAGGATCTCCATCACTCGTGTGACGGCAGATATTTCCCTGGCTAAGCGCTCAGTT CTCAACAACCCCAGCAAACACATCATCATTGAGCGCTCCAACACACGCTCCAGCCTGGCT GAGGTGCAGAGTGAAATCGAGCGAATCTTCGAGCTGGCCCGGACCCTTCAGTTGGTCGCT CTGGATGCTGACACCATCAATCACCCAGCCCAGCTGTCCAAGACCTCGCTGGCCCCCATC ATTGTTTACATCAAGATCACCTCTCCCAAGGTACTTCAAAGGCTCATCAAGTCCCGAGGA AAGTCTCAGTCCAAACACCTCAATGTCCAAATAGCGGCCTCGGAAAAGCTGGCACAGTGC CCCCCTGAAATGTTTGACATCATCCTGGATGAGAACCAATTGGAGGATGCCTGCGAGCAT CTGGCGGAGTACTTGGAAGCCTATTGGAAGGCCACACACCCGCCCAGCAGCACGCCACCC AATCCGCTGCTGAACCGCACCATGGCTACCGCAGCCCTGGCTGCCAGCCCTGCCCCTGTC TCCAACCTCCAGGGACCCTACCTTGCTTCCGGGGACCAGCCACTGGAACGGGCCACCGGG GAGCACGCCAGCATGCACGAGTACCCAGGGGAGCTGGGCCAGCCCCCAGGCCTTTACCCC AGCAGCCACCCACCAGGCCGGGCAGGCACGCTACGGGCACTGTCCCGCCAAGACACTTTT GATGCCGACACCCCCGGCAGCCGAAACTCTGCCTACACGGAGCTGGGAGACTCATGTGTG GACATGGAGACTGACCCCTCAGAGGGGCCAGGGCTTGGAGACCCTGCAGGGGGCGGCACG CCCCCAGCCCGACAGGGATCCTGGGAGGACGAGGAAGAAGACTATGAGGAAGAGCTGACC GACAACCGGAACCGGGGCCGGAATAAGGCCCGCTACTGCGCTGAGGGTGGGGGTCCAGTT TTGGGGCGCAACAAGAATGAGCTGGAGGGCTGGGGACGAGGCGTCTACATTCGCTGA
- Chromosome Location
- 17
- Locus
- 17q21-q22
- External Identifiers
Resource Link UniProtKB ID Q02641 UniProtKB Entry Name CACB1_HUMAN GenBank Protein ID 179806 GenBank Gene ID M92303 GenAtlas ID CACNB1 HGNC ID HGNC:1401 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00308 Ibutilide approved yes activator Details DB01388 Mibefradil investigational, withdrawn yes inhibitor Details DB04855 Dronedarone approved yes inhibitor Details DB00381 Amlodipine approved unknown inhibitor Details DB00393 Nimodipine approved, investigational yes inhibitor Details DB00898 Ethanol approved unknown Details DB09230 Azelnidipine investigational unknown agonist Details DB11148 Butamben approved, withdrawn yes inhibitor Details DB13746 Bioallethrin approved, experimental unknown agonist Details DB00153 Ergocalciferol approved, nutraceutical no inducer Details DB00228 Enflurane approved, investigational, vet_approved yes inhibitoractivator Details DB00661 Verapamil approved unknown inhibitor Details DB00622 Nicardipine approved, investigational unknown inhibitor Details DB09235 Efonidipine experimental yes inhibitor Details DB06751 Drotaverine approved, investigational unknown inhibitor Details DB11093 Calcium citrate approved, investigational unknown substrate Details DB11348 Calcium Phosphate approved unknown substrate Details DB09089 Trimebutine approved yes inhibitor Details DB09238 Manidipine approved, investigational yes blocker Details DB09236 Lacidipine approved, investigational yes antagonist Details DB09231 Benidipine experimental yes antagonist Details DB09232 Cilnidipine investigational yes antagonist Details DB13746 Bioallethrin approved, experimental unknown blocker Details DB00825 Levomenthol approved yes antagonist Details DB14481 Calcium phosphate dihydrate approved unknown Details DB00252 Phenytoin approved, vet_approved yes inhibitor Details DB00653 Magnesium sulfate approved, investigational, vet_approved yes inhibitorblocker Details DB01054 Nitrendipine approved, investigational unknown inhibitor Details DB00421 Spironolactone approved unknown inhibitor Details DB01118 Amiodarone approved, investigational unknown inhibitor Details DB13961 Fish oil approved, nutraceutical unknown inhibitor Details DB00243 Ranolazine approved, investigational unknown inhibitor Details DB00273 Topiramate approved yes antagonist Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details DB09235 Efonidipine experimental yes blocker Details DB06712 Nilvadipine approved, investigational unknown blocker Details