Proteasome activator complex subunit 1

Details

Name
Proteasome activator complex subunit 1
Synonyms
  • 11S regulator complex subunit alpha
  • Activator of multicatalytic protease subunit 1
  • IFI5111
  • IGUP I-5111
  • Interferon gamma up-regulated I-5111 protein
  • PA28a
  • PA28alpha
  • Proteasome activator 28 subunit alpha
  • REG-alpha
Gene Name
PSME1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049667|Proteasome activator complex subunit 1
MAMLRVQPEAQAKVDVFREDLCTKTENLLGSYFPKKISELDAFLKEPALNEANLSNLKAP
LDIPVPDPVKEKEKEERKKQQEKEDKDEKKKGEDEDKGPPCGPVNCNEKIVVLLQRLKPE
IKDVIEQLNLVTTWLQLQIPRIEDGNNFGVAVQEKVFELMTSLHTKLEGFHTQISKYFSE
RGDAVTKAAKQPHVGDYRQLVHELDEAEYRDIRLMVMEIRNAYAVLYDIILKNFEKLKKP
RGETKGMIY
Number of residues
249
Molecular Weight
28722.9
Theoretical pI
Not Available
GO Classification
Functions
endopeptidase activator activity
Processes
anaphase-promoting complex-dependent catabolic process / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / Fc-epsilon receptor signaling pathway / MAPK cascade / negative regulation of canonical Wnt signaling pathway / negative regulation of G2/M transition of mitotic cell cycle / negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle / NIK/NF-kappaB signaling / positive regulation of canonical Wnt signaling pathway / positive regulation of endopeptidase activity / positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition / proteasome-mediated ubiquitin-dependent protein catabolic process / protein deubiquitination / protein polyubiquitination / regulation of cellular amino acid metabolic process / regulation of G1/S transition of mitotic cell cycle / regulation of mRNA stability / regulation of proteasomal protein catabolic process / regulation of transcription from RNA polymerase II promoter in response to hypoxia / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / stimulatory C-type lectin receptor signaling pathway / T cell receptor signaling pathway / transmembrane transport / tumor necrosis factor-mediated signaling pathway / Wnt signaling pathway, planar cell polarity pathway
Components
cytoplasm / cytosol / extracellular exosome / nucleoplasm / proteasome activator complex / proteasome complex
General Function
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Specific Function
Endopeptidase activator activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0049668|Proteasome activator complex subunit 1 (PSME1)
ATGGCCATGCTCAGGGTCCAGCCCGAGGCCCAAGCCAAGGTGGATGTGTTTCGTGAAGAC
CTCTGTACCAAGACAGAGAACCTGCTCGGGAGCTATTTCCCCAAGAAGATTTCTGAGCTG
GATGCATTTTTAAAGGAGCCAGCTCTCAATGAAGCCAACTTGAGCAATCTGAAGGCCCCA
TTGGACATCCCAGTGCCTGATCCAGTCAAGGAGAAAGAGAAAGAGGAGCGGAAGAAACAG
CAGGAGAAGGAAGACAAGGATGAAAAGAAGAAGGGGGAGGATGAAGACAAAGGTCCTCCC
TGTGGCCCAGTGAACTGCAATGAAAAGATCGTGGTCCTTCTGCAGCGCTTGAAGCCTGAG
ATCAAGGATGTCATTGAGCAGCTCAACCTGGTCACCACCTGGTTGCAGCTGCAGATACCT
CGGATTGAGGATGGTAACAATTTTGGAGTGGCTGTCCAGGAGAAGGTGTTTGAGCTGATG
ACCAGCCTCCACACCAAGCTAGAAGGCTTCCACACTCAAATCTCTAAGTATTTCTCTGAG
CGTGGTGATGCAGTGACTAAAGCAGCCAAGCAGCCCCATGTGGGTGATTATCGGCAGCTG
GTGCACGAGCTGGATGAGGCAGAGTACCGGGACATCCGGCTGATGGTCATGGAGATCCGC
AATGCTTATGCTGTGTTATATGACATCATCCTGAAGAACTTCGAGAAGCTCAAGAAGCCC
AGGGGAGAAACAAAGGGAATGATCTATTGA
Chromosome Location
14
Locus
14q12
External Identifiers
ResourceLink
UniProtKB IDQ06323
UniProtKB Entry NamePSME1_HUMAN
HGNC IDHGNC:9568
General References
  1. Honore B, Leffers H, Madsen P, Celis JE: Interferon-gamma up-regulates a unique set of proteins in human keratinocytes. Molecular cloning and expression of the cDNA encoding the RGD-sequence-containing protein IGUP I-5111. Eur J Biochem. 1993 Dec 1;218(2):421-30. [Article]
  2. Realini C, Dubiel W, Pratt G, Ferrell K, Rechsteiner M: Molecular cloning and expression of a gamma-interferon-inducible activator of the multicatalytic protease. J Biol Chem. 1994 Aug 12;269(32):20727-32. [Article]
  3. McCusker D, Wilson M, Trowsdale J: Organization of the genes encoding the human proteasome activators PA28alpha and beta. Immunogenetics. 1999 May;49(5):438-45. [Article]
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  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Kohda K, Ishibashi T, Shimbara N, Tanaka K, Matsuda Y, Kasahara M: Characterization of the mouse PA28 activator complex gene family: complete organizations of the three member genes and a physical map of the approximately 150-kb region containing the alpha- and beta-subunit genes. J Immunol. 1998 May 15;160(10):4923-35. [Article]
  8. Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. Electrophoresis. 1992 Dec;13(12):960-9. [Article]
  9. Johnston SC, Whitby FG, Realini C, Rechsteiner M, Hill CP: The proteasome 11S regulator subunit REG alpha (PA28 alpha) is a heptamer. Protein Sci. 1997 Nov;6(11):2469-73. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails