Hyaluronan-binding protein 2
Details
- Name
- Hyaluronan-binding protein 2
- Synonyms
- 3.4.21.-
- Factor seven-activating protease
- Factor VII-activating protease
- FSAP
- Hepatocyte growth factor activator-like protein
- HGFAL
- PHBP
- Plasma hyaluronan-binding protein
- Gene Name
- HABP2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008719|Hyaluronan-binding protein 2 MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY TQVTKFLNWIKATIKSESGF
- Number of residues
- 560
- Molecular Weight
- 62671.255
- Theoretical pI
- Not Available
- GO Classification
- Functionsglycosaminoglycan binding / serine-type endopeptidase activityProcessescell adhesion / proteolysisComponentsextracellular region / extracellular space
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0013375|Hyaluronan-binding protein 2 (HABP2) ATGTCTTTATTGGAAAGCCTGGACCCAGACTGGACCCCTGACCAGTATGATTACAGCTAC GAGGATTATAATCAGGAAGAGAACACCAGTAGCACACTTACCCACGCTGAGAATCCTGAC TGGTACTACACTGAGGACCAAGCTGATCCATGCCAGCCCAACCCCTGTGAACACGGTGGG GACTGCCTCGTCCATGGGAGCACCTTCACATGCAGCTGCCTGGCTCCTTTCTCTGGGAAT AAGTGTCAGAAAGTGCAAAATACGTGCAAGGACAACCCATGTGGCCGGGGCCAATGTCTC ATTACCCAGAGTCCTCCCTACTACCGCTGTGTCTGTAAACACCCTTACACAGGTCCCAGC TGCTCCCAAGTGGTTCCTGTATGCAGGCCAAACCCCTGCCAGAATGGGGCTACCTGCTCC CGGCATAAGCGGAGATCCAAGTTCACCTGTGCCTGTCCCGACCAGTTCAAGGGGAAATTC TGTGAAATAGGTTCTGATGACTGCTATGTTGGCGATGGCTACTCTTACCGAGGGAAAATG AATAGGACAGTCAACCAGCATGCGTGCCTTTACTGGAACTCCCACCTCCTCTTGCAGGAG AATTACAACATGTTTATGGAGGATGCTGAAACCCATGGGATTGGGGAACACAATTTCTGC AGAAACCCAGATGCGGACGAAAAGCCCTGGTGCTTTATTAAAGTTACCAATGACAAGGTG AAATGGGAATACTGTGATGTCTCAGCCTGCTCAGCCCAGGACGTTGCCTACCCAGAGGAA AGCCCCACTGAGCCATCAACCAAGCTTCCGGGGTTTGACTCCTGTGGAAAGACTGAGATA GCAGAGAGGAAGATCAAGAGAATCTATGGAGGCTTTAAGAGCACGGCGGGCAAGCACCCA TGGCAGGCGTCCCTCCAGTCCTCGCTGCCTCTGACCATCTCCATGCCCCAGGGCCACTTC TGTGGTGGGGCGCTGATCCACCCCTGCTGGGTGCTCACTGCTGCCCACTGCACCGACATA AAAACCAGACATCTAAAGGTGGTGCTAGGGGACCAGGACCTGAAGAAAGAAGAATTTCAT GAGCAGAGCTTTAGGGTGGAGAAGATATTCAAGTACAGCCACTACAATGAAAGAGATGAG ATTCCCCACAATGATATTGCATTGCTCAAGTTAAAGCCAGTGGATGGTCACTGTGCTCTA GAATCCAAATACGTGAAGACTGTGTGCTTGCCTGATGGGTCCTTTCCCTCTGGGAGTGAG TGCCACATCTCTGGCTGGGGTGTTACAGAAACAGGAAAAGGGTCCCGCCAGCTCCTGGAT GCCAAAGTCAAGCTGATTGCCAACACTTTGTGCAACTCCCGCCAACTCTATGACCACATG ATTGATGACAGTATGATCTGTGCAGGAAATCTTCAGAAACCTGGGCAAGACACCTGCCAG GGTGACTCTGGAGGCCCCCTGACCTGTGAGAAGGACGGCACCTACTACGTCTATGGGATA GTGAGCTGGGGCCTGGAGTGTGGGAAGAGGCCAGGGGTCTACACCCAAGTTACCAAATTC CTGAATTGGATCAAAGCCACCATCAAAAGTGAAAGTGGCTTCTAA
- Chromosome Location
- 10
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q14520 UniProtKB Entry Name HABP2_HUMAN HGNC ID HGNC:4798 - General References
- Choi-Miura NH, Tobe T, Sumiya J, Nakano Y, Sano Y, Mazda T, Tomita M: Purification and characterization of a novel hyaluronan-binding protein (PHBP) from human plasma: it has three EGF, a kringle and a serine protease domain, similar to hepatocyte growth factor activator. J Biochem. 1996 Jun;119(6):1157-65. [Article]
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- Romisch J, Vermohlen S, Feussner A, Stohr H: The FVII activating protease cleaves single-chain plasminogen activators. Haemostasis. 1999;29(5):292-9. [Article]
- Choi-Miura NH, Yoda M, Saito K, Takahashi K, Tomita M: Identification of the substrates for plasma hyaluronan binding protein. Biol Pharm Bull. 2001 Feb;24(2):140-3. [Article]
- Willeit J, Kiechl S, Weimer T, Mair A, Santer P, Wiedermann CJ, Roemisch J: Marburg I polymorphism of factor VII--activating protease: a prominent risk predictor of carotid stenosis. Circulation. 2003 Feb 11;107(5):667-70. [Article]