Interleukin-13 receptor subunit alpha-2

Details

Synonyms

IL-13 receptor subunit alpha-2
IL13R
Interleukin-13-binding protein

Gene Name

IL13RA2

Organism

Humans

Amino acid sequence

>lcl|BSEQ0011732|Interleukin-13 receptor subunit alpha-2
MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD
HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ
SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH
ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP
PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE
TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG
LLLRKPNTYPKMIPEFFCDT

Number of residues

380

Molecular Weight

44176.065

Theoretical pI

4.58

GO Classification

Functions

cytokine receptor activity / signal transducer activity

Processes

cytokine-mediated signaling pathway / immunoglobulin mediated immune response / negative regulation of immunoglobulin production / negative regulation of mast cell degranulation / signal transduction

Components

extracellular space / integral component of membrane

General Function

Signal transducer activity

Specific Function

Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).

Pfam Domain Function

IL6Ra-bind (PF09240)

Transmembrane Regions

344-363

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0011733|Interleukin-13 receptor subunit alpha-2 (IL13RA2)
ATGGCTTTCGTTTGCTTGGCTATCGGATGCTTATATACCTTTCTGATAAGCACAACATTT
GGCTGTACTTCATCTTCAGACACCGAGATAAAAGTTAACCCTCCTCAGGATTTTGAGATA
GTGGATCCCGGATACTTAGGTTATCTCTATTTGCAATGGCAACCCCCACTGTCTCTGGAT
CATTTTAAGGAATGCACAGTGGAATATGAACTAAAATACCGAAACATTGGTAGTGAAACA
TGGAAGACCATCATTACTAAGAATCTACATTACAAAGATGGGTTTGATCTTAACAAGGGC
ATTGAAGCGAAGATACACACGCTTTTACCATGGCAATGCACAAATGGATCAGAAGTTCAA
AGTTCCTGGGCAGAAACTACTTATTGGATATCACCACAAGGAATTCCAGAAACTAAAGTT
CAGGATATGGATTGCGTATATTACAATTGGCAATATTTACTCTGTTCTTGGAAACCTGGC
ATAGGTGTACTTCTTGATACCAATTACAACTTGTTTTACTGGTATGAGGGCTTGGATCAT
GCATTACAGTGTGTTGATTACATCAAGGCTGATGGACAAAATATAGGATGCAGATTTCCC
TATTTGGAGGCATCAGACTATAAAGATTTCTATATTTGTGTTAATGGATCATCAGAGAAC
AAGCCTATCAGATCCAGTTATTTCACTTTTCAGCTTCAAAATATAGTTAAACCTTTGCCG
CCAGTCTATCTTACTTTTACTCGGGAGAGTTCATGTGAAATTAAGCTGAAATGGAGCATA
CCTTTGGGACCTATTCCAGCAAGGTGTTTTGATTATGAAATTGAGATCAGAGAAGATGAT
ACTACCTTGGTGACTGCTACAGTTGAAAATGAAACATACACCTTGAAAACAACAAATGAA
ACCCGACAATTATGCTTTGTAGTAAGAAGCAAAGTGAATATTTATTGCTCAGATGACGGA
ATTTGGAGTGAGTGGAGTGATAAACAATGCTGGGAAGGTGAAGACCTATCGAAGAAAACT
TTGCTACGTTTCTGGCTACCATTTGGTTTCATCTTAATATTAGTTATATTTGTAACCGGT
CTGCTTTTGCGTAAGCCAAACACCTACCCAAAAATGATTCCAGAATTTTTCTGTGATACA
TGA

Chromosome Location

Locus

Xq13.1-q28

External Identifiers

Resource	Link
UniProtKB ID	Q14627
UniProtKB Entry Name	I13R2_HUMAN
GenBank Gene ID	X95302
GenAtlas ID	IL13RA2
HGNC ID	HGNC:5975

General References

Caput D, Laurent P, Kaghad M, Lelias JM, Lefort S, Vita N, Ferrara P: Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J Biol Chem. 1996 Jul 12;271(28):16921-6. [Article]
Guo J, Apiou F, Mellerin MP, Lebeau B, Jacques Y, Minvielle S: Chromosome mapping and expression of the human interleukin-13 receptor. Genomics. 1997 May 15;42(1):141-5. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB05078	AER001	investigational	unknown		Details