Prostaglandin reductase 1
Details
- Name
- Prostaglandin reductase 1
- Synonyms
- 1.3.1.-
- 15-oxoprostaglandin 13-reductase
- LTB4DH
- NADP-dependent leukotriene B4 12-hydroxydehydrogenase
- PRG-1
- Gene Name
- PTGR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007280|Prostaglandin reductase 1 MVRTKTWTLKKHFVGYPTNSDFELKTAELPPLKNGEVLLEALFLTVDPYMRVAAKRLKEG DTMMGQQVAKVVESKNVALPKGTIVLASPGWTTHSISDGKDLEKLLTEWPDTIPLSLALG TVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAVGSDEKVA YLQKLGFDVVFNYKTVESLEETLKKASPDGYDCYFDNVGGEFSNTVIGQMKKFGRIAICG AISTYNRTGPLPPGPPPEIVIYQELRMEAFVVYRWQGDARQKALKDLLKWVLEGKIQYKE YIIEGFENMPAAFMGMLKGDNLGKTIVKA
- Number of residues
- 329
- Molecular Weight
- 35869.64
- Theoretical pI
- 8.53
- GO Classification
- Functions13-prostaglandin reductase activity / 15-oxoprostaglandin 13-oxidase activity / 2-alkenal reductase [NAD(P)] activity / zinc ion bindingProcessesarachidonic acid metabolic process / cyclooxygenase pathway / leukotriene metabolic process / lipoxin metabolic process / response to toxic substance / small molecule metabolic processComponentscytoplasm / extracellular exosome
- General Function
- Zinc ion binding
- Specific Function
- Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha (By similarity). Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.
- Pfam Domain Function
- ADH_zinc_N (PF00107)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012647|Prostaglandin reductase 1 (PTGR1) ATGGTTCGTACTAAGACATGGACCCTGAAGAAGCACTTTGTTGGCTATCCTACTAATAGT GACTTTGAGTTGAAGACAGCTGAGCTCCCACCCTTAAAAAATGGAGAGGTCCTGCTTGAA GCTTTGTTCCTCACCGTGGATCCCTACATGAGAGTGGCAGCCAAAAGATTGAAGGAAGGT GATACAATGATGGGGCAGCAAGTGGCCAAAGTTGTGGAAAGTAAAAATGTAGCCCTACCA AAAGGAACTATTGTACTGGCTTCTCCAGGCTGGACAACGCACTCCATTTCTGATGGGAAA GATCTGGAAAAGCTGCTGACAGAGTGGCCAGACACAATACCACTGTCTTTGGCTCTGGGG ACAGTTGGCATGCCAGGCCTGACTGCCTACTTTGGCCTACTTGAAATCTGTGGTGTGAAG GGTGGAGAAACAGTGATGGTTAATGCAGCAGCTGGAGCTGTGGGCTCAGTCGTGGGGCAG ATTGCAAAGCTCAAGGGCTGCAAAGTTGTTGGAGCAGTAGGGTCTGATGAAAAGGTTGCC TACCTTCAAAAGCTTGGATTTGATGTCGTCTTTAACTACAAGACGGTAGAGTCTTTGGAA GAAACCTTGAAGAAAGCGTCTCCTGATGGTTATGATTGTTATTTTGATAATGTAGGTGGA GAGTTTTCAAACACTGTTATCGGCCAGATGAAGAAATTTGGAAGGATTGCCATATGTGGA GCCATCTCTACATATAACAGAACCGGCCCACTTCCCCCAGGCCCACCCCCAGAGATTGTT ATCTATCAGGAGCTTCGCATGGAAGCTTTTGTCGTCTACCGCTGGCAAGGAGATGCCCGC CAAAAAGCTCTGAAGGACTTGCTGAAATGGGTCTTAGAGGGTAAAATCCAGTACAAGGAA TATATCATTGAAGGATTTGAAAACATGCCAGCTGCATTTATGGGAATGCTGAAAGGAGAT AATTTGGGGAAGACAATAGTGAAAGCATGA
- Chromosome Location
- 9
- Locus
- 9q31.3
- External Identifiers
Resource Link UniProtKB ID Q14914 UniProtKB Entry Name PTGR1_HUMAN GenBank Protein ID 23271371 GenBank Gene ID BC035228 HGNC ID HGNC:18429 - General References
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