Peroxisomal acyl-coenzyme A oxidase 1
Details
- Name
- Peroxisomal acyl-coenzyme A oxidase 1
- Synonyms
- 1.3.3.6
- ACOX
- AOX
- Palmitoyl-CoA oxidase
- SCOX
- Straight-chain acyl-CoA oxidase
- Gene Name
- ACOX1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007874|Peroxisomal acyl-coenzyme A oxidase 1 MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHEDLNFLTRSQRY EVAVRKSAIMVKKMREFGIADPDEIMWFKKLHLVNFVEPVGLNYSMFIPTLLNQGTTAQK EKWLLSSKGLQIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGL GKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYL KMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIA IRYSAVRHQSEIKPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIG QGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTF EGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSP ESLTEAYKLRAARLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFS EKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTEPQITQVNQRVKELLTLIR SDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFEWAKNSPLNKAEVHESYKHLKSLQSKL
- Number of residues
- 660
- Molecular Weight
- 74423.035
- Theoretical pI
- 8.29
- GO Classification
- Functionsacyl-CoA dehydrogenase activity / acyl-CoA oxidase activity / electron carrier activity / FAD binding / fatty-acyl-CoA binding / flavin adenine dinucleotide binding / oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor / palmitoyl-CoA oxidase activity / PDZ domain binding / protein N-terminus binding / receptor bindingProcessesalpha-linolenic acid metabolic process / cellular lipid metabolic process / fatty acid beta-oxidation using acyl-CoA dehydrogenase / fatty acid beta-oxidation using acyl-CoA oxidase / fatty acid oxidation / generation of precursor metabolites and energy / lipid homeostasis / lipid metabolic process / peroxisome fission / positive regulation of cholesterol homeostasis / prostaglandin metabolic process / small molecule metabolic process / spermatogenesis / unsaturated fatty acid metabolic process / very long-chain fatty acid metabolic processComponentsintracellular membrane-bounded organelle / membrane / mitochondrion / nucleolus / nucleoplasm / nucleus / peroxisomal matrix / peroxisomal membrane / peroxisome / plasma membrane
- General Function
- Receptor binding
- Specific Function
- Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Peroxisome
- Gene sequence
>lcl|BSEQ0020740|Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) ATGATCCTGAACGACCCAGACTTCCAGCATGAGGACTTGAACTTCCTCACTCGCAGCCAG CGTTATGAGGTGGCTGTCAGGAAAAGTGCCATCATGGTGAAGAAGATGAGGGAGTTTGGC ATCGCTGACCCTGATGAAATTATGTGGTTTAAAAATTTTGTGCACCGAGGGCGGCCTGAG CCTCTGGATCTTCACTTGGGCATGTTCCTGCCCACCTTGCTTCACCAGGCAACTGCGGAG CAGCAGGAGCGCTTCTTCATGCCCGCCTGGAACTTGGAGATCATTGGCACTTATGCCCAG ACAGAGATGGGTCATGGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCT GAAACCCAGGAGTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGT GGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCAGCTCATCACTAAGGGGAAA TGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTG CCAGGAATTACCGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGC TACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACATGCTGATGAAGTATGCCCAG GTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATG GTGTTTGTCAGGTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACC ATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAATCAAGCCAGGTGAACCAGAA CCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCC TATGCCTTCCAGTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGC ATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGCCCTCACCGCTGGACTGAAG GCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGG CATGGCTATTCTCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGT ACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGCTAGGTTCCTGATGAAAAGT TATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTG CCCAGTCAGCGCATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAAC AGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGCCAGATTAGTAGAAATTGCT GCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTA ACTTCTGTTGACCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTC TTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCAAGCTGTCTTAAGGAGTTTA TGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGC ATCATGACAGAGCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTG ATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTTTCAGGATGTGACACTTGGC TCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAAC TCCCCACTGAACAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCC AAGCTCTGA
- Chromosome Location
- 17
- Locus
- 17q24-q25|17q25.1
- External Identifiers
Resource Link UniProtKB ID Q15067 UniProtKB Entry Name ACOX1_HUMAN GenBank Protein ID 495475 GenBank Gene ID U07866 HGNC ID HGNC:119 - General References
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