Peroxisomal acyl-coenzyme A oxidase 1

Details

Name
Peroxisomal acyl-coenzyme A oxidase 1
Synonyms
  • 1.3.3.6
  • ACOX
  • AOX
  • Palmitoyl-CoA oxidase
  • SCOX
  • Straight-chain acyl-CoA oxidase
Gene Name
ACOX1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007874|Peroxisomal acyl-coenzyme A oxidase 1
MNPDLRRERDSASFNPELLTHILDGSPEKTRRRREIENMILNDPDFQHEDLNFLTRSQRY
EVAVRKSAIMVKKMREFGIADPDEIMWFKKLHLVNFVEPVGLNYSMFIPTLLNQGTTAQK
EKWLLSSKGLQIIGTYAQTEMGHGTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGL
GKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGITVGDIGPKFGYDEIDNGYL
KMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIA
IRYSAVRHQSEIKPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIG
QGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYSHCSGLPNIYVNFTPSCTF
EGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSP
ESLTEAYKLRAARLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFS
EKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTEPQITQVNQRVKELLTLIR
SDAVALVDAFDFQDVTLGSVLGRYDGNVYENLFEWAKNSPLNKAEVHESYKHLKSLQSKL
Number of residues
660
Molecular Weight
74423.035
Theoretical pI
8.29
GO Classification
Functions
acyl-CoA dehydrogenase activity / acyl-CoA oxidase activity / electron carrier activity / FAD binding / fatty-acyl-CoA binding / flavin adenine dinucleotide binding / oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor / palmitoyl-CoA oxidase activity / PDZ domain binding / protein N-terminus binding / receptor binding
Processes
alpha-linolenic acid metabolic process / cellular lipid metabolic process / fatty acid beta-oxidation using acyl-CoA dehydrogenase / fatty acid beta-oxidation using acyl-CoA oxidase / fatty acid oxidation / generation of precursor metabolites and energy / lipid homeostasis / lipid metabolic process / peroxisome fission / positive regulation of cholesterol homeostasis / prostaglandin metabolic process / small molecule metabolic process / spermatogenesis / unsaturated fatty acid metabolic process / very long-chain fatty acid metabolic process
Components
intracellular membrane-bounded organelle / membrane / mitochondrion / nucleolus / nucleoplasm / nucleus / peroxisomal matrix / peroxisomal membrane / peroxisome / plasma membrane
General Function
Receptor binding
Specific Function
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Peroxisome
Gene sequence
>lcl|BSEQ0020740|Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)
ATGATCCTGAACGACCCAGACTTCCAGCATGAGGACTTGAACTTCCTCACTCGCAGCCAG
CGTTATGAGGTGGCTGTCAGGAAAAGTGCCATCATGGTGAAGAAGATGAGGGAGTTTGGC
ATCGCTGACCCTGATGAAATTATGTGGTTTAAAAATTTTGTGCACCGAGGGCGGCCTGAG
CCTCTGGATCTTCACTTGGGCATGTTCCTGCCCACCTTGCTTCACCAGGCAACTGCGGAG
CAGCAGGAGCGCTTCTTCATGCCCGCCTGGAACTTGGAGATCATTGGCACTTATGCCCAG
ACAGAGATGGGTCATGGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCT
GAAACCCAGGAGTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGT
GGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCAGCTCATCACTAAGGGGAAA
TGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTG
CCAGGAATTACCGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGC
TACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACATGCTGATGAAGTATGCCCAG
GTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATG
GTGTTTGTCAGGTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACC
ATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAATCAAGCCAGGTGAACCAGAA
CCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCC
TATGCCTTCCAGTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGC
ATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGCCCTCACCGCTGGACTGAAG
GCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGG
CATGGCTATTCTCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGT
ACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGCTAGGTTCCTGATGAAAAGT
TATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTG
CCCAGTCAGCGCATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAAC
AGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGCCAGATTAGTAGAAATTGCT
GCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTA
ACTTCTGTTGACCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTC
TTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCAAGCTGTCTTAAGGAGTTTA
TGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGC
ATCATGACAGAGCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTG
ATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTTTCAGGATGTGACACTTGGC
TCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAAC
TCCCCACTGAACAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCC
AAGCTCTGA
Chromosome Location
17
Locus
17q24-q25|17q25.1
External Identifiers
ResourceLink
UniProtKB IDQ15067
UniProtKB Entry NameACOX1_HUMAN
GenBank Protein ID495475
GenBank Gene IDU07866
HGNC IDHGNC:119
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03147Flavin adenine dinucleotideapprovedunknownDetails
DB07930(3R)-3-HYDROXYDODECANOIC ACIDexperimentalunknownDetails
DB09328Vayarinapproved, investigationalunknownsubstrateDetails