Guanylate kinase
Details
- Name
- Guanylate kinase
- Synonyms
- 2.7.4.8
- GMK
- GMP kinase
- Gene Name
- GUK1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004617|Guanylate kinase MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE LKEALSEEIKKAQRTGA
- Number of residues
- 197
- Molecular Weight
- 21725.41
- Theoretical pI
- 6.53
- GO Classification
- FunctionsATP binding / guanylate kinase activityProcessesATP metabolic process / dATP metabolic process / dGDP biosynthetic process / dGMP metabolic process / drug metabolic process / GDP biosynthetic process / GDP-mannose metabolic process / glycoprotein transport / nucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / purine nucleotide metabolic process / small molecule metabolic processComponentscytosol
- General Function
- Guanylate kinase activity
- Specific Function
- Essential for recycling GMP and indirectly, cGMP.
- Pfam Domain Function
- Guanylate_kin (PF00625)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011690|Guanylate kinase (GUK1) ATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCACCCTG CTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACG AGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTG ATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCCGAGTTCTCGGGGAACCTG TATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTG GACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATC TCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTGCGGCAGCGCAACACTGAA ACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCAGCAAG GAGCCCGGCCTGTTTGATGTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAG CTGAAGGAGGCGCTCTCTGAGGAAATCAAGAAAGCTCAAAGGACCGGCGCCTGA
- Chromosome Location
- 1
- Locus
- 1q32-q41
- External Identifiers
Resource Link UniProtKB ID Q16774 UniProtKB Entry Name KGUA_HUMAN GenBank Protein ID 1196436 GenBank Gene ID L76200 GenAtlas ID GUK1 HGNC ID HGNC:4693 - General References
- Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM: Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation. FEBS Lett. 1996 May 6;385(3):185-8. [Article]
- Brady WA, Kokoris MS, Fitzgibbon M, Black ME: Cloning, characterization, and modeling of mouse and human guanylate kinases. J Biol Chem. 1996 Jul 12;271(28):16734-40. [Article]
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