D-hydantoinase

Details

Name
D-hydantoinase
Synonyms
  • 3.5.2.-
Gene Name
Not Available
Organism
Geobacillus stearothermophilus
Amino acid sequence
>lcl|BSEQ0011221|D-hydantoinase
MTKLIKNGTIVTATDIYEADLLIQDGKIAVIGRNLDESGAEVIDATGCYVFPGGIDPHTH
LDMPFGGTVTKDDFESGTIAAAFGGTTTIIDFCLTNKGEPLKKAIETWHNKATGKAVIDY
GFHLMISEITDDVLEELPKVIEEEGITSFKVFMAYKDVFQADDGTLYRTLVAAKELGALV
MVHAENGDVIDYLTKKALEDGHTDPIYHALTRPPELEGEATGRACQLTELAGSQLYVVHV
SCAQAVEKIAEARNKGLNVWGETCPQYLVLDQSYLEKPNFEGAKYVWSPPLREKWHQEVL
WNALKNGQLQTLGSDQCSFDFKGQKELGRGDFTKIPNGGPIIEDRVSILFSEGVKKGRIT
LNQFVDIVSTRIAKLFGLFPKKGTIAVGADADLVIFDPTVERVISAETHHMAVDYNPFEG
MKVTGEPVSVLCRGEFVVRDKQFVGKPGYGQYVKRAKYGALMADQDVVKMS
Number of residues
471
Molecular Weight
51724.68
Theoretical pI
4.93
GO Classification
Functions
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds / metal ion binding
Components
cytoplasm
General Function
Metal ion binding
Specific Function
Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0003400|1416 bp
ATGACAAAATTGATAAAAAATGGAACAATTGTCACCGCTACAGATATATATGAAGCCGAT
CTCCTCATTCAAGATGGGAAAATTGCAGTAATCGGGAGAAATTTAGATGAGAGCGGAGCG
GAAGTGATTGATGCCACAGGTTGTTATGTGTTTCCAGGAGGCATTGATCCGCACACCCAT
TTAGATATGCCGTTTGGCGGCACTGTGACAAAAGACGACTTTGAGTCGGGGACGATTGCC
GCCGCATTTGGCGGGACGACGACCATTATTGATTTTTGCTTAACGAATAAAGGTGAGCCC
CTGAAAAAAGCGATTGAAACTTGGCATAACAAAGCGACGGGGAAAGCGGTGATCGATTAC
GGGTTCCATTTGATGATCAGTGAAATAACGGACGATGTGCTTGAAGAGCTTCCAAAAGTG
ATCGAAGAAGAAGGAATTACCTCCTTTAAAGTATTTATGGCGTATAAAGATGTGTTTCAA
GCTGATGATGGAACCTTGTATCGGACGCTAGTCGCGGCAAAAGAACTCGGAGCGCTTGTC
ATGGTGCATGCCGAGAATGGAGACGTGATTGACTATTTAACGAAAAAAGCCTTGGAGGAC
GGGCATACTGATCCGATTTATCATGCATTAACGAGACCTCCAGAGCTAGAAGGAGAAGCG
ACGGGGCGCGCCTGTCAATTGACAGAACTCGCTGGTTCGCAATTGTACGTCGTTCATGTA
TCGTGTGCTCAAGCGGTAGAGAAAATTGCTGAAGCGCGCAATAAGGGGTTGAATGTATGG
GGCGAAACTTGTCCCCAGTATCTGGTGCTCGATCAGTCCTATTTAGAAAAGCCGAATTTT
GAAGGTGCTAAATATGTATGGTCACCGCCGCTTCGTGAGAAATGGCATCAAGAAGTGCTA
TGGAATGCCTTGAAAAACGGCCAGCTGCAAACGCTCGGATCTGACCAATGCTCATTTGAT
TTTAAAGGCCAAAAAGAATTAGGAAGGGGAGATTTTACCAAAATCCCAAATGGTGGTCCT
ATTATTGAGGATCGGGTGAGTATTCTTTTCAGTGAAGGAGTGAAAAAAGGGAGAATTACC
CTCAACCAGTTTGTTGATATTGTATCAACAAGAATCGCCAAATTGTTTGGTCTATTCCCG
AAGAAAGGAACCATTGCCGTCGGTGCGGATGCGGATTTAGTCATTTTTGATCCAACGGTT
GAACGGGTGATTTCAGCCGAAACACACCATATGGCTGTGGATTATAATCCGTTTGAAGGG
ATGAAAGTAACAGGGGAACCTGTGTCGGTTTTATGTAGAGGAGAATTTGTGGTACGTGAT
AAACAATTTGTCGGGAAACCGGGGTACGGCCAATATGTTAAACGCGCGAAATATGGGGCG
CTAATGGCCGACCAAGATGTGGTGAAAATGTCCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ45515
UniProtKB Entry NameHYDA_GEOSE
GenBank Protein ID688288
GenBank Gene IDS73773
General References
  1. Mukohara Y, Ishikawa T, Watabe K, Nakamura H: A thermostable hydantoinase of Bacillus stearothermophilus NS1122A: cloning, sequencing, and high expression of the enzyme gene, and some properties of the expressed enzyme. Biosci Biotechnol Biochem. 1994 Sep;58(9):1621-6. [Article]
  2. Cheon YH, Kim HS, Han KH, Abendroth J, Niefind K, Schomburg D, Wang J, Kim Y: Crystal structure of D-hydantoinase from Bacillus stearothermophilus: insight into the stereochemistry of enantioselectivity. Biochemistry. 2002 Jul 30;41(30):9410-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03801Lysine Nz-Carboxylic AcidexperimentalunknownDetails