Diacetyl reductase [(S)-acetoin forming]
Details
- Name
- Diacetyl reductase [(S)-acetoin forming]
- Synonyms
- 1.1.1.304
- Acetoin(diacetyl) reductase
- AR
- Meso-2,3-butanediol dehydrogenase
- Gene Name
- budC
- Organism
- Klebsiella pneumoniae
- Amino acid sequence
>lcl|BSEQ0011868|Diacetyl reductase [(S)-acetoin forming] MKKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGGRAMAVKVDV SDRDQVFAAVEQARKTLGGFDVIVNNAGVAPSTPIESITPEIVDKVYNINVKGVIWGIQA AVEAFKKEGHGGKIINACSQAGHVGNPELAVYSSSKFAVRGLTQTAARDLAPLGITVNGY CPGIVKTPMWAEIDRQVSEAAGKPLGYGTAEFAKRITLGRLSEPEDVAACVSYLASPDSD YMTGQSLLIDGGMVFN
- Number of residues
- 256
- Molecular Weight
- 26642.245
- Theoretical pI
- 6.53
- GO Classification
- Functionsdiacetyl reductase ((S)-acetoin forming) activityProcessesacetoin catabolic process
- General Function
- Diacetyl reductase ((s)-acetoin forming) activity
- Specific Function
- Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0005167|771 bp ATGAAAAAAGTCGCACTTGTTACCGGCGCCGGCCAGGGGATTGGTAAAGCTATCGCCCTT CGTCTGGTGAAGGATGGATTTGCCGTGGCCATTGCCGATTATAACGACGCCACCGCCAAA GCGGTCGCCTCGGAAATCAACCAGGCCGGCGGACACGCCGTGGCGGTGAAAGTGGATGTC TCCGACCGCGATCAGGTATTTGCCGCCGTTGAACAGGCGCGCAAAACGCTGGGCGGCTTC GACGTCATCGTCAATAACGCCGGTGTGGCACCGTCTACGCCGATCGAGTCCATTACCCCG GAGATTGTCGACAAAGTCTACAACATCAACGTCAAAGGGGTGATCTGGGGTATTCAGGCG GCGGTCGAGGCCTTTAAGAAAGAGGGGCACGGCGGGAAAATCATCAACGCCTGTTCCCAG GCCGGCCACGTCGGCAACCCGGAGCTGGCGGTGTATAGCTCCAGTAAATTCGCGGTACGC GGCTTAACCCAGACCGCCGCTCGCGACCTCGCGCCGCTGGGCATCACGGTCAACGGCTAC TGCCCGGGGATTGTCAAAACGCCAATGTGGGCCGAAATTGACCGCCAGGTGTCCGAAGCC GCCGGTAAACCGCTGGGCTACGGTACCGCCGAGTTCGCCAAACGCATCACTCTCGGTCGT CTGTCCGAGCCGGAAGATGTCGCCGCCTGCGTCTCCTATCTTGCCAGCCCGGATTCTGAT TACATGACCGGTCAGTCGTTGCTGATCGACGGCGGGATGGTATTTAACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q48436 UniProtKB Entry Name BUDC_KLEPN GenBank Gene ID D86412 - General References
- Wardwell SA, Yang YT, Chang HY, San KY, Rudolph FB, Bennett GN: Expression of the Klebsiella pneumoniae CG21 acetoin reductase gene in Clostridium acetobutylicum ATCC 824. J Ind Microbiol Biotechnol. 2001 Oct;27(4):220-7. [Article]
- Otagiri M, Kurisu G, Ui S, Takusagawa Y, Ohkuma M, Kudo T, Kusunoki M: Crystal structure of meso-2,3-butanediol dehydrogenase in a complex with NAD+ and inhibitor mercaptoethanol at 1.7 A resolution for understanding of chiral substrate recognition mechanisms. J Biochem. 2001 Feb;129(2):205-8. [Article]