Proton-coupled amino acid transporter 2
Details
- Name
- Proton-coupled amino acid transporter 2
- Synonyms
- PAT2
- Proton/amino acid transporter 2
- Solute carrier family 36 member 2
- TRAMD1
- Tramdorin-1
- Gene Name
- SLC36A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008555|Proton-coupled amino acid transporter 2 MSVTKSTEGPQGAVAIKLDLMSPPESAKKLENKDSTFLDESPSESAGLKKTKGITVFQAL IHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAQRFCKRLNKPF MDYGDTVMHGLEANPNAWLQNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAV NSTTNNCYSNETVILTPTMDSRLYMLSFLPFLVLLVLIRNLRILTIFSMLANISMLVSLV IIIQYITQEIPDPSRLPLVASWKTYPLFFGTAIFSFESIGVVLPLENKMKNARHFPAILS LGMSIVTSLYIGMAALGYLRFGDDIKASISLNLPNCWLYQSVKLLYIAGILCTYALQFYV PAEIIIPFAISRVSTRWALPLDLSIRLVMVCLTCLLAILIPRLDLVISLVGSVSGTALAL IIPPLLEVTTFYSEGMSPLTIFKDALISILGFVGFVVGTYQALDELLKSEDSHPFSNSTT FVR
- Number of residues
- 483
- Molecular Weight
- 53215.65
- Theoretical pI
- Not Available
- GO Classification
- Functionsglycine transmembrane transporter activity / hydrogen / hydrogen ion transmembrane transporter activity / L-alanine transmembrane transporter activity / L-proline transmembrane transporter activityProcessesamino acid transport / glycine transport / hydrogen ion transmembrane transport / ion transport / L-alanine transport / proline transmembrane transport / proton transport / transmembrane transportComponentsextracellular exosome / integral component of membrane / plasma membrane / vacuolar membrane
- General Function
- L-proline transmembrane transporter activity
- Specific Function
- Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids. Transports glycine and proline. Inhibited by sarcosine (By similarity).
- Pfam Domain Function
- Aa_trans (PF01490)
- Transmembrane Regions
- 59-79 82-102 149-169 198-218 223-243 265-285 297-317 350-370 380-400 405-425 438-458
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0013270|Proton-coupled amino acid transporter 2 (SLC36A2) ATGTCTGTGACAAAAAGTACTGAGGGTCCCCAGGGAGCCGTTGCCATCAAATTGGACCTT ATGTCGCCTCCTGAAAGTGCCAAGAAGTTGGAGAACAAGGACTCTACATTCTTGGATGAA AGTCCTTCAGAGTCAGCAGGCTTGAAGAAGACCAAGGGCATAACAGTGTTCCAGGCCTTG ATTCACCTGGTGAAAGGCAACATGGGCACAGGGATCCTGGGACTACCCCTCGCTGTGAAG AACGCGGGCATCCTGATGGGCCCACTCAGTCTGCTGGTGATGGGCTTCATTGCCTGCCAC TGTATGCACATCCTGGTCAAGTGTGCCCAGCGCTTCTGTAAGAGGCTTAACAAGCCCTTT ATGGACTATGGGGACACGGTGATGCATGGACTAGAAGCCAACCCCAACGCCTGGCTCCAG AATCACGCTCACTGGGGAAGGCATATCGTGAGCTTCTTCCTTATTATCACCCAACTTGGC TTCTGCTGTGTGTACATTGTGTTTTTGGCTGATAATTTAAAACAGGTAGTGGAAGCTGTT AATAGCACAACCAACAACTGCTATTCCAATGAGACGGTGATTCTGACCCCCACCATGGAC TCGCGACTCTACATGCTCTCCTTCCTGCCCTTCCTGGTGCTGCTGGTCCTCATCCGGAAC CTCAGGATCTTGACCATCTTCTCCATGCTGGCCAACATCAGCATGCTGGTCAGCTTGGTC ATCATCATACAGTACATTACCCAGGAAATCCCAGACCCCAGCCGGTTGCCACTGGTAGCA AGCTGGAAGACCTACCCTCTCTTCTTCGGAACAGCCATTTTTTCTTTTGAAAGCATTGGT GTGGTTCTGCCTCTGGAAAACAAGATGAAGAATGCCCGCCACTTCCCAGCCATCCTGTCT TTGGGAATGTCCATCGTCACTTCCCTATACATTGGCATGGCGGCTCTGGGCTACCTGCGG TTTGGAGATGACATCAAGGCCAGCATAAGCCTTAACCTGCCTAACTGCTGGCTGTACCAG TCTGTCAAGCTTCTCTACATTGCCGGCATCCTGTGCACCTATGCCCTGCAGTTCTACGTC CCTGCAGAAATCATCATCCCCTTTGCCATCTCCCGGGTGTCAACACGCTGGGCACTGCCT CTGGATCTGTCCATTCGCCTCGTCATGGTCTGCCTGACATGCCTCCTGGCCATCCTCATC CCCCGCCTGGACCTGGTCATCTCCCTGGTGGGCTCCGTGAGTGGCACCGCCCTGGCCCTC ATCATCCCACCGCTCCTGGAGGTCACCACGTTCTACTCAGAGGGCATGAGCCCCCTCACC ATCTTCAAGGACGCCCTGATCAGCATCCTGGGCTTCGTGGGCTTTGTGGTGGGGACCTAC CAGGCCCTGGACGAGCTGCTCAAGTCAGAAGACTCTCACCCCTTTTCCAACTCCACCACT TTTGTTCGGTGA
- Chromosome Location
- 5
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q495M3 UniProtKB Entry Name S36A2_HUMAN HGNC ID HGNC:18762 - General References
- Boll M, Foltz M, Rubio-Aliaga I, Daniel H: A cluster of proton/amino acid transporter genes in the human and mouse genomes. Genomics. 2003 Jul;82(1):47-56. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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- Bermingham JR Jr, Pennington J: Organization and expression of the SLC36 cluster of amino acid transporter genes. Mamm Genome. 2004 Feb;15(2):114-25. [Article]
- Broer S, Bailey CG, Kowalczuk S, Ng C, Vanslambrouck JM, Rodgers H, Auray-Blais C, Cavanaugh JA, Broer A, Rasko JE: Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. J Clin Invest. 2008 Dec;118(12):3881-92. doi: 10.1172/JCI36625. Epub 2008 Nov 6. [Article]