Chitobiase

Details

Name
Chitobiase
Synonyms
  • 3.2.1.52
  • Beta-N-acetylhexosaminidase
  • N-acetyl-beta-glucosaminidase
Gene Name
chb
Organism
Serratia marcescens
Amino acid sequence
>lcl|BSEQ0020549|Chitobiase
MNAFKLSALARLTATMGFLGGMGSAMADQQLVDQLSQLKLNVKMLDNRAGENGVDCAALG
ADWASCNRVLFTLSNDGQAIDGKDWVIYFHSPRQTLRVDNDQFKIAHLTGDLYKLEPTAK
FSGFPAGKAVEIPVVAEYWQLFRNDFLPRWYATSGDAKPKMLANTDTENLDQFVAPFTGD
QWKRTKDDKNILMTPASRFVSNADLQTLPAGALRGKIVPTPMQVKVHAQDADLRKGVALD
LSTLVKPAADVVSQRFALLGVPVQTNGYPIKTDIQPGKFKGAMAVSGAYELKIGKKEAQV
IGFDQAGVFYGLQSILSLVPSDGSGKIATLDASDAPRFPYRGIFLDVARNFHKKDAVLRL
LDQMAAYKLNKFHFHLSDDEGWRIEIPGLPELTEVGGQRCHDLSETTCLLPQYGQGPDVY
GGFFSRQDYIDIIKYAQARQIEVIPEIDMPAHARAAVVSMEARYKKLHAAGKEQEANEFR
LVDPTDTSNTTSVQFFNRQSYLNPCLDSSQRFVDKVIGEIAQMHKEAGQPIKTWHFGGDE
AKNIRLGAGYTDKAKPEPGKGIIDQSNEDKPWAKSQVCQTMIKEGKVADMEHLPSYFGQE
VSKLVKAHGIDRMQAWQDGLKDAESSKAFATSRVGVNFWDTLYWGGFDSVNDWANKGYEV
VVSNPDYVYMDFPYEVNPDERGYYWGTRFSDERKVFSFAPDNMPQNAETSVDRDGNHFNA
KSDKPWPGAYGLSAQLWSETQRTDPQMEYMIFPRALSVAERSWHRAGWEQDYRAGREYKG
GETHFVDTQALEKDWLRFANILGQRELAKLDKGGVAYRLPVPGARVAAGKLEANIALPGL
GIEYSTDGGKQWQRYDAKAKPAVSGEVQVRSVSPDGKRYSRAEKV
Number of residues
885
Molecular Weight
98547.55
Theoretical pI
6.73
GO Classification
Functions
beta-N-acetylhexosaminidase activity / polysaccharide binding
Processes
chitin catabolic process / polysaccharide catabolic process
Components
periplasmic space
General Function
Polysaccharide binding
Specific Function
Digests the beta-1,4-glycosidic bonds in N-acetylglucosamine (GlcNAc) oligomers (mainly dimers).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Periplasm
Gene sequence
>lcl|BSEQ0003184|2658 bp
ATGAACGCATTCAAACTGAGCGCGCTTGCCCGCTTGACGGCAACGATGGGATTCCTGGGC
GGTATGGGGAGCGCCATGGCCGATCAACAGCTGGTGGATCAACTGAGCCAGCTGAAGCTG
AACGTGAAAATGCTGGATAACCGCGCCGGCGAAAACGGCGTGGATTGCGCGGCGCTGGGC
GCTGACTGGGCTTCTTGCAACCGGGTGTTGTTCACCCTCAGCAACGACGGCCAGGCGATC
GACGGCAAAGACTGGGTCATCTATTTCCACAGCCCGCGGCAGACCTTGCGGGTGGACAAC
GACCAGTTCAAGATCGCGCATCTGACCGGCGATCTGTACAAGCTGGAGCCGACCGCCAAA
TTCAGCGGTTTCCCGGCCGGTAAGGCGGTGGAAATCCCGGTGGTCGCCGAATACTGGCAG
CTGTTCAGAAACGACTTCCTGCCGCGTTGGTATGCCACCTCCGGCGACGCCAAGCCGAAA
ATGCTGGCGAATACCGACACCGAAAACCTGGATCAGTTTGTGGCGCCGTTCACCGGCGAC
CAGTGGAAGCGCACCAAGGACGACAAAAACATTCTGATGACGCCGGCTTCGCGCTTTGTC
AGCAATGCCGATCTGCAGACGCTGCCCGCCGGCGCGCTGCGCGGCAAGATCGTGCCGACG
CCGATGCAGGTGAAGGTCCACGCACAGGACGCCGACCTGCGCAAAGGGGTGGCGCTGGAT
CTGAGCACGCTGGTCAAGCCGGCGGCGGACGTCGTCAGTCAGCGTTTCGCGCTGCTGGGC
GTGCCGGTTCAGACCAACGGTTACCCGATCAAGACCGATATCCAGCCGGGCAAGTTTAAA
GGCGCGATGGCGGTATCGGGCGCCTATGAGCTGAAAATCGGCAAGAAAGAGGCGCAAGTG
ATCGGCTTCGATCAGGCCGGGGTGTTCTACGGGCTGCAGTCGATCCTGTCGTTAGTGCCG
AGCGACGGCAGCGGCAAGATCGCCACGCTGGACGCCAGCGATGCGCCGCGCTTCCCGTAT
CGCGGCATTTTCCTCGACGTGGCGCGCAACTTCCATAAGAAGGACGCGGTGCTGCGTCTG
CTGGATCAGATGGCGGCTTACAAGCTCAATAAATTCCACTTCCACCTGAGCGATGACGAA
GGCTGGCGCATCGAGATCCCCGGCTTGCCTGAGTTGACGGAAGTCGGCGGCCAGCGCTGC
CACGATCTGAGCGAAACCACCTGCCTGCTGCCGCAGTACGGCCAGGGGCCGGACGTCTAC
GGCGGCTTCTTCAGCCGTCAGGACTACATCGACATCATCAAATACGCCCAGGCGCGCCAG
ATTGAGGTGATCCCGGAGATCGACATGCCGGCGCACGCGCGCGCCGCGGTGGTTTCGATG
GAAGCGCGCTATAAAAAGCTGCATGCCGCTGGCAAAGAGCAGGAGGCCAACGAATTCCGT
CTGGTGGATCCGACCGATACCTCCAACACCACCTCCGTGCAGTTCTTTAACCGCCAGAGC
TACCTGAACCCGTGCCTGGATTCCTCCCAGCGCTTTGTCGACAAGGTGATCGGCGAGATT
GCCCAGATGCATAAAGAAGCCGGGCAGCCGATCAAGACCTGGCACTTTGGCGGCGATGAG
GCGAAAAACATCCGCCTGGGCGCCGGCTATACCGACAAGGCGAAACCGGAACCGGGTAAA
GGCATCATTGACCAGAGTAATGAAGACAAGCCGTGGGCCAAGTCGCAGGTGTGCCAGACG
ATGATCAAAGAGGGCAAAGTAGCCGACATGGAGCACCTGCCGAGCTACTTCGGCCAGGAG
GTCAGCAAGCTGGTGAAGGCGCACGGCATCGATAGAATGCAGGCCTGGCAAGACGGCCTG
AAAGACGCCGAAAGTTCGAAGGCGTTCGCCACCTCGCGCGTGGGCGTCAACTTCTGGGAC
ACCCTGTATTGGGGCGGTTTCGACAGCGTTAACGACTGGGCCAATAAAGGGTATGAAGTG
GTGGTCTCCAACCCGGACTACGTCTACATGGACTTCCCTTACGAGGTGAATCCGGACGAG
CGCGGTTACTACTGGGGCACCCGCTTCAGCGACGAGCGCAAGGTGTTCAGCTTCGCGCCG
GACAACATGCCGCAGAACGCGGAAACCTCGGTCGACCGCGACGGCAACCACTTCAACGCC
AAAAGCGACAAGCCGTGGCCGGGCGCCTACGGTCTGTCCGCTCAGCTGTGGAGCGAAACC
CAGCGCACCGATCCGCAGATGGAATACATGATCTTCCCGCGCGCGCTTTCGGTGGCGGAA
CGGTCCTGGCACCGCGCCGGTTGGGAGCAGGACTATCGCGCCGGCCGCGAATACAAAGGC
GGGGAAACCCACTTTGTCGATACCCAGGCGCTGGAGAAAGACTGGCTGCGCTTCGCCAAT
ATCCTGGGCCAACGTGAACTGGCCAAGCTGGACAAAGGCGGCGTCGCTTATCGTCTGCCG
GTGCCGGGTGCCCGCGTGGCGGCTGGCAAGCTGGAAGCGAATATCGCGCTGCCGGGATTG
GGCATCGAGTATTCCACCGACGGCGGCAAGCAGTGGCAGCGCTATGACGCCAAGGCCAAG
CCGGCGGTCTCCGGTGAAGTGCAGGTGCGTTCGGTCAGCCCGGACGGTAAACGCTACAGC
CGCGCCGAGAAGGTCTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ54468
UniProtKB Entry NameCHB_SERMA
GenBank Protein ID1369888
GenBank Gene IDL43594
General References
  1. Tews I, Vincentelli R, Vorgias CE: N-Acetylglucosaminidase (chitobiase) from Serratia marcescens: gene sequence, and protein production and purification in Escherichia coli. Gene. 1996 Apr 17;170(1):63-7. [Article]
  2. Tews I, Perrakis A, Oppenheim A, Dauter Z, Wilson KS, Vorgias CE: Bacterial chitobiase structure provides insight into catalytic mechanism and the basis of Tay-Sachs disease. Nat Struct Biol. 1996 Jul;3(7):638-48. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03013N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosamineexperimentalunknownDetails