Delta-aminolevulinic acid dehydratase

Details

Name
Delta-aminolevulinic acid dehydratase
Synonyms
  • 4.2.1.24
  • ALAD
  • Porphobilinogen synthase
Gene Name
hemB
Organism
Chlorobaculum parvum (strain NCIB 8327)
Amino acid sequence
>lcl|BSEQ0011428|Delta-aminolevulinic acid dehydratase
MSQLDLLNIVHRPRRLRRTAALRNLVQENTLTVNDLVFPLFVMPGTNAVEEVSSMPGSFR
FTIDRAVEECKELYDLGIQGIDLFGIPEQKTEDGSEAYNDNGILQQAIRAIKKAVPELCI
MTDVALDPFTPFGHDGLVKDGIILNDETVEVLQKMAVSHAEAGADFVSPSDMMDGRIGAI
REALDETDHSDVGILSYAAKYASSFYGPFRDALHSAPQFGDKSTYQMNPANTEEAMKEVE
LDIVEGADIVMVKPGLAYLDIVWRTKERFDVPVAIYHVSGEYAMVKAAAAKGWIDEDRVM
MESLLCMKRAGADIIFTYYAKEAAKKLR
Number of residues
328
Molecular Weight
36394.215
Theoretical pI
4.53
GO Classification
Functions
metal ion binding / porphobilinogen synthase activity
Processes
protoporphyrinogen IX biosynthetic process
General Function
Porphobilinogen synthase activity
Specific Function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0011429|Delta-aminolevulinic acid dehydratase (hemB)
ATGAGCCAGCTCGACCTCCTCAATATTGTGCATCGCCCGAGAAGACTTCGCAGAACCGCA
GCGCTCCGCAACCTTGTGCAGGAAAACACGCTGACGGTCAACGATCTTGTGTTCCCCCTG
TTCGTCATGCCCGGCACCAACGCCGTTGAAGAGGTTTCATCCATGCCCGGCAGCTTCCGC
TTCACCATCGACCGCGCTGTCGAAGAGTGCAAGGAGCTTTACGATCTCGGCATCCAGGGC
ATCGATCTGTTCGGCATTCCGGAGCAGAAAACCGAAGACGGCAGCGAAGCCTACAACGAC
AACGGCATTCTTCAGCAGGCCATCCGCGCCATCAAGAAAGCCGTGCCGGAGCTGTGCATC
ATGACCGACGTTGCACTTGACCCGTTCACCCCATTCGGCCACGATGGCCTGGTCAAGGAC
GGCATCATCCTCAACGACGAAACCGTCGAAGTACTCCAGAAAATGGCCGTTTCTCACGCC
GAAGCTGGCGCAGACTTCGTCTCCCCGAGCGACATGATGGACGGCCGCATCGGCGCCATC
CGCGAAGCACTCGACGAAACCGACCACTCCGACGTGGGCATTCTCTCCTACGCTGCCAAG
TACGCTTCGAGCTTCTACGGCCCGTTCCGTGACGCGCTGCACTCAGCACCGCAGTTCGGC
GACAAAAGCACCTACCAGATGAACCCGGCCAACACCGAAGAGGCGATGAAAGAGGTCGAA
CTCGACATCGTCGAAGGCGCTGACATCGTCATGGTCAAACCTGGCCTGGCCTACCTCGAC
ATCGTCTGGCGCACCAAGGAGCGCTTCGACGTGCCGGTCGCCATCTACCACGTTTCCGGC
GAATACGCCATGGTGAAAGCTGCCGCCGCCAAGGGCTGGATCGACGAAGATCGCGTCATG
ATGGAGTCGCTGCTCTGCATGAAGCGCGCAGGTGCTGACATCATCTTCACCTACTACGCC
AAAGAAGCCGCCAAAAAGCTGCGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ59334
UniProtKB Entry NameHEM2_CHLP8
GenBank Protein ID1033198
GenBank Gene IDU38348
General References
  1. Rhie G, Avissar YJ, Beale SI: Structure and expression of the Chlorobium vibrioforme hemB gene and characterization of its encoded enzyme, porphobilinogen synthase. J Biol Chem. 1996 Apr 5;271(14):8176-82. [Article]
  2. Coates L, Beaven G, Erskine PT, Beale SI, Avissar YJ, Gill R, Mohammed F, Wood SP, Shoolingin-Jordan P, Cooper JB: The X-ray structure of the plant like 5-aminolaevulinic acid dehydratase from Chlorobium vibrioforme complexed with the inhibitor laevulinic acid at 2.6 A resolution. J Mol Biol. 2004 Sep 10;342(2):563-70. [Article]
  3. Coates L, Beaven G, Erskine PT, Beale SI, Wood SP, Shoolingin-Jordan PM, Cooper JB: Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1594-8. Epub 2005 Nov 19. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB045604,7-Dioxosebacic AcidexperimentalunknownDetails