Delta-aminolevulinic acid dehydratase
Details
- Name
- Delta-aminolevulinic acid dehydratase
- Synonyms
- 4.2.1.24
- ALAD
- Porphobilinogen synthase
- Gene Name
- hemB
- Organism
- Chlorobaculum parvum (strain NCIB 8327)
- Amino acid sequence
>lcl|BSEQ0011428|Delta-aminolevulinic acid dehydratase MSQLDLLNIVHRPRRLRRTAALRNLVQENTLTVNDLVFPLFVMPGTNAVEEVSSMPGSFR FTIDRAVEECKELYDLGIQGIDLFGIPEQKTEDGSEAYNDNGILQQAIRAIKKAVPELCI MTDVALDPFTPFGHDGLVKDGIILNDETVEVLQKMAVSHAEAGADFVSPSDMMDGRIGAI REALDETDHSDVGILSYAAKYASSFYGPFRDALHSAPQFGDKSTYQMNPANTEEAMKEVE LDIVEGADIVMVKPGLAYLDIVWRTKERFDVPVAIYHVSGEYAMVKAAAAKGWIDEDRVM MESLLCMKRAGADIIFTYYAKEAAKKLR
- Number of residues
- 328
- Molecular Weight
- 36394.215
- Theoretical pI
- 4.53
- GO Classification
- Functionsmetal ion binding / porphobilinogen synthase activityProcessesprotoporphyrinogen IX biosynthetic process
- General Function
- Porphobilinogen synthase activity
- Specific Function
- Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.
- Pfam Domain Function
- ALAD (PF00490)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011429|Delta-aminolevulinic acid dehydratase (hemB) ATGAGCCAGCTCGACCTCCTCAATATTGTGCATCGCCCGAGAAGACTTCGCAGAACCGCA GCGCTCCGCAACCTTGTGCAGGAAAACACGCTGACGGTCAACGATCTTGTGTTCCCCCTG TTCGTCATGCCCGGCACCAACGCCGTTGAAGAGGTTTCATCCATGCCCGGCAGCTTCCGC TTCACCATCGACCGCGCTGTCGAAGAGTGCAAGGAGCTTTACGATCTCGGCATCCAGGGC ATCGATCTGTTCGGCATTCCGGAGCAGAAAACCGAAGACGGCAGCGAAGCCTACAACGAC AACGGCATTCTTCAGCAGGCCATCCGCGCCATCAAGAAAGCCGTGCCGGAGCTGTGCATC ATGACCGACGTTGCACTTGACCCGTTCACCCCATTCGGCCACGATGGCCTGGTCAAGGAC GGCATCATCCTCAACGACGAAACCGTCGAAGTACTCCAGAAAATGGCCGTTTCTCACGCC GAAGCTGGCGCAGACTTCGTCTCCCCGAGCGACATGATGGACGGCCGCATCGGCGCCATC CGCGAAGCACTCGACGAAACCGACCACTCCGACGTGGGCATTCTCTCCTACGCTGCCAAG TACGCTTCGAGCTTCTACGGCCCGTTCCGTGACGCGCTGCACTCAGCACCGCAGTTCGGC GACAAAAGCACCTACCAGATGAACCCGGCCAACACCGAAGAGGCGATGAAAGAGGTCGAA CTCGACATCGTCGAAGGCGCTGACATCGTCATGGTCAAACCTGGCCTGGCCTACCTCGAC ATCGTCTGGCGCACCAAGGAGCGCTTCGACGTGCCGGTCGCCATCTACCACGTTTCCGGC GAATACGCCATGGTGAAAGCTGCCGCCGCCAAGGGCTGGATCGACGAAGATCGCGTCATG ATGGAGTCGCTGCTCTGCATGAAGCGCGCAGGTGCTGACATCATCTTCACCTACTACGCC AAAGAAGCCGCCAAAAAGCTGCGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q59334 UniProtKB Entry Name HEM2_CHLP8 GenBank Protein ID 1033198 GenBank Gene ID U38348 - General References
- Rhie G, Avissar YJ, Beale SI: Structure and expression of the Chlorobium vibrioforme hemB gene and characterization of its encoded enzyme, porphobilinogen synthase. J Biol Chem. 1996 Apr 5;271(14):8176-82. [Article]
- Coates L, Beaven G, Erskine PT, Beale SI, Avissar YJ, Gill R, Mohammed F, Wood SP, Shoolingin-Jordan P, Cooper JB: The X-ray structure of the plant like 5-aminolaevulinic acid dehydratase from Chlorobium vibrioforme complexed with the inhibitor laevulinic acid at 2.6 A resolution. J Mol Biol. 2004 Sep 10;342(2):563-70. [Article]
- Coates L, Beaven G, Erskine PT, Beale SI, Wood SP, Shoolingin-Jordan PM, Cooper JB: Structure of Chlorobium vibrioforme 5-aminolaevulinic acid dehydratase complexed with a diacid inhibitor. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1594-8. Epub 2005 Nov 19. [Article]