Delta-aminolevulinic acid dehydratase

Details

Name
Delta-aminolevulinic acid dehydratase
Synonyms
  • 4.2.1.24
  • ALAD
  • Porphobilinogen synthase
Gene Name
hemB
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0010895|Delta-aminolevulinic acid dehydratase
MSFTPANRAYPYTRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGVNQRESIPSMPGV
ERLSIDQLLIEAEEWVALGIPALALFPVTPVEKKSLDAAEAYNPEGIAQRATRALRERFP
ELGIITDVALDPFTTHGQDGILDDDGYVLNDVSIDVLVRQALSHAEAGAQVVAPSDMMDG
RIGAIREALESAGHTNVRIMAYSAKYASAYYGPFRDAVGSASNLGKGNKATYQMDPANSD
EALHEVAADLAEGADMVMVKPGMPYLDIVRRVKDEFRAPTFVYQVSGEYAMHMGAIQNGW
LAESVILESLTAFKRAGADGILTYFAKQAAEQLRRGR
Number of residues
337
Molecular Weight
37036.6
Theoretical pI
4.83
GO Classification
Functions
porphobilinogen synthase activity / zinc ion binding
Processes
heme biosynthetic process / porphyrin-containing compound biosynthetic process / protoporphyrinogen IX biosynthetic process
Components
cytosol
General Function
Zinc ion binding
Specific Function
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0010896|Delta-aminolevulinic acid dehydratase (hemB)
GTGAGCTTCACTCCCGCCAATCGCGCCTATCCCTACACCCGCCTGCGGCGCAATCGCCGC
GATGACTTCTCCCGCCGCCTGGTCCGCGAGAATGTCCTCACCGTCGACGACCTGATCCTG
CCGGTGTTCGTCCTCGATGGGGTCAACCAGCGTGAAAGCATTCCGTCGATGCCCGGCGTC
GAGCGCCTGTCCATCGACCAGTTGCTGATCGAGGCGGAAGAGTGGGTGGCCCTGGGCATT
CCGGCGCTGGCGCTGTTCCCTGTGACCCCGGTGGAGAAGAAGTCCCTGGACGCCGCCGAG
GCATACAACCCGGAAGGCATCGCCCAGCGCGCCACCCGTGCCCTGCGCGAGCGCTTTCCG
GAGCTGGGCATCATCACCGACGTGGCGCTCGACCCGTTCACCACCCATGGCCAGGACGGC
ATCCTGGATGACGATGGCTACGTCCTCAACGACGTCAGCATCGACGTGCTGGTACGGCAG
GCGCTGTCCCACGCCGAGGCCGGCGCCCAGGTGGTAGCGCCCTCGGACATGATGGACGGT
CGCATCGGTGCGATCCGCGAGGCCCTGGAGTCTGCCGGCCACACCAATGTGCGGATCATG
GCCTACTCGGCCAAGTACGCCAGCGCCTACTACGGTCCGTTCCGCGATGCGGTCGGCTCG
GCTTCGAACCTCGGCAAGGGCAACAAGGCCACCTACCAGATGGATCCGGCGAACAGCGAC
GAGGCACTTCACGAAGTGGCCGCCGACCTGGCCGAAGGCGCCGACATGGTGATGGTCAAG
CCGGGCATGCCCTACCTCGACATCGTGCGTCGGGTGAAGGATGAATTCCGCGCCCCGACC
TTTGTCTACCAGGTCAGCGGCGAGTATGCGATGCACATGGGCGCCATCCAGAACGGCTGG
CTGGCCGAATCGGTGATCCTCGAATCCCTTACCGCCTTCAAACGTGCCGGCGCCGATGGC
ATTCTGACCTACTTCGCCAAGCAGGCCGCAGAACAATTAAGACGGGGGCGTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ59643
UniProtKB Entry NameHEM2_PSEAE
GenBank Protein ID1009431
GenBank Gene IDX91820
General References
  1. Frankenberg N, Kittel T, Hungerer C, Romling U, Jahn D: Cloning, mapping and functional characterization of the hemB gene of Pseudomonas aeruginosa, which encodes a magnesium-dependent 5-aminolevulinic acid dehydratase. Mol Gen Genet. 1998 Feb;257(4):485-9. [Article]
  2. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
  3. Frankenberg N, Erskine PT, Cooper JB, Shoolingin-Jordan PM, Jahn D, Heinz DW: High resolution crystal structure of a Mg2+-dependent porphobilinogen synthase. J Mol Biol. 1999 Jun 11;289(3):591-602. [Article]
  4. Frere F, Schubert WD, Stauffer F, Frankenberg N, Neier R, Jahn D, Heinz DW: Structure of porphobilinogen synthase from Pseudomonas aeruginosa in complex with 5-fluorolevulinic acid suggests a double Schiff base mechanism. J Mol Biol. 2002 Jul 5;320(2):237-47. [Article]
  5. Frere F, Nentwich M, Gacond S, Heinz DW, Neier R, Frankenberg-Dinkel N: Probing the active site of Pseudomonas aeruginosa porphobilinogen synthase using newly developed inhibitors. Biochemistry. 2006 Jul 11;45(27):8243-53. [Article]
  6. Heinemann IU, Schulz C, Schubert WD, Heinz DW, Wang YG, Kobayashi Y, Awa Y, Wachi M, Jahn D, Jahn M: Structure of the heme biosynthetic Pseudomonas aeruginosa porphobilinogen synthase in complex with the antibiotic alaremycin. Antimicrob Agents Chemother. 2010 Jan;54(1):267-72. doi: 10.1128/AAC.00553-09. Epub 2009 Oct 12. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01942Formic acidexperimental, investigationalunknownDetails
DB028285-Fluorolevulinic AcidexperimentalunknownDetails