P-type Ca2+-transporting ATPase
Details
- Name
- P-type Ca2+-transporting ATPase
- Synonyms
- P-type calcium transporting ATPase
- Sarcoplasmic and endoplasmic reticulum Ca-ATPase
- Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase
- Gene Name
- serca
- Organism
- Plasmodium falciparum
- Amino acid sequence
>lcl|BSEQ0051351|P-type Ca2+-transporting ATPase MEEVIKNAHTYDVEDVLKFLDVNKDNGLKNEELDDRRLKYGLNELEVEKKKSIFELILNQ FDDLLVKILLLAAFISFVLTLLDMKHKKIEICDFIEPLVIVLILILNAAVGVWQECNAEK SLEALKELQPTKAKVLRDGKWEIIDSKYLYVGDIIELSVGNKTPADARIIKIYSTSLKVE QSMLTGESCSVDKYAEKMEDSYKNCEIQLKKNILFSSTAIVCGRCIAVVINIGMKTEIGH IQHAVIESNSEDTQTPLQIKIDLFGQQLSKIIFVICVTVWIINFKHFSDPIHGSFLYGCL YYFKISVALAVAAIPEGLPAVITTCLALGTRRMVKKNAIVRKLQSVETLGCTTVICSDKT GTLTTNQMTTTVFHLFRESDSLTEYQLCQKGDTYYFYESSNLTNDIYAGESSFFNKLKDE GNVEALTDDGEEGSIDEADPYSDYFSSDSKKMKNDLNNNNNNNNNSSRSGAKRNIPLKEM KSNENTIISRGSKILEDKINKYCYSEYDYNFYMCLVNCNEANIFCNDNSQIVKKFGDSTE LALLHFVHNFDILPTFSKNNKMPAEYEKNTTPVQSSNKKDKSPRGINKFFSSKNDNSHIT STLNENDKNLKNANHSNYTTAQATTNGYEAIGENTFEHGTSFENCFHSKLGNKINTTSTH NNNNNNNNNSNSVPSECISSWRNECKQIKIIEFTRERKLMSVIVENKKKEIILYCKGAPE NIIKNCKYYLTKNDIRPLNETLKNEIHNKIQNMGKRALRTLSFAYKKLSSKDLNIKNTDD YYKLEQDLIYLGGLGIIDPPRKYVGRAIRLCHMAGIRVFMITGDNINTARAIAKEINILN KNEGDDEKDNYTNNKNTQICCYNGREFEDFSLEKQKHILKNTPRIVFCRTEPKHKKQIVK VLKDLGETVAMTGDGVNDAPALKSADIGIAMGINGTEVAKEASDIVLADDNFNTIVEAIK EGRCIYNNMKAFIRYLISSNIGEVASIFITALLGIPDSLAPVQLLWVNLVTDGLPATALG FNPPEHDVMKCKPRHKNDNLINGLTLLRYIIIGTYVGIATVSIFVYWFLFYPDSDMHTLI NFYQLSHYNQCKAWNNFRVNKVYDMSEDHCSYFSAGKIKASTLSLSVLVLIEMFNALNAL SEYNSLFEIPPWRNMYLVLATIGSLLLHVLILYIPPLARIFGVVPLSAYDWFLVFLWSFP VIILDEIIKFYAKRKLKEEQRTKKIKID
- Number of residues
- 1228
- Molecular Weight
- 139413.605
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / hydrolase activityComponentsintegral component of membrane
- General Function
- Not Available
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- 64-82 94-113 213-233 268-287 1046-1069 1155-1174 1194-1212
- Cellular Location
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q5R2K6 UniProtKB Entry Name Q5R2K6_PLAFA - General References
- Tanabe K, Sakihama N, Hattori T, Ranford-Cartwright L, Goldman I, Escalante AA, Lal AA: Genetic distance in housekeeping genes between Plasmodium falciparum and Plasmodium reichenowi and within P. falciparum. J Mol Evol. 2004 Nov;59(5):687-94. doi: 10.1007/s00239-004-2662-3. [Article]
- Tanabe K, Mita T, Jombart T, Eriksson A, Horibe S, Palacpac N, Ranford-Cartwright L, Sawai H, Sakihama N, Ohmae H, Nakamura M, Ferreira MU, Escalante AA, Prugnolle F, Bjorkman A, Farnert A, Kaneko A, Horii T, Manica A, Kishino H, Balloux F: Plasmodium falciparum accompanied the human expansion out of Africa. Curr Biol. 2010 Jul 27;20(14):1283-9. doi: 10.1016/j.cub.2010.05.053. Epub 2010 Jun 17. [Article]
- Tanabe K, Zakeri S, Palacpac NM, Afsharpad M, Randrianarivelojosia M, Kaneko A, Marma AS, Horii T, Mita T: Spontaneous mutations in the Plasmodium falciparum sarcoplasmic/ endoplasmic reticulum Ca2+-ATPase (PfATP6) gene among geographically widespread parasite populations unexposed to artemisinin-based combination therapies. Antimicrob Agents Chemother. 2011 Jan;55(1):94-100. doi: 10.1128/AAC.01156-10. Epub 2010 Oct 18. [Article]
- Miao M, Wang Z, Yang Z, Yuan L, Parker DM, Putaporntip C, Jongwutiwes S, Xangsayarath P, Pongvongsa T, Moji H, Dinh Tuong T, Abe T, Nakazawa S, Kyaw MP, Yan G, Sirichaisinthop J, Sattabongkot J, Mu J, Su XZ, Kaneko O, Cui L: Genetic diversity and lack of artemisinin selection signature on the Plasmodium falciparum ATP6 in the Greater Mekong Subregion. PLoS One. 2013;8(3):e59192. doi: 10.1371/journal.pone.0059192. Epub 2013 Mar 26. [Article]
- Yalcindag E, Rougeron V, Elguero E, Arnathau C, Durand P, Brisse S, Diancourt L, Aubouy A, Becquart P, D'Alessandro U, Fontenille D, Gamboa D, Maestre A, Menard D, Musset L, Noya O, Veron V, Wide A, Carme B, Legrand E, Chevillon C, Ayala FJ, Renaud F, Prugnolle F: Patterns of selection on Plasmodium falciparum erythrocyte-binding antigens after the colonization of the New World. Mol Ecol. 2014 Apr;23(8):1979-93. [Article]