Serine/threonine-protein kinase MRCK gamma
Details
- Name
- Serine/threonine-protein kinase MRCK gamma
- Synonyms
- 2.7.11.1
- CDC42-binding protein kinase gamma
- DMPK-like gamma
- DMPK2
- MRCK gamma
- MRCKG
- Myotonic dystrophy kinase-related CDC42-binding kinase gamma
- Myotonic dystrophy protein kinase-like alpha
- Myotonic dystrophy protein kinase-like gamma
- Gene Name
- CDC42BPG
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051720|Serine/threonine-protein kinase MRCK gamma MERRLRALEQLARGEAGGCPGLDGLLDLLLALHHELSSGPLRRERSVAQFLSWASPFVSK VKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREER DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMV LAIHSLHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISP EILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPD VPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPM DTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQ CLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGS PGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQT RALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPP EGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQ ESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTL PARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEA EKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGG EPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLML GLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPS GVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQ SRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYT LKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSP SAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVK RQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLAL GAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPM GWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRN QLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPP TNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGG DADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSPELESSP
- Number of residues
- 1551
- Molecular Weight
- 172457.57
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / magnesium ion binding / protein serine/threonine kinase activityProcessesactin cytoskeleton reorganization / intracellular signal transduction / protein phosphorylationComponentscell leading edge / cytosol / microtubule organizing center
- General Function
- May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity).
- Specific Function
- Atp binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051721|Serine/threonine-protein kinase MRCK gamma (CDC42BPG) ATGGAGCGGCGGCTGCGCGCGCTGGAGCAGCTGGCGCGGGGCGAGGCCGGCGGCTGCCCG GGGCTCGACGGCCTCCTAGATCTGCTGCTGGCGCTGCACCACGAGCTCAGCAGCGGCCCC CTACGGCGGGAGCGCAGCGTGGCGCAGTTCCTGAGCTGGGCCAGCCCCTTCGTATCAAAG GTGAAAGAACTGCGTCTGCAGAGAGATGACTTTGAGATCTTGAAGGTGATCGGCCGAGGA GCCTTTGGGGAGGTCACCGTGGTGAGGCAGAGGGACACTGGGCAGATTTTTGCCATGAAA ATGCTGCACAAGTGGGAGATGCTGAAGAGGGCTGAGACAGCCTGTTTCCGGGAGGAGCGG GATGTGCTCGTGAAAGGGGACAGCCGTTGGGTGACCACTCTGCACTATGCCTTCCAAGAC GAGGAGTACCTGTACCTTGTGATGGACTACTATGCTGGTGGGGACCTCCTGACGCTGCTG AGCCGCTTCGAGGACCGTCTCCCGCCCGAGCTGGCCCAGTTCTACCTGGCTGAGATGGTG CTGGCCATCCACTCGCTGCACCAGCTGGGTTATGTCCACAGGGATGTCAAGCCAGACAAC GTCCTGCTGGATGTGAACGGGCACATTCGCCTGGCTGACTTCGGCTCCTGCCTGCGTCTC AACACCAACGGCATGGTGGATTCATCAGTGGCAGTAGGGACGCCGGACTATATCTCCCCT GAGATCCTGCAGGCCATGGAGGAGGGCAAGGGCCACTACGGCCCACAGTGTGACTGGTGG TCGCTTGGAGTCTGCGCCTATGAGCTGCTCTTTGGGGAGACGCCCTTCTATGCTGAGTCC TTGGTGGAAACCTACGGCAAGATCATGAACCACGAGGACCACCTGCAGTTCCCCCCGGAC GTGCCTGACGTGCCAGCCAGCGCCCAAGACCTGATCCGCCAGCTGCTGTGTCGCCAGGAA GAGCGGCTAGGCCGTGGTGGGCTGGATGACTTCCGGAACCATCCTTTCTTCGAAGGCGTG GACTGGGAGCGGCTGGCGAGCAGCACGGCCCCCTATATTCCTGAGCTGCGGGGGCCCATG GACACCTCCAACTTTGATGTGGATGACGACACCCTCAACCATCCAGGGACCCTGCCACCG CCCTCCCACGGGGCCTTCTCCGGCCATCACCTGCCATTCGTGGGCTTCACCTACACCTCA GGCAGTCACAGTCCTGAGAGCAGCTCTGAGGCTTGGGCTGCCCTGGAGCGGAAGCTCCAG TGTCTGGAGCAGGAGAAGGTGGAGCTGAGCAGGAAGCACCAAGAGGCCCTGCACGCCCCC ACAGACCATCGGGAGCTGGAGCAGCTACGGAAGGAAGTGCAGACTCTGCGGGACAGGCTG CCAGAGATGCTGAGGGACAAGGCCTCATTGTCCCAGACGGATGGGCCCCCAGCTGGTAGC CCAGGTCAGGACAGTGACCTACGGCAGGAGCTTGACCGACTTCACCGGGAGCTGGCCGAG GGTCGGGCAGGGCTGCAGGCTCAGGAGCAGGAGCTCTGCAGGGCCCAGGGGCAGCAGGAG GAGCTGCTTCAGAGGCTACAGGAGGCCCAGGAGAGAGAGGCGGCCACAGCTAGCCAGACC CGGGCCCTGAGCTCCCAGCTGGAGGAAGCCCGGGCTGCCCAGAGGGAGCTGGAGGCCCAG GTGTCCTCCCTGAGCCGGCAGGTGACGCAGCTGCAGGGACAGTGGGAGCAACGCCTTGAG GAGTCGTCCCAGGCCAAGACCATCCACACAGCCTCTGAGACCAACGGGATGGGACCCCCT GAGGGTGGGCCTCAGGAGGCCCAACTGAGGAAGGAGGTGGCCGCCCTGCGAGAGCAGCTG GAGCAGGCCCACAGCCACAGGCCGAGTGGTAAGGAGGAGGCTCTGTGCCAGCTGCAGGAG GAAAACCGGAGGCTGAGCCGGGAGCAGGAGCGGCTAGAAGCAGAGCTGGCCCAGGAGCAG GAGAGCAAGCAGCGGCTGGAGGGTGAGCGGCGGGAGACGGAGAGCAACTGGGAGGCCCAG CTCGCCGACATCCTCAGCTGGGTGAATGATGAGAAGGTCTCAAGAGGCTACCTGCAGGCC CTGGCCACCAAGATGGCAGAGGAGCTGGAGTCCTTGAGGAACGTAGGCACCCAGACGCTC CCTGCCCGGCCACTGGACCACCAGTGGAAGGCGCGGCGACTGCAGAAGATGGAGGCCTCG GCCAGGCTGGAGCTGCAGTCAGCGCTGGAGGCCGAGATCCGCGCCAAGCAGGGCCTGCAG GAGCGGCTGACACAGGTGCAGGAGGCCCAGCTGCAGGCTGAGCGCCGTCTGCAGGAGGCC GAGAAGCAGAGCCAGGCCCTGCAACAGGAGCTCGCCATGCTGCGGGAGGAGCTGCGGGCC CGAGGGCCAGTGGACACCAAGCCCTCAAACTCCCTGATTCCCTTCCTGTCCTTCCGGAGC TCAGAGAAGGATTCTGCCAAGGACCCTGGCATCTCAGGAGAGGCCACAAGGCATGGAGGA GAGCCAGATCTGAGGCCGGAGGGCCGACGCAGCCTGCGCATGGGGGCTGTGTTCCCCAGA GCACCCACTGCCAACACAGCCTCTACAGAAGGTCTTCCTGCTAAGCCCGGCTCACACACG CTGCGCCCCCGGAGCTTCCCATCCCCGACCAAGTGTCTCCGCTGCACCTCGCTGATGCTG GGCCTGGGCCGCCAGGGCCTGGGTTGTGATGCCTGCGGCTACTTTTGTCACACAACCTGT GCCCCACAGGCCCCACCCTGCCCCGTGCCCCCTGACCTCCTCCGCACAGCCCTGGGAGTA CACCCCGAAACAGGCACAGGCACTGCCTATGAGGGCTTTCTGTCGGTGCCGCGGCCCTCA GGTGTCCGGCGGGGCTGGCAGCGCGTGTTTGCTGCCCTGAGTGACTCACGCCTGCTGCTG TTTGACGCCCCTGACCTGAGGCTCAGCCCGCCCAGTGGGGCCCTCCTGCAGGTCCTAGAT CTGAGGGACCCCCAGTTCTCGGCTACCCCTGTCCTGGCCTCTGATGTTATCCATGCCCAA TCCAGGGACCTGCCACGCATCTTTAGGGTGACAACCTCCCAGCTGGCAGTGCCGCCCACC ACGTGCACTGTGCTGCTGCTGGCAGAGAGCGAGGGGGAGCGGGAACGCTGGCTGCAGGTG CTGGGTGAGCTGCAGCGGCTGCTGCTGGACGCGCGGCCAAGACCCCGGCCCGTGTACACA CTCAAGGAGGCTTACGACAACGGGCTGCCGCTGCTGCCTCACACGCTCTGCGCTGCCATC CTCGACCAGGATCGACTTGCGCTTGGCACCGAGGAGGGGCTCTTTGTCATCCATCTGCGC AGCAACGACATCTTCCAGGTGGGGGAGTGCCGGCGCGTGCAGCAGCTGACCTTGAGCCCC AGTGCAGGCCTGCTGGTCGTGCTGTGTGGCCGCGGCCCCAGCGTGCGTCTCTTTGCCCTG GCGGAGCTGGAGAACATAGAGGTAGCAGGTGCCAAGATCCCCGAGTCTCGAGGCTGCCAG GTGCTGGCAGCTGGAAGCATCCTGCAGGCCCGCACCCCGGTGCTCTGTGTAGCCGTCAAG CGCCAGGTGCTCTGCTACCAGCTGGGCCCGGGCCCTGGGCCCTGGCAGCGCCGCATCCGT GAGCTGCAGGCACCTGCCACTGTGCAGAGCCTGGGGCTGCTGGGCGACCGGCTATGTGTG GGCGCCGCCGGTGGCTTTGCACTCTACCCGCTGCTCAACGAGGCTGCGCCGTTGGCGCTG GGGGCCGGTTTGGTGCCTGAGGAGCTGCCACCATCCCGCGGGGGCCTGGGTGAGGCACTG GGTGCCGTGGAGCTTAGCCTCAGCGAGTTCCTGCTACTCTTCACCACTGCTGGCATCTAC GTGGATGGCGCAGGCCGCAAGTCTCGTGGCCACGAGCTGTTGTGGCCAGCAGCGCCCATG GGCTGGGGGTATGCGGCCCCCTACCTGACAGTGTTCAGCGAGAACTCCATCGATGTGTTT GACGTGAGGAGGGCAGAATGGGTGCAGACCGTGCCGCTCAAGAAGGTGCGGCCCCTCAAT CCAGAGGGCTCCCTGTTCCTCTACGGCACCGAGAAGGTCCGCCTGACCTACCTCAGGAAC CAGCTGGCAGAGAAGGACGAGTTCGACATCCCGGACCTCACCGACAACAGCCGGCGCCAG CTGTTCCGCACCAAGAGCAAGCGCCGCTTCTTTTTCCGCGTGTCGGAGGAGCAGCAGAAG CAGCAGCGCAGGGAGATGCTGAAGGACCCTTTTGTGCGCTCCAAGCTCATCTCGCCGCCT ACCAACTTCAACCACCTAGTACACGTGGGCCCTGCCAACGGGCGGCCCGGCGCCAGGGAC AAGTCCCCGGCTCCCGAAGAGAAGGGCCGAGTTGCCCGCGGCTCCGGCCCACAGCGGCCC CACAGCTTCTCCGAGGCGTTGCGGCGCCCAGCCTCCATGGGCAGCGAAGGCCTCGGTGGA GACGCAGACCCCATGAAGAGGAAACCCTGGACATCCCTGTCCAGCGAGTCTGTGTCCTGC CCCCAGGGATCGCTGAGCCCTGCAACCTCCCTAATGCAGGTCTCAGAACGGCCCCGAAGC CTCCCCCTATCCCCTGAATTGGAGAGCTCTCCTTGA
- Chromosome Location
- 11
- Locus
- 11q13.1
- External Identifiers
Resource Link UniProtKB ID Q6DT37 UniProtKB Entry Name MRCKG_HUMAN HGNC ID HGNC:29829 - General References
- Ng Y, Tan I, Lim L, Leung T: Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. J Biol Chem. 2004 Aug 13;279(33):34156-64. doi: 10.1074/jbc.M405252200. Epub 2004 Jun 11. [Article]
- Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
- Kedra D, Seroussi E, Fransson I, Trifunovic J, Clark M, Lagercrantz J, Blennow E, Mehlin H, Dumanski J: The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet. 1997 Oct;100(5-6):611-9. [Article]
- Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]
- Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]