N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
Details
- Name
- N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
- Synonyms
- 3.1.4.54
- C7orf18
- N-acyl phosphatidylethanolamine phospholipase D
- Gene Name
- NAPEPLD
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051337|N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKG KDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGV REAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDA VLISHNHYDHLDYNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPG HDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGP FDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVK LNEALERYGLNAEDFFVLKHGESRYLNNDDENF
- Number of residues
- 393
- Molecular Weight
- 45595.15
- Theoretical pI
- Not Available
- GO Classification
- Functionsidentical protein binding / N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity / N-acylphosphatidylethanolamine-specific phospholipase D activity / zinc ion bindingProcessesaging / N-acylethanolamine metabolic process / negative regulation of eating behavior / phospholipid catabolic process / response to isolation stress / retinoid metabolic processComponentscytosol / extracellular exosome / photoreceptor outer segment membrane
- General Function
- Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).
- Specific Function
- Identical protein binding
- Pfam Domain Function
- Lactamase_B_2 (PF12706)
- Transmembrane Regions
- Not Available
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0051338|N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD) ATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCA GTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCT AGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGA AAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTT CTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGGAACTA GACAAAGAACTCCCAGTGCTTAAGCCATATTTTATCACTAACCCTGAAGAAGCTGGAGTG AGGGAAGCTGGCTTAAGAGTCACATGGCTGGGACATGCCACGGTAATGGTGGAAATGGAT GAGCTCATATTTCTCACGGATCCCATCTTTAGCTCTCGTGCTTCACCATCGCAGTACATG GGTCCAAAGCGATTTCGTCGTTCCCCGTGCACAATAAGTGAACTCCCTCCAATAGATGCG GTCCTTATCAGTCACAACCACTATGACCATCTGGACTACAATTCTGTCATTGCTTTGAAT GAGCGATTTGGTAATGAGTTGAGATGGTTTGTGCCTTTGGGTCTCCTTGACTGGATGCAA AAATGTGGCTGTGAGAATGTGATTGAGTTGGACTGGTGGGAGGAGAATTGTGTCCCCGGA CATGATAAGGTCACTTTTGTCTTTACACCTTCCCAGCACTGGTGTAAAAGGACTCTAATG GATGACAACAAGGTGCTATGGGGCAGCTGGTCTGTCTTGGGGCCTTGGAATCGATTTTTT TTCGCAGGAGATACTGGTTATTGCCCTGCTTTTGAAGAGATAGGAAAAAGATTTGGACCT TTTGACCTTGCAGCTATTCCCATCGGAGCTTATGAACCGAGGTGGTTTATGAAATACCAG CATGTAGACCCAGAAGAAGCTGTAAGGATTCACACTGATGTCCAAACAAAGAAATCTATG GCAATTCACTGGGGAACTTTTGCCTTAGCAAATGAGCATTACTTAGAGCCTCCAGTGAAG CTGAATGAAGCTCTAGAGAGATACGGACTTAACGCTGAAGATTTTTTTGTCTTGAAGCAT GGAGAATCAAGATACCTAAATAATGATGATGAAAACTTTTAA
- Chromosome Location
- 7
- Locus
- 7q22.1
- External Identifiers
Resource Link UniProtKB ID Q6IQ20 UniProtKB Entry Name NAPEP_HUMAN HGNC ID HGNC:21683 - General References
- Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N: Molecular characterization of a phospholipase D generating anandamide and its congeners. J Biol Chem. 2004 Feb 13;279(7):5298-305. doi: 10.1074/jbc.M306642200. Epub 2003 Nov 21. [Article]
- Curtiss NP, Bonifas JM, Lauchle JO, Balkman JD, Kratz CP, Emerling BM, Green ED, Le Beau MM, Shannon KM: Isolation and analysis of candidate myeloid tumor suppressor genes from a commonly deleted segment of 7q22. Genomics. 2005 May;85(5):600-7. doi: 10.1016/j.ygeno.2005.01.013. [Article]
- Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
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- Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N: Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. J Biol Chem. 2006 May 5;281(18):12325-35. doi: 10.1074/jbc.M512359200. Epub 2006 Mar 9. [Article]
- Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18. [Article]