Adhesion G-protein coupled receptor D1

Details

Name
Adhesion G-protein coupled receptor D1
Synonyms
  • G-protein coupled receptor 133
  • G-protein coupled receptor PGR25
  • GPR133
  • PGR25
Gene Name
ADGRD1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009258|Adhesion G-protein coupled receptor D1
MEKLLRLCCWYSWLLLFYYNFQVRGVYSRSQDHPGFQVLASASHYWPLENVDGIHELQDT
TGDIVEGKVNKGIYLKEEKGVTLLYYGRYNSSCISKPEQCGPEGVTFSFFWKTQGEQSRP
IPSAYGGQVISNGFKVCSSGGRGSVELYTRDNSMTWEASFSPPGPYWTHVLFTWKSKEGL
KVYVNGTLSTSDPSGKVSRDYGESNVNLVIGSEQDQAKCYENGAFDEFIIWERALTPDEI
AMYFTAAIGKHALLSSTLPSLFMTSTASPVMPTDAYHPIITNLTEERKTFQSPGVILSYL
QNVSLSLPSKSLSEQTALNLTKTFLKAVGEILLLPGWIALSEDSAVVLSLIDTIDTVMGH
VSSNLHGSTPQVTVEGSSAMAEFSVAKILPKTVNSSHYRFPAHGQSFIQIPHEAFHRHAW
STVVGLLYHSMHYYLNNIWPAHTKIAEAMHHQDCLLFATSHLISLEVSPPPTLSQNLSGS
PLITVHLKHRLTRKQHSEATNSSNRVFVYCAFLDFSSGEGVWSNHGCALTRGNLTYSVCR
CTHLTNFAILMQVVPLELARGHQVALSSISYVGCSLSVLCLVATLVTFAVLSSVSTIRNQ
RYHIHANLSFAVLVAQVLLLISFRLEPGTTPCQVMAVLLHYFFLSAFAWMLVEGLHLYSM
VIKVFGSEDSKHRYYYGMGWGFPLLICIISLSFAMDSYGTSNNCWLSLASGAIWAFVAPA
LFVIVVNIGILIAVTRVISQISADNYKIHGDPSAFKLTAKAVAVLLPILGTSWVFGVLAV
NGCAVVFQYMFATLNSLQGLFIFLFHCLLNSEVRAAFKHKTKVWSLTSSSARTSNAKPFH
SDLMNGTRPGMASTKLSPWDKSSHSAHRVDLSAV
Number of residues
874
Molecular Weight
96529.025
Theoretical pI
Not Available
GO Classification
Functions
G-protein coupled receptor activity
Processes
cell surface receptor signaling pathway / G-protein coupled receptor signaling pathway / positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
Components
integral component of membrane / plasma membrane
General Function
G-protein coupled receptor activity
Specific Function
Orphan receptor. Signals via G(s)-alpha family of G-proteins.
Pfam Domain Function
Transmembrane Regions
571-591 603-623 634-654 675-695 712-732 761-781 785-805
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0013702|Adhesion G-protein coupled receptor D1 (ADGRD1)
ATGGAAAAGCTGCTGCGGCTGTGCTGCTGGTACTCCTGGCTGCTGCTATTTTATTACAAC
TTTCAGGTGCGTGGCGTCTACTCCAGATCGCAGGACCATCCAGGATTTCAGGTGTTGGCG
TCTGCTTCCCATTACTGGCCACTGGAGAATGTGGATGGGATCCATGAACTTCAGGATACA
ACTGGAGATATTGTGGAAGGGAAGGTCAACAAAGGCATTTACCTGAAAGAGGAAAAGGGA
GTCACGCTTCTCTATTACGGCAGGTACAACAGCTCCTGCATCAGCAAGCCAGAGCAGTGT
GGCCCTGAAGGGGTCACGTTTTCTTTTTTCTGGAAGACACAAGGAGAACAGTCTAGACCA
ATCCCTTCTGCGTATGGGGGACAGGTCATCTCCAATGGGTTCAAAGTCTGCTCCAGCGGT
GGCAGAGGCTCTGTGGAGCTGTATACGCGGGACAATTCCATGACATGGGAGGCCTCCTTC
AGCCCCCCAGGCCCCTATTGGACTCATGTCCTATTTACATGGAAATCCAAGGAGGGCCTG
AAAGTCTACGTCAACGGGACCCTGAGCACCTCTGATCCGAGTGGAAAAGTGTCTCGTGAC
TATGGAGAGTCCAACGTCAACCTCGTGATAGGGTCTGAGCAGGACCAGGCCAAGTGTTAT
GAGAACGGTGCTTTCGATGAGTTCATCATCTGGGAGCGGGCTCTGACTCCGGATGAGATC
GCCATGTACTTCACTGCTGCCATTGGAAAGCATGCTTTATTGTCTTCAACGCTGCCAAGC
CTCTTCATGACATCCACAGCAAGCCCCGTGATGCCCACAGATGCCTACCATCCCATCATA
ACCAACCTGACAGAAGAGAGAAAAACCTTCCAAAGTCCCGGAGTGATACTGAGTTACCTC
CAAAATGTATCCCTCAGCTTACCCAGTAAGTCCCTCTCGGAGCAGACAGCCTTGAATCTC
ACCAAGACCTTCTTAAAAGCCGTGGGAGAGATCCTTCTACTGCCTGGTTGGATTGCTCTG
TCAGAGGACAGCGCCGTGGTACTGAGTCTCATCGACACTATTGACACCGTCATGGGCCAT
GTATCCTCCAACCTGCACGGCAGCACGCCCCAGGTCACCGTGGAGGGCTCCTCTGCCATG
GCAGAGTTTTCCGTGGCCAAAATCCTGCCCAAGACCGTGAATTCCTCCCATTACCGCTTC
CCGGCCCACGGGCAGAGCTTCATCCAGATCCCCCACGAGGCCTTCCACAGGCACGCCTGG
AGCACCGTCGTGGGTCTGCTGTACCACAGCATGCACTACTACCTGAACAACATCTGGCCC
GCCCACACCAAGATCGCGGAGGCCATGCATCACCAGGACTGCCTGCTGTTCGCCACCAGC
CACCTGATTTCCCTGGAGGTGTCCCCACCACCCACCCTGTCTCAGAACCTGTCGGGCTCT
CCACTCATTACGGTCCACCTCAAGCACAGATTGACACGTAAGCAGCACAGTGAGGCCACC
AACAGCAGCAACCGAGTCTTCGTGTACTGCGCCTTCCTGGACTTCAGCTCCGGAGAAGGG
GTCTGGTCGAACCACGGCTGTGCGCTCACGAGAGGAAACCTCACCTACTCCGTCTGCCGC
TGCACTCACCTCACCAACTTTGCCATCCTCATGCAGGTGGTCCCGCTGGAGCTTGCACGC
GGACACCAGGTGGCGCTGTCGTCTATCAGCTATGTGGGCTGCTCCCTCTCCGTGCTCTGC
CTGGTGGCCACGCTGGTCACCTTCGCCGTGCTGTCCTCCGTGAGCACCATCCGGAACCAG
CGCTACCACATCCACGCCAACCTGTCCTTCGCCGTGCTGGTGGCCCAGGTCCTGCTGCTC
ATTAGTTTCCGCCTCGAGCCGGGCACGACCCCCTGCCAAGTGATGGCCGTGCTCCTACAC
TACTTCTTCCTGAGTGCCTTCGCATGGATGCTGGTGGAGGGGCTGCACCTCTACAGCATG
GTGATCAAGGTCTTTGGGTCGGAGGACAGCAAGCACCGTTACTACTATGGGATGGGATGG
GGTTTTCCTCTTCTGATCTGCATCATTTCACTGTCATTTGCCATGGACAGTTACGGAACA
AGCAACAATTGCTGGCTGTCGTTGGCGAGTGGCGCCATCTGGGCCTTTGTAGCCCCTGCC
CTGTTTGTCATCGTGGTCAACATTGGCATCCTCATCGCTGTGACCAGAGTCATCTCACAG
ATCAGCGCCGACAACTACAAGATCCATGGAGACCCCAGTGCCTTCAAGTTGACAGCCAAG
GCAGTGGCCGTGCTGCTGCCCATCCTGGGTACCTCGTGGGTCTTTGGCGTGCTTGCTGTC
AACGGTTGTGCTGTGGTTTTCCAGTACATGTTTGCCACGCTCAACTCCCTGCAGGGACTG
TTCATATTCCTCTTTCATTGTCTCCTGAATTCAGAGGTGAGAGCCGCCTTCAAGCACAAA
ACCAAGGTCTGGTCGCTCACGAGCAGCTCTGCCCGCACCTCCAACGCGAAGCCCTTCCAC
TCGGACCTCATGAATGGGACCCGGCCAGGCATGGCCTCCACCAAGCTCAGCCCTTGGGAC
AAGAGCAGCCACTCTGCCCACCGCGTCGACCTGTCAGCCGTGTGA
Chromosome Location
12
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ6QNK2
UniProtKB Entry NameAGRD1_HUMAN
HGNC IDHGNC:19893
General References
  1. Bjarnadottir TK, Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB: The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. 2004 Jul;84(1):23-33. [Article]
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  6. Bohnekamp J, Schoneberg T: Cell adhesion receptor GPR133 couples to Gs protein. J Biol Chem. 2011 Dec 9;286(49):41912-6. doi: 10.1074/jbc.C111.265934. Epub 2011 Oct 24. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12637OnapristoneinvestigationalunknownDetails