Phosphopantetheine adenylyltransferase

Details

Name

Phosphopantetheine adenylyltransferase

Synonyms

• 2.7.7.3
• Dephospho-CoA pyrophosphorylase
• Pantetheine-phosphate adenylyltransferase
• PPAT

Gene Name

coaD

Organism

Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)

Amino acid sequence

>lcl|BSEQ0011400|Phosphopantetheine adenylyltransferase
MHVVYPGSFDPLTNGHLDVIQRASRLFEKVTVAVLENPSKRGQYLFSAEERLAIIREATA
HLANVEAATFSGLLVDFVRRVGAQAIVKGLRAVSDYEYELQMAHLNRQLYPGLETLFILA
ATRYSFVSSTMVKEIARYGGDVSKLVPPATLRALKAKLGQ

Number of residues

160

Molecular Weight

17707.325

Theoretical pI

9.81

GO Classification

Functions

ATP binding / pantetheine-phosphate adenylyltransferase activity

Processes

coenzyme A biosynthetic process

Components

cytoplasm

General Function

Pantetheine-phosphate adenylyltransferase activity

Specific Function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Pfam Domain Function

• CTP_transf_like (PF01467)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0011401|Phosphopantetheine adenylyltransferase (coaD)
ATGCACGTGGTCTACCCTGGGAGCTTTGACCCCCTGACCAACGGCCACCTGGACGTGATC
CAGCGGGCGAGCCGGCTCTTTGAGAAGGTGACCGTGGCCGTCCTGGAGAACCCGAGCAAG
CGGGGCCAGTACCTCTTCAGCGCCGAGGAGCGCCTGGCCATCATTCGGGAGGCCACGGCC
CACCTGGCCAACGTGGAGGCGGCCACCTTCTCCGGCCTCCTCGTGGACTTCGTGCGCCGG
GTGGGGGCCCAGGCCATCGTGAAGGGGCTTAGGGCGGTGTCCGACTACGAGTACGAGCTC
CAGATGGCCCACCTGAACCGCCAGCTCTACCCGGGCCTCGAGACCCTCTTCATCCTCGCC
GCCACCCGCTACTCCTTCGTCTCCAGCACCATGGTCAAGGAGATCGCCCGCTACGGGGGG
GATGTCTCCAAGCTCGTACCCCCGGCGACCCTGAGGGCCCTGAAGGCCAAGTTGGGCCAG
TAG

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q72K87
UniProtKB Entry Name	COAD_THET2
GenBank Protein ID	46196491
GenBank Gene ID	AE017221

General References

1. Henne A, Bruggemann H, Raasch C, Wiezer A, Hartsch T, Liesegang H, Johann A, Lienard T, Gohl O, Martinez-Arias R, Jacobi C, Starkuviene V, Schlenczeck S, Dencker S, Huber R, Klenk HP, Kramer W, Merkl R, Gottschalk G, Fritz HJ: The genome sequence of the extreme thermophile Thermus thermophilus. Nat Biotechnol. 2004 May;22(5):547-53. Epub 2004 Apr 4. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03912	D-pantetheine 4'-phosphate	experimental	unknown		Details