Organic solute transporter subunit beta
Details
- Name
- Organic solute transporter subunit beta
- Synonyms
- OST-beta
- OSTB
- Solute carrier family 51 subunit beta
- Gene Name
- SLC51B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0012548|Organic solute transporter subunit beta MEHSEGAPGDPAGTVVPQELLEEMLWFFRVEDASPWNHSILALAAVVVIISMVLLGRSIQ ASRKEKMQPPEKETPEVLHLDEAKDHNSLNNLRETLLSEKPNLAQVELELKERDVLSVFL PDVPETES
- Number of residues
- 128
- Molecular Weight
- 14346.195
- Theoretical pI
- 4.29
- GO Classification
- Functionsprotein heterodimerization activity / transporter activityProcessesbile acid and bile salt transport / positive regulation of protein exit from endoplasmic reticulum / positive regulation of protein glycosylation / positive regulation of protein targeting to membrane / regulation of protein stabilityComponentsintegral component of membrane / plasma membrane / protein complex
- General Function
- Transporter activity
- Specific Function
- Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
- Pfam Domain Function
- OSTbeta (PF15048)
- Transmembrane Regions
- 36-56
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0012549|Organic solute transporter subunit beta (SLC51B) ATGGAGCACAGTGAGGGGGCTCCCGGAGACCCAGCCGGTACTGTGGTACCCCAGGAGCTG CTGGAAGAGATGCTTTGGTTTTTTCGTGTGGAAGATGCATCTCCCTGGAATCATTCCATC CTTGCCCTGGCAGCTGTGGTGGTCATTATAAGCATGGTCCTCCTGGGAAGAAGCATCCAG GCAAGCAGAAAAGAAAAGATGCAGCCACCAGAAAAAGAAACTCCAGAAGTCCTGCATTTG GATGAGGCCAAGGATCACAACAGCCTAAACAACCTAAGAGAAACTTTGCTCTCAGAAAAG CCAAACTTGGCCCAGGTGGAACTTGAGTTAAAAGAGAGAGATGTGCTGTCAGTTTTCCTT CCGGATGTACCAGAAACTGAGAGCTAG
- Chromosome Location
- 15
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q86UW2 UniProtKB Entry Name OSTB_HUMAN GenBank Protein ID 30348897 GenBank Gene ID AY194242 HGNC ID HGNC:29956 - General References
- Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N: OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology. 2005 Dec;42(6):1270-9. [Article]
- Landrier JF, Eloranta JJ, Vavricka SR, Kullak-Ublick GA: The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes. Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G476-85. Epub 2005 Nov 3. [Article]
- Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA: FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. J Lipid Res. 2006 Jan;47(1):201-14. Epub 2005 Oct 26. [Article]