Spermidine synthase
Details
- Name
- Spermidine synthase
- Synonyms
- Not Available
- Gene Name
- Not Available
- Organism
- Plasmodium falciparum (isolate 3D7)
- Amino acid sequence
>lcl|BSEQ0051376|Spermidine synthase MDKLISNNKLKLSVVLLGGLCSLAYYHLKNKFHLSQFCFSKKWFSEFSIMWPGQAFSLKI KKILYETKSKYQNVLVFESTTYGKVLVLDGVIQLTEKDEFAYHEMMTHVPMTVSKEPKNV LVVGGGDGGIIRELCKYKSVENIDICEIDETVIEVSKIYFKNISCGYEDKRVNVFIEDAS KFLENVTNTYDVIIVDSSDPIGPAETLFNQNFYEKIYNALKPNGYCVAQCESLWIHVGTI KNMIGYAKKLFKKVEYANISIPTYPCGCIGILCCSKTDTGLTKPNKKLESKEFADLKYYN YENHSAAFKLPAFLLKEIENI
- Number of residues
- 321
- Molecular Weight
- 36595.23
- Theoretical pI
- Not Available
- GO Classification
- Functionsspermidine synthase activityProcessespolyamine biosynthetic process / spermidine biosynthetic processComponentscytosol
- General Function
- Not Available
- Specific Function
- Spermidine synthase activity
- Pfam Domain Function
- Spermine_synt_N (PF17284)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051377|Spermidine synthase ATGGATAAATTAATATCAAACAATAAATTAAAATTAAGTGTTGTATTATTAGGAGGATTA TGTTCTCTTGCTTATTATCATTTGAAAAATAAATTTCATCTTTCCCAGTTTTGTTTTTCA AAAAAATGGTTTAGTGAATTTTCCATAATGTGGCCTGGTCAGGCATTTAGTTTGAAGATA AAGAAAATATTATATGAAACAAAATCAAAATATCAAAATGTGTTGGTTTTTGAAAGTACC ACATATGGAAAGGTTTTAGTTCTAGACGGTGTAATACAACTAACCGAAAAAGATGAATTT GCTTATCATGAAATGATGACACATGTTCCTATGACTGTTTCTAAAGAACCAAAGAATGTT TTAGTTGTAGGTGGTGGTGATGGTGGTATCATAAGAGAATTATGTAAATATAAATCTGTT GAAAATATTGATATATGTGAAATCGATGAAACAGTTATTGAAGTATCGAAAATTTATTTT AAGAATATTAGTTGTGGTTATGAAGATAAAAGAGTTAATGTTTTTATTGAAGATGCAAGT AAGTTTTTAGAGAATGTTACAAATACTTATGATGTTATTATCGTAGATAGTTCAGATCCA ATAGGACCAGCAGAAACATTATTTAATCAAAATTTTTATGAAAAAATTTACAACGCCCTA AAGCCTAACGGTTACTGTGTCGCACAGTGCGAATCACTCTGGATACACGTGGGAACAATT AAAAATATGATTGGATATGCAAAAAAATTATTTAAGAAAGTGGAATATGCAAATATAAGT ATACCTACTTATCCATGTGGATGTATAGGTATATTATGCTGCTCAAAGACAGACACTGGA TTAACAAAACCAAATAAAAAATTAGAATCCAAAGAATTTGCTGACTTAAAATATTATAAT TATGAAAACCACTCAGCGGCTTTTAAATTACCAGCATTTCTTTTAAAAGAAATAGAAAAC ATATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8II73 UniProtKB Entry Name Q8II73_PLAF7 - General References
- Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
- Dufe VT, Qiu W, Muller IB, Hui R, Walter RD, Al-Karadaghi S: Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. J Mol Biol. 2007 Oct 12;373(1):167-77. doi: 10.1016/j.jmb.2007.07.053. Epub 2007 Aug 2. [Article]
- Vedadi M, Lew J, Artz J, Amani M, Zhao Y, Dong A, Wasney GA, Gao M, Hills T, Brokx S, Qiu W, Sharma S, Diassiti A, Alam Z, Melone M, Mulichak A, Wernimont A, Bray J, Loppnau P, Plotnikova O, Newberry K, Sundararajan E, Houston S, Walker J, Tempel W, Bochkarev A, Kozieradzki I, Edwards A, Arrowsmith C, Roos D, Kain K, Hui R: Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol. 2007 Jan;151(1):100-10. doi: 10.1016/j.molbiopara.2006.10.011. Epub 2006 Nov 13. [Article]
- Sprenger J, Svensson B, Halander J, Carey J, Persson L, Al-Karadaghi S: Three-dimensional structures of Plasmodium falciparum spermidine synthase with bound inhibitors suggest new strategies for drug design. Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):484-93. doi: 10.1107/S1399004714027011. Epub 2015 Feb 26. [Article]
- Burger PB, Williams M, Sprenger J, Reeksting SB, Botha M, Muller IB, Joubert F, Birkholtz LM, Louw AI: A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail. Malar J. 2015 Feb 5;14:54. doi: 10.1186/s12936-015-0572-z. [Article]