Choline transporter-like protein 2

Details

Name
Choline transporter-like protein 2
Synonyms
  • CTL2
  • Solute carrier family 44 member 2
Gene Name
SLC44A2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037173|Choline transporter-like protein 2
MGDERPHYYGKHGTPQKYDPTFKGPIYNRGCTDIICCVFLLLAIVGYVAVGIIAWTHGDP
RKVIYPTDSRGEFCGQKGTKNENKPYLFYFNIVKCASPLVLLEFQCPTPQICVEKCPDRY
LTYLNARSSRDFEYYKQFCVPGFKNNKGVAEVLQDGDCPAVLIPSKPLARRCFPAIHAYK
GVLMVGNETTYEDGHGSRKNITDLVEGAKKANGVLEARQLAMRIFEDYTVSWYWIIIGLV
IAMAMSLLFIILLRFLAGIMVWVMIIMVILVLGYGIFHCYMEYSRLRGEAGSDVSLVDLG
FQTDFRVYLHLRQTWLAFMIILSILEVIIILLLIFLRKRILIAIALIKEASRAVGYVMCS
LLYPLVTFFLLCLCIAYWASTAVFLSTSNEAVYKIFDDSPCPFTAKTCNPETFPSSNESR
QCPNARCQFAFYGGESGYHRALLGLQIFNAFMFFWLANFVLALGQVTLAGAFASYYWALR
KPDDLPAFPLFSAFGRALRYHTGSLAFGALILAIVQIIRVILEYLDQRLKAAENKFAKCL
MTCLKCCFWCLEKFIKFLNRNAYIMIAIYGTNFCTSARNAFFLLMRNIIRVAVLDKVTDF
LFLLGKLLIVGSVGILAFFFFTHRIRIVQDTAPPLNYYWVPILTVIVGSYLIAHGFFSVY
GMCVDTLFLCFLEDLERNDGSAERPYFMSSTLKKLLNKTNKKAAES
Number of residues
706
Molecular Weight
80122.695
Theoretical pI
8.71
GO Classification
Functions
choline transmembrane transporter activity / signal transducer activity
Processes
choline transport / glycerophospholipid biosynthetic process / phosphatidylcholine biosynthetic process / phospholipid metabolic process / positive regulation of I-kappaB kinase/NF-kappaB signaling / signal transduction / small molecule metabolic process / transmembrane transport
Components
extracellular exosome / integral component of membrane / lysosomal membrane / plasma membrane
General Function
Signal transducer activity
Specific Function
Isoform 1, but not isoform 3, exhibits some choline transporter activity.
Pfam Domain Function
Transmembrane Regions
34-54 233-253 257-277 316-336 365-385 458-480 505-525 564-584 600-620 639-659
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0011577|Choline transporter-like protein 2 (SLC44A2)
ATGGAGGACGAGCGGAAAAACGGAGCCTACGGAACGCCACAGAAGTATGATCCCACTTTC
AAAGGACCCATTTACAATAGGGGCTGCACGGATATCATATGCTGTGTGTTCCTGCTCCTG
GCCATTGTGGGCTACGTGGCTGTAGGCATCATAGCCTGGACTCATGGAGACCCTCGAAAG
GTGATCTACCCCACTGACAGCCGGGGCGAGTTCTGCGGGCAGAAGGGCACAAAAAACGAG
AACAAACCCTATCTGTTTTATTTCAACATTGTGAAATGTGCCAGCCCCCTGGTTCTGCTG
GAATTCCAATGTCCCACTCCCCAGATCTGCGTGGAAAAATGCCCCGACCGCTACCTCACG
TACCTGAATGCTCGCAGCTCCCGGGACTTTGAGTACTATAAGCAGTTCTGTGTTCCTGGC
TTCAAGAACAATAAAGGAGTGGCTGAGGTGCTTCAAGATGGTGACTGCCCTGCTGTCCTC
ATCCCCAGCAAACCCTTGGCCCGGAGATGCTTCCCCGCTATCCACGCCTACAAGGGTGTC
CTGATGGTGGGCAATGAGACGACCTATGAGGATGGGCATGGCTCCCGGAAAAACATCACA
GACCTGGTGGAGGGCGCCAAGAAAGCCAATGGAGTCCTAGAGGCGCGGCAACTCGCCATG
CGCATATTTGAAGATTACACCGTCTCTTGGTACTGGATTATCATAGGCCTGGTCATTGCC
ATGGCGATGAGCCTCCTGTTCATCATCCTGCTTCGCTTCCTGGCTGGTATTATGGTCTGG
GTGATGATCATCATGGTGATTCTGGTGCTGGGCTACGGAATATTTCACTGCTACATGGAG
TACTCCCGACTGCGTGGTGAGGCCGGCTCTGATGTCTCTTTGGTGGACCTCGGCTTTCAG
ACGGATTTCCGGGTGTACCTGCACTTACGGCAGACCTGGTTGGCCTTTATGATCATTCTG
AGTATCCTTGAAGTCATTATCATCTTGCTGCTCATCTTTCTCCGGAAGAGAATTCTCATC
GCGATTGCACTCATCAAAGAAGCCAGCAGGGCTGTGGGATACGTCATGTGCTCCTTGCTC
TACCCACTGGTCACCTTCTTCTTGCTGTGCCTCTGCATCGCCTACTGGGCCAGCACTGCT
GTCTTCCTGTCCACTTCCAACGAAGCGGTCTATAAGATCTTTGATGACAGCCCCTGCCCA
TTTACTGCGAAAACCTGCAACCCAGAGACCTTCCCCTCCTCCAATGAGTCCCGCCAATGC
CCCAATGCCCGTTGCCAGTTCGCCTTCTACGGTGGTGAGTCGGGCTACCACCGGGCCCTG
CTGGGCCTGCAGATCTTCAATGCCTTCATGTTCTTCTGGTTGGCCAACTTCGTGCTGGCG
CTGGGCCAGGTCACGCTGGCCGGGGCCTTTGCCTCCTACTACTGGGCCCTGCGCAAGCCG
GACGACCTGCCGGCCTTCCCGCTCTTCTCTGCCTTTGGCCGGGCGCTCAGGTACCACACA
GGCTCCCTGGCCTTTGGCGCGCTCATCCTGGCCATTGTGCAGATCATCCGTGTGATACTC
GAGTACCTGGATCAGCGGCTGAAAGCTGCAGAGAACAAGTTTGCCAAGTGCCTCATGACC
TGTCTCAAATGCTGCTTCTGGTGCCTGGAGAAGTTCATCAAATTCCTTAATAGGAATGCC
TACATCATGATTGCCATCTACGGCACCAATTTCTGCACCTCGGCCAGGAATGCCTTCTTC
CTGCTCATGAGAAACATCATCAGAGTGGCTGTCCTGGATAAAGTTACTGACTTCCTCTTC
CTGTTGGGCAAACTTCTGATCGTTGGTAGTGTGGGGATCCTGGCTTTCTTCTTCTTCACC
CACCGTATCAGGATCGTGCAGGATACAGCACCACCCCTCAATTATTACTGGGTTCCTATA
CTGACGGTGATCGTTGGCTCCTACTTGATTGCACACGGTTTCTTCAGCGTCTATGGCATG
TGTGTGGACACGCTGTTCCTCTGCTTCTTGGAGGACCTGGAGAGGAATGACGGCTCGGCC
GAGAGGCCTTACTTCATGTCTTCCACCCTCAAGAAACTCTTGAACAAGACCAACAAGAAG
GCAGCGGAGTCCTGA
Chromosome Location
19
Locus
19p13.1
External Identifiers
ResourceLink
UniProtKB IDQ8IWA5
UniProtKB Entry NameCTL2_HUMAN
GenBank Protein ID6996444
GenBank Gene IDAJ245621
GenAtlas IDSLC44A2
HGNC IDHGNC:17292
General References
  1. O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM: An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1835-40. [Article]
  2. Nair TS, Kozma KE, Hoefling NL, Kommareddi PK, Ueda Y, Gong TW, Lomax MI, Lansford CD, Telian SA, Satar B, Arts HA, El-Kashlan HK, Berryhill WE, Raphael Y, Carey TE: Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss. J Neurosci. 2004 Feb 18;24(7):1772-9. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  7. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005;12(2):117-26. [Article]
  8. Kommareddi PK, Nair TS, Raphael Y, Telian SA, Kim AH, Arts HA, El-Kashlan HK, Carey TE: Cochlin isoforms and their interaction with CTL2 (SLC44A2) in the inner ear. J Assoc Res Otolaryngol. 2007 Dec;8(4):435-46. Epub 2007 Oct 10. [Article]
  9. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
  10. Wollscheid B, Bausch-Fluck D, Henderson C, O'Brien R, Bibel M, Schiess R, Aebersold R, Watts JD: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. Nat Biotechnol. 2009 Apr;27(4):378-86. doi: 10.1038/nbt.1532. Epub 2009 Apr 6. [Article]
  11. Kommareddi PK, Nair TS, Thang LV, Galano MM, Babu E, Ganapathy V, Kanazawa T, McHugh JB, Carey TE: Isoforms, expression, glycosylation, and tissue distribution of CTL2/SLC44A2. Protein J. 2010 Aug;29(6):417-26. doi: 10.1007/s10930-010-9268-y. [Article]
  12. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00122Cholineapproved, nutraceuticalunknownsubstrateDetails