Pulmonary surfactant-associated protein A1
Details
- Name
- Pulmonary surfactant-associated protein A1
- Synonyms
- 35 kDa pulmonary surfactant-associated protein
- Alveolar proteinosis protein
- COLEC4
- Collectin-4
- PSAP
- PSP-A
- SFTP1
- SFTPA
- SFTPA1B
- Gene Name
- SFTPA1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009402|Pulmonary surfactant-associated protein A1 MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPM GPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQ TRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKK YNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLY SRLTICEF
- Number of residues
- 248
- Molecular Weight
- 26242.275
- Theoretical pI
- Not Available
- GO Classification
- Functionscarbohydrate binding / lipid transporter activityProcessescellular protein metabolic process / lipid transport / respiratory gaseous exchangeComponentsclathrin-coated endocytic vesicle / collagen trimer / endoplasmic reticulum membrane / extracellular region / extracellular space / lamellar body / proteinaceous extracellular matrix
- General Function
- Lipid transporter activity
- Specific Function
- In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
- Pfam Domain Function
- Lectin_C (PF00059)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017450|Pulmonary surfactant-associated protein A1 (SFTPA1) ATGAGGCCATGCCAGGTGCCAGGAGCAGCGACTGGACCCAGAGCCATGTGGCTGTGCCCT CTGGCCCTCAACCTCATCTTGATGGCAGCCTCTGGTGCTGTGTGCGAAGTGAAGGACGTT TGTGTTGGAAGCCCTGGTATCCCCGGCACTCCTGGATCCCACGGCCTGCCAGGCAGGGAC GGGAGAGATGGTCTCAAAGGAGACCCTGGCCCTCCAGGCCCCATGGGTCCACCTGGAGAA ATGCCATGTCCTCCTGGAAATGATGGGCTGCCTGGAGCCCCTGGTATCCCTGGAGAGTGT GGAGAGAAGGGGGAGCCTGGCGAGAGGGGCCCTCCAGGGCTTCCAGCTCATCTAGATGAG GAGCTCCAAGCCACACTCCACGACTTTAGACATCAAATCCTGCAGACAAGGGGAGCCCTC AGTCTGCAGGGCTCCATAATGACAGTAGGAGAGAAGGTCTTCTCCAGCAATGGGCAGTCC ATCACTTTTGATGCCATTCAGGAGGCATGTGCCAGAGCAGGCGGCCGCATTGCTGTCCCA AGGAATCCAGAGGAAAATGAGGCCATTGCAAGCTTCGTGAAGAAGTACAACACATATGCC TATGTAGGCCTGACTGAGGGTCCCAGCCCTGGAGACTTCCGCTACTCAGACGGGACCCCT GTAAACTACACCAACTGGTACCGAGGGGAGCCCGCAGGTCGGGGAAAAGAGCAGTGTGTG GAGATGTACACAGATGGGCAGTGGAATGACAGGAACTGCCTGTACTCCCGACTGACCATC TGTGAGTTCTGA
- Chromosome Location
- 10
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8IWL2 UniProtKB Entry Name SFTA1_HUMAN HGNC ID HGNC:10798 - General References
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