Monocarboxylate transporter 10
Details
- Name
- Monocarboxylate transporter 10
- Synonyms
- Aromatic amino acid transporter 1
- MCT 10
- MCT10
- Solute carrier family 16 member 10
- T-type amino acid transporter 1
- TAT1
- Gene Name
- SLC16A10
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007022|Monocarboxylate transporter 10 MVLSQEEPDSARGTSEAQPLGPAPTGAAPPPGPGPSDSPEAAVEKVEVELAGPATAEPHE PPEPPEGGWGWLVMLAAMWCNGSVFGIQNACGVLFVSMLETFGSKDDDKMVFKTAWVGSL SMGMIFFCCPIVSVFTDLFGCRKTAVVGAAVGFVGLMSSSFVSSIEPLYLTYGIIFACGC SFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLRVLIDSVGLFYTLRVLCIF MFVLFLAGFTYRPLATSTKDKESGGSGSSLFSRKKFSPPKKIFNFAIFKVTAYAVWAVGI PLALFGYFVPYVHLMKHVNERFQDEKNKEVVLMCIGVTSGVGRLLFGRIADYVPGVKKVY LQVLSFFFIGLMSMMIPLCSIFGALIAVCLIMGLFDGCFISIMAPIAFELVGAQDVSQAI GFLLGFMSIPMTVGPPIAGLLRDKLGSYDVAFYLAGVPPLIGGAVLCFIPWIHSKKQREI SKTTGKEKMEKMLENQNSLLSSSSGMFKKESDSII
- Number of residues
- 515
- Molecular Weight
- 55492.07
- Theoretical pI
- 7.77
- GO Classification
- Functionsaromatic amino acid transmembrane transporter activity / thyroid hormone transmembrane transporter activity / transporter activityProcessesamino acid transport / aromatic amino acid transport / ion transmembrane transport / ion transport / transmembrane transportComponentsbasolateral plasma membrane / integral component of membrane / integral component of plasma membrane / plasma membrane
- General Function
- Transporter activity
- Specific Function
- Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells (By similarity).
- Pfam Domain Function
- MFS_1 (PF07690)
- Transmembrane Regions
- 67-87 115-135 145-165 172-192 201-221 229-249 292-312 330-350 352-372 397-417 420-440 452-472
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020707|Monocarboxylate transporter 10 (SLC16A10) ATGGTGCTCTCCCAGGAGGAGCCGGACTCCGCGCGGGGCACGAGCGAGGCGCAGCCGCTC GGCCCCGCGCCCACGGGGGCCGCTCCGCCGCCCGGCCCGGGACCCTCGGACAGCCCCGAG GCGGCTGTCGAGAAGGTGGAGGTGGAGCTGGCGGGGCCGGCGACCGCGGAGCCCCATGAG CCCCCCGAACCCCCCGAGGGCGGCTGGGGCTGGCTGGTGATGCTGGCGGCCATGTGGTGC AACGGGTCGGTGTTCGGCATCCAGAACGCTTGCGGGGTGCTCTTCGTGTCCATGCTGGAA ACCTTCGGCTCCAAAGACGATGACAAGATGGTCTTTAAGACAGCATGGGTAGGTTCTCTC TCCATGGGGATGATTTTCTTTTGCTGCCCAATAGTCAGCGTCTTCACAGACCTATTTGGT TGTCGGAAAACAGCTGTCGTGGGTGCTGCTGTTGGATTTGTTGGGCTCATGTCCAGTTCT TTTGTAAGTTCCATCGAGCCTCTGTACCTTACCTATGGAATCATATTTGCCTGCGGCTGC TCCTTTGCATACCAGCCTTCATTGGTCATTTTGGGACACTATTTCAAGAAGCGCCTTGGA CTGGTGAATGGCATTGTCACTGCTGGCAGCAGTGTCTTCACAATCCTGCTGCCTTTGCTC TTAAGGGTTCTGATTGACAGCGTGGGCCTCTTTTACACATTGAGGGTGCTCTGCATCTTC ATGTTTGTTCTCTTTCTGGCTGGCTTTACTTACCGACCTCTTGCTACCAGTACCAAAGAT AAAGAGAGTGGAGGTAGCGGATCCTCCCTCTTTTCCAGGAAAAAGTTCAGTCCTCCAAAA AAAATTTTCAATTTTGCCATCTTCAAGGTGACAGCTTATGCAGTGTGGGCAGTTGGAATA CCACTTGCACTTTTTGGATACTTTGTGCCTTATGTTCACTTGATGAAACATGTAAATGAA AGATTTCAAGATGAAAAAAATAAAGAGGTTGTTCTCATGTGCATTGGCGTCACTTCAGGA GTTGGACGACTGCTCTTTGGCCGGATTGCAGATTATGTGCCTGGTGTGAAGAAGGTTTAT CTACAGGTACTCTCCTTTTTCTTCATTGGTCTGATGTCCATGATGATTCCTCTGTGTAGC ATCTTTGGGGCCCTCATTGCTGTGTGCCTCATCATGGGTCTCTTCGATGGATGCTTCATT TCCATTATGGCTCCCATAGCCTTTGAGTTAGTTGGTGCCCAGGATGTCTCCCAAGCAATT GGATTTCTGCTCGGATTCATGTCTATACCCATGACTGTTGGCCCACCCATTGCAGGGTTA CTTCGTGACAAACTGGGCTCCTATGATGTGGCATTCTACCTCGCTGGAGTCCCTCCCCTT ATTGGAGGTGCTGTGCTTTGTTTTATCCCGTGGATCCATAGTAAGAAGCAAAGAGAGATC AGTAAAACCACTGGAAAAGAAAAGATGGAGAAAATGTTGGAAAACCAGAACTCTCTGCTG TCAAGTTCATCTGGAATGTTCAAGAAAGAATCTGACTCTATTATTTAA
- Chromosome Location
- 6
- Locus
- 6q21-q22
- External Identifiers
Resource Link UniProtKB ID Q8TF71 UniProtKB Entry Name MOT10_HUMAN GenBank Protein ID 18640047 GenBank Gene ID AB057445 HGNC ID HGNC:17027 - General References
- Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00135 Tyrosine approved, investigational, nutraceutical unknown inhibitor Details DB00120 Phenylalanine approved, investigational, nutraceutical unknown inhibitor Details DB00150 Tryptophan approved, nutraceutical, withdrawn unknown inhibitor Details DB00149 Leucine investigational, nutraceutical unknown inhibitor Details DB00279 Liothyronine approved, vet_approved unknown inhibitor Details DB06262 Droxidopa approved, investigational unknown inhibitor Details DB01235 Levodopa approved unknown inhibitor Details DB00119 Pyruvic acid approved, investigational, nutraceutical unknown substrateinhibitor Details DB04398 Lactic acid approved, vet_approved unknown substrateinhibitor Details DB03225 D-Tryptophan experimental unknown inhibitor Details DB03839 D-Tyrosine experimental unknown inhibitor Details DB02556 D-Phenylalanine experimental unknown substrateinhibitor Details DB01746 D-Leucine experimental unknown inhibitor Details DB03929 D-Serine approved, experimental unknown inhibitor Details DB01786 D-Alanine experimental unknown inhibitor Details DB00138 Cystine approved, nutraceutical unknown inhibitor Details DB00172 Proline nutraceutical unknown inhibitor Details DB00125 Arginine investigational, nutraceutical unknown inhibitor Details DB00123 Lysine approved, nutraceutical unknown substrateinhibitor Details DB00142 Glutamic acid approved, nutraceutical unknown substrateinhibitor Details DB00128 Aspartic acid approved, nutraceutical unknown inhibitor Details DB00117 Histidine investigational, nutraceutical unknown substrateinhibitor Details DB00161 Valine approved, nutraceutical unknown inhibitor Details DB00167 Isoleucine investigational, nutraceutical unknown inhibitor Details DB00134 Methionine approved, nutraceutical unknown inhibitor Details DB00130 L-Glutamine approved, investigational, nutraceutical unknown inhibitor Details DB00174 Asparagine approved, investigational, nutraceutical unknown inhibitor Details DB00151 Cysteine approved, nutraceutical unknown inhibitor Details DB00156 Threonine approved, nutraceutical unknown inhibitor Details DB00133 Serine investigational, nutraceutical unknown inhibitor Details DB00160 Alanine nutraceutical unknown inhibitor Details DB00145 Glycine approved, nutraceutical, vet_approved unknown substrateinhibitor Details DB03107 beta-Alanine experimental unknown substrate Details DB02952 2-aminoisobutyric acid experimental unknown substrate Details DB01583 Liotrix approved unknown inhibitor Details