Acetyl-coenzyme A synthetase
Details
- Name
- Acetyl-coenzyme A synthetase
- Synonyms
- 6.2.1.1
- AcCoA synthetase
- Acetate--CoA ligase
- Acyl-activating enzyme
- Gene Name
- acs
- Organism
- Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
- Amino acid sequence
>lcl|BSEQ0011376|Acetyl-coenzyme A synthetase MSQTHKHAIPANIADRCLINPEQYETKYKQSINDPDTFWGEQGKILDWITPYQKVKNTSF APGNVSIKWYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDTSQSKHISYRELHRDVCRF ANTLLDLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSSS RLVITADEGVRAGRSIPLKKNVDDALKNPNVTSVEHVIVLKRTGSDIDWQEGRDLWWRDL IEKASPEHQPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDI YWCTADVGWVTGHSYLLYGPLACGATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTA IRALMAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGG FMITPLPGAIELKAGSATRPFFGVQPALVDNEGHPQEGATEGNLVITDSWPGQARTLFGD HERFEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHP KIAEAAVVGIPHAIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKEIGPLATPDVLHWTD SLPKTRSGKIMRRILRKIAAGDTSNLGDTSTLADPGVVEKLLEEKQAIAMPS
- Number of residues
- 652
- Molecular Weight
- 72152.085
- Theoretical pI
- 5.71
- GO Classification
- Functionsacetate-CoA ligase activity / AMP binding / ATP binding / metal ion bindingProcessesacetyl-CoA biosynthetic process from acetate / chemotaxis
- General Function
- Metal ion binding
- Specific Function
- Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011377|Acetyl-coenzyme A synthetase (acs) ATGAGCCAAACACATAAACACGCCATTCCCGCCAACATTGCGGATCGTTGCCTGATAAAT CCAGAGCAGTATGAGACTAAATATAAACAGTCTATTAACGACCCCGATACGTTTTGGGGC GAACAGGGAAAAATTCTCGATTGGATCACGCCGTACCAAAAAGTGAAAAACACCTCCTTT GCGCCAGGCAATGTGTCGATTAAATGGTACGAGGACGGCACGCTGAATCTGGCGGCGAAC TGTCTTGACCGCCATTTGCAGGAAAATGGCGATCGCACCGCCATTATCTGGGAAGGCGAT GACACGTCGCAGAGTAAACATATCTCTTATCGCGAACTGCATCGCGATGTCTGCCGTTTC GCGAATACGCTGCTGGATCTGGGCATTAAAAAAGGCGATGTGGTAGCGATTTATATGCCG ATGGTGCCGGAAGCGGCGGTGGCAATGTTGGCCTGCGCCCGCATCGGTGCGGTGCATTCG GTGATCTTCGGGGGCTTCTCGCCGGAAGCCGTCGCCGGACGCATTATCGACTCCAGCTCG CGGCTGGTGATCACCGCTGACGAAGGTGTACGTGCCGGACGCAGTATCCCGCTGAAAAAG AATGTCGATGACGCGCTGAAAAACCCGAATGTCACTAGCGTTGAGCATGTGATCGTCCTG AAGCGCACCGGCAGCGACATTGACTGGCAAGAAGGCCGCGACCTGTGGTGGCGCGATTTG ATTGAAAAAGCCAGCCCTGAGCACCAGCCTGAAGCGATGAATGCCGAAGATCCGCTGTTT ATCCTTTATACCTCCGGCTCCACCGGCAAGCCGAAAGGCGTGCTGCACACCACCGGCGGC TATCTGGTCTACGCCGCGACCACCTTTAAGTATGTCTTTGATTATCACCCTGGCGATATT TACTGGTGTACCGCCGATGTGGGTTGGGTGACGGGGCACAGCTATCTGTTGTATGGCCCG CTGGCCTGCGGCGCGACCACCTTAATGTTTGAAGGCGTGCCGAATTGGCCAACGCCCGCT CGCATGTGCCAGGTGGTCGACAAACACCAGGTCAACATTCTCTATACCGCCCCGACGGCC ATCCGCGCGCTGATGGCGGAAGGCGATAAAGCCATTGAAGGCACCGACCGTTCTTCACTG CGCATTCTGGGTTCCGTCGGCGAGCCGATCAATCCCGAAGCGTGGGAATGGTACTGGAAG AAGATCGGCAAGGAAAAATGTCCGGTCGTCGACACCTGGTGGCAGACTGAAACAGGCGGT TTTATGATCACGCCGCTACCAGGCGCTATCGAACTGAAAGCCGGTTCCGCCACCCGTCCT TTCTTTGGCGTACAGCCTGCGCTGGTGGATAACGAAGGCCATCCGCAAGAAGGCGCGACG GAAGGCAATCTGGTCATCACCGATTCCTGGCCGGGCCAGGCGCGCACTCTGTTCGGCGAT CATGAACGTTTTGAGCAGACCTATTTCTCTACCTTTAAGAATATGTATTTCAGCGGCGAC GGCGCGCGTCGCGATGAGGACGGCTATTACTGGATCACCGGTCGCGTGGACGACGTGTTA AACGTCTCCGGCCACCGTCTGGGTACGGCGGAAATCGAGTCAGCGCTGGTGGCGCATCCG AAGATCGCCGAAGCGGCGGTGGTGGGTATTCCACACGCTATCAAAGGCCAGGCGATTTAC GCTTATGTGACGCTCAACCACGGCGAGGAGCCGTCGCCAGAACTGTACGCGGAGGTGCGC AACTGGGTACGTAAAGAGATTGGCCCACTGGCGACGCCGGACGTGCTGCACTGGACCGAC TCACTGCCAAAAACCCGTTCCGGCAAAATTATGCGCCGCATTTTGCGCAAAATCGCGGCG GGCGATACCAGCAATCTGGGCGATACCTCGACTCTCGCCGATCCTGGCGTGGTGGAGAAA CTGCTCGAAGAGAAGCAGGCCATCGCGATGCCGTCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8ZKF6 UniProtKB Entry Name ACSA_SALTY GenBank Protein ID 16422835 GenBank Gene ID AE008900 - General References
- McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
- Starai VJ, Celic I, Cole RN, Boeke JD, Escalante-Semerena JC: Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science. 2002 Dec 20;298(5602):2390-2. [Article]
- Starai VJ, Escalante-Semerena JC: Identification of the protein acetyltransferase (Pat) enzyme that acetylates acetyl-CoA synthetase in Salmonella enterica. J Mol Biol. 2004 Jul 23;340(5):1005-12. [Article]
- Gulick AM, Starai VJ, Horswill AR, Homick KM, Escalante-Semerena JC: The 1.75 A crystal structure of acetyl-CoA synthetase bound to adenosine-5'-propylphosphate and coenzyme A. Biochemistry. 2003 Mar 18;42(10):2866-73. [Article]
- Reger AS, Carney JM, Gulick AM: Biochemical and crystallographic analysis of substrate binding and conformational changes in acetyl-CoA synthetase. Biochemistry. 2007 Jun 5;46(22):6536-46. Epub 2007 May 12. [Article]