Ryanodine receptor 2
Details
- Name
- Ryanodine receptor 2
- Synonyms
- Cardiac muscle ryanodine receptor
- Cardiac muscle ryanodine receptor-calcium release channel
- RYR-2
- Type 2 ryanodine receptor
- Gene Name
- RYR2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009057|Ryanodine receptor 2 MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTVEKSEGQVDVEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAWSGSHIRWGQPFRLRHV TTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSSKEKLDVGVRKEVDGMGTSEIKYGDSV CYIQHVDTGLWLTYQSVDVKSVRMGSIQRKAIMHHEGHMDDGISLSRSQHEESRTARVIR STVFLFNRFIRGLDALSKKAKASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLR ALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAAL IRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIF LGVSEGSAQYKKWYYELMVDHTEPFVTAEATHLRVGWASTEGYSPYPGGGEEWGGNGVGD DLFSYGFDGLHLWSGCIARTVSSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFE NFNIDGLFFPVVSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREY KQERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLKTLLALGCHVGISDEHAEDK VKKMKLPKNYQLTSGYKPAPMDLSFIKLTPSQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDVKNRRNPRLVPYTLLDDRTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSG TGERFRIFRAEKTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGF KAQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELAFKDFDVGDG FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPSNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQNSNTDIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSRLKQRFLLRRTKPDYSTSHSARLTEDVLADDRDDYDFLMQTSTYYYSVRIFPGQEPAN VWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMVCAGESMSPGQGR NNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRI KNVMPLSAGLFKSEHKNPVPQCPPRLHVQFLSHVLWSRMPNQFLKVDVSRISERQGWLVQ CLDPLQFMSLHIPEENRSVDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHV DEPQLLYAIENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITLFP DENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILKSKTIQMLTEAVK EGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNEDLKHILQLIEPSVFKEAATPEEE SDTLEKELSVDDAKLQGAGEEEAKGGKRPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRH RIEAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFK DDKSECPCPEEIRDQLLDFHEDLMTHCGIELDEDGSLDGNSDLTIRGRLLSLVEKVTYLK KKQAEKPVESDSKKSSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVR ALPKTYTINGVSVEDTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPN LMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHLSY LLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEKVVRYLAGCGLQSCQML VSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGG NGLLAAMEEAIKIAEDPSRDGPSPNSGSSKTLDTEEEEDDTIHMGNAIMTFYSALIDLLG RCAPEMHLIHAGKGEAIRIRSILRSLIPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGF CPDHKAAMVLFLDRVYGIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYL CTAVLPLLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSICGQL RPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGGWGNFGAASEEELHL SRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGALPPDYMESNYVSMMEKQSSMDSEGN FNPQPVDTSNITIPEKLEYFINKYAEHSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPY KLLSEKEKEIYRWPIKESLKTMLAWGWRIERTREGDSMALYNRTRRISQTSQVSVDAAHG YSPRAIDMSNVTLSRDLHAMAEMMAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAK EKAKDREKAQDILKFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYI LEFDGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSGGHASNKE KEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLESVKSALRAF LDNAAEDLEKTMENLKQGQFTHTRNQPKGVTQIINYTTVALLPMLSSLFEHIGQHQFGED LILEDVQVSCYRILTSLYALGTSKSIYVERQRSALGECLAAFAGAFPVAFLETHLDKHNI YSIYNTKSSRERAALSLPTNVEDVCPNIPSLEKLMEEIVELAESGIRYTQMPHVMEVILP MLCSYMSRWWEHGPENNPERAEMCCTALNSEHMNTLLGNILKIIYNNLGIDEGAWMKRLA VFSQPIINKVKPQLLKTHFLPLMEKLKKKAATVVSEEDHLKAEARGDMSEAELLILDEFT TLARDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIYWSKSHNFKREEQNFV VQNEINNMSFLITDTKSKMSKAAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPIGLNI CAPGDQELIALAKNRFSLKDTEDEVRDIIRSNIHLQGKLEDPAIRWQMALYKDLPNRTDD TSDPEKTVERVLDIANVLFHLEQKSKRVGRRHYCLVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGAEPPEEDEGTKR VDPLHQLILLFSRTALTEKCKLEEDFLYMAYADIMAKSCHDEEDDDGEEEVKSFEEKEME KQKLLYQQARLHDRGAAEMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDY LKEKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLF RFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDE QGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQ DSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMF LKLKDLTSSDTFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDY EEFVKRFHEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIEIMG SAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEM QLAAQISESDLNERSANKEESEKERPEEQGPRMAFFSILTVRSALFALRYNILTLMRMLS LKSLKKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICSLLLGGSLVE GAKKIKVAELLANMPDPTQDEVRGDGEEGERKPLEAALPSEDLTDLKELTEESDLLSDIF GLDLKREGGQYKLIPHNPNAGLSDLMSNPVPMPEVQEKFQEQKAKEEEKEEKEETKSEPE KAEGEDGEKEEKAKEDKGKQKLRQLHTHRYGEPEVPESAFWKKIIAYQQKLLNYFARNFY NMRMLALFVAFAINFILLFYKVSTSSVVEGKELPTRSSSENAKVTSLDSSSHRIIAVHYV LEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQ PSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGRDRISELLGMDKAALDFS DAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFA AHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGD TPDMKCDDMLTCYMFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLA IIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLF FLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN
- Number of residues
- 4967
- Molecular Weight
- 564562.71
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium channel activity / calcium ion binding / calcium-induced calcium release activity / calcium-release channel activity / calmodulin binding / enzyme binding / identical protein binding / intracellular ligand-gated calcium channel activity / ion channel binding / protein kinase A catalytic subunit binding / protein kinase A regulatory subunit binding / ryanodine-sensitive calcium-release channel activity / suramin bindingProcessesBMP signaling pathway / calcium ion transport / calcium ion transport into cytosol / calcium-mediated signaling / calcium-mediated signaling using intracellular calcium source / canonical Wnt signaling pathway / cardiac muscle contraction / cardiac muscle hypertrophy / cell communication by electrical coupling involved in cardiac conduction / cellular calcium ion homeostasis / cellular response to caffeine / cellular response to epinephrine stimulus / cytosolic calcium ion homeostasis / detection of calcium ion / embryonic heart tube morphogenesis / establishment of protein localization to endoplasmic reticulum / ion transmembrane transport / left ventricular cardiac muscle tissue morphogenesis / positive regulation of calcium-transporting ATPase activity / positive regulation of heart rate / positive regulation of sequestering of calcium ion / positive regulation of the force of heart contraction / Purkinje myocyte to ventricular cardiac muscle cell signaling / regulation of atrial cardiac muscle cell action potential / regulation of AV node cell action potential / regulation of cardiac muscle contraction / regulation of cardiac muscle contraction by calcium ion signaling / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of heart rate / regulation of SA node cell action potential / regulation of ventricular cardiac muscle cell action potential / release of sequestered calcium ion into cytosol / release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / response to caffeine / response to hypoxia / response to muscle activity / response to muscle stretch / response to redox state / sarcoplasmic reticulum calcium ion transport / transmembrane transport / type B pancreatic cell apoptotic process / ventricular cardiac muscle cell action potentialComponentscalcium channel complex / cytosol / extracellular exosome / junctional sarcoplasmic reticulum membrane / membrane / plasma membrane / protein complex / sarcoplasmic reticulum / sarcoplasmic reticulum membrane / smooth endoplasmic reticulum / Z disc
- General Function
- Suramin binding
- Specific Function
- Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
- Pfam Domain Function
- Transmembrane Regions
- 4282-4302 4504-4524 4580-4600 4730-4750 4769-4789 4850-4870
- Cellular Location
- Sarcoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0013589|Ryanodine receptor 2 (RYR2) ATGGCCGATGGGGGCGAGGGCGAAGACGAGATCCAGTTCCTGCGAACTGATGATGAAGTG GTTCTGCAGTGCACCGCAACCATCCACAAAGAACAACAGAAGCTATGCTTGGCAGCAGAA GGATTTGGCAACAGACTTTGTTTCTTGGAGTCCACTTCCAATTCCAAGAATGTGCCCCCA GACCTCTCCATCTGCACCTTTGTGCTGGAGCAGTCCCTCTCTGTCCGGGCGCTGCAGGAG ATGCTGGCTAACACCGTGGAGAAATCAGAAGGGCAAGTTGATGTGGAAAAATGGAAATTC ATGATGAAGACTGCTCAAGGTGGTGGTCATCGAACACTCCTCTACGGACATGCCATATTG CTGCGCCATTCCTATAGTGGCATGTATCTGTGCTGCCTGTCCACCTCCCGGTCTTCAACT GATAAGCTGGCTTTTGATGTTGGCTTGCAAGAGGACACCACAGGGGAGGCTTGTTGGTGG ACCATACACCCTGCCTCTAAGCAGCGATCAGAAGGAGAAAAAGTACGAGTTGGAGATGAC CTCATCTTAGTTAGCGTGTCCTCTGAAAGGTACTTGCACTTGTCTTATGGCAACGGCAGC TTACACGTGGATGCCGCTTTCCAGCAGACTCTCTGGAGCGTGGCCCCAATCAGCTCAGGA AGTGAGGCAGCCCAAGGGTATCTCATTGGTGGTGATGTCCTCAGGTTGCTGCATGGACAC ATGGACGAGTGTCTCACTGTCCCTTCAGGAGAACATGGTGAAGAGCAGCGGAGAACTGTT CATTATGAAGGTGGCGCTGTGTCTGTTCATGCACGTTCCCTTTGGAGACTAGAGACGCTA AGAGTTGCGTGGAGTGGAAGCCACATAAGATGGGGACAGCCATTCCGACTACGCCATGTC ACAACAGGAAAATACTTGAGTCTCATGGAAGACAAAAACCTTCTACTCATGGACAAAGAG AAAGCTGATGTAAAATCAACAGCATTTACCTTCCGGTCTTCCAAGGAAAAATTGGATGTA GGGGTGAGAAAAGAAGTAGATGGCATGGGAACATCTGAAATAAAATACGGTGACTCAGTA TGCTATATACAACATGTAGACACAGGCCTATGGCTTACTTACCAGTCTGTGGACGTGAAA TCCGTGAGAATGGGATCTATACAACGTAAGGCTATTATGCATCATGAAGGCCACATGGAT GATGGCATAAGTTTGTCGAGATCCCAGCATGAAGAATCACGCACAGCCCGAGTTATCCGG AGCACAGTCTTCCTTTTCAATAGATTTATAAGGGGCCTTGATGCTCTCAGCAAGAAAGCG AAGGCTTCCACAGTCGATTTGCCTATAGAGTCCGTAAGCCTAAGTCTGCAGGATCTCATT GGCTACTTCCACCCCCCAGATGAGCATTTAGAGCATGAAGACAAACAGAACAGACTACGA GCCCTGAAGAATCGGCAAAATCTCTTCCAGGAAGAGGGAATGATCAACCTCGTGCTTGAG TGCATAGACCGTTTGCACGTCTACAGCAGTGCAGCACACTTTGCTGATGTTGCTGGGCGA GAAGCAGGAGAGTCTTGGAAATCCATTCTGAATTCTCTGTATGAGTTGCTGGCGGCTCTA ATTAGAGGAAATCGTAAAAACTGTGCTCAATTTTCTGGCTCCCTCGACTGGTTGATCAGC AGATTGGAAAGACTGGAAGCTTCTTCAGGCATTCTGGAAGTTTTACACTGTGTTTTAGTA GAAAGTCCAGAAGCTCTAAATATTATTAAAGAAGGACATATTAAATCTATTATCTCACTT TTAGACAAACATGGAAGAAATCACAAGGTTCTGGATGTCTTGTGCTCACTCTGTGTTTGC CACGGGGTTGCAGTCCGTTCTAACCAGCATCTCATCTGTGACAATCTCCTACCAGGAAGA GACTTGTTATTGCAGACACGTCTTGTGAACCATGTCAGCAGCATGAGACCCAATATTTTT CTGGGCGTCAGTGAAGGTTCTGCTCAGTATAAGAAATGGTACTATGAATTGATGGTGGAC CACACAGAGCCCTTTGTGACAGCTGAAGCAACTCACCTGCGAGTGGGCTGGGCTTCCACT GAAGGATATTCTCCCTACCCTGGAGGGGGCGAAGAGTGGGGTGGAAATGGTGTTGGAGAT GATCTCTTCTCCTATGGATTTGATGGCCTTCATCTCTGGTCAGGTTGTATTGCTCGTACT GTAAGCTCACCAAACCAACATCTGTTAAGAACTGATGATGTCATCAGTTGCTGTTTAGAT CTGAGTGCCCCAAGCATCTCGTTCCGAATTAATGGACAACCTGTTCAAGGAATGTTTGAG AATTTCAACATCGATGGCCTCTTCTTTCCAGTCGTTAGTTTCTCTGCAGGAATAAAAGTA CGCTTTCTGCTTGGAGGGCGACATGGAGAATTCAAATTTCTTCCTCCACCTGGGTATGCT CCTTGTTATGAAGCTGTTCTGCCAAAAGAAAAGTTGAAAGTGGAACACAGCCGAGAGTAC AAGCAAGAAAGAACTTACACACGCGACCTGCTGGGCCCCACAGTTTCCCTGACGCAAGCT GCCTTCACACCCATCCCTGTGGATACCAGCCAGATCGTGTTGCCTCCTCATCTAGAAAGA ATAAGAGAAAAACTGGCAGAGAATATCCATGAACTCTGGGTTATGAATAAAATTGAGCTT GGCTGGCAGTATGGTCCGGTTAGAGATGACAACAAGAGACAACACCCATGCCTGGTGGAG TTCTCCAAGCTGCCTGAACAGGAGCGCAATTACAACTTACAAATGTCGCTTGAGACCCTG AAGACTTTGTTGGCATTAGGATGTCATGTGGGTATATCAGATGAACATGCTGAAGACAAG GTGAAAAAAATGAAGCTACCCAAGAATTACCAGCTGACAAGTGGATACAAGCCTGCCCCT ATGGACCTGAGCTTTATCAAACTCACCCCATCACAAGAAGCAATGGTGGACAAGTTGGCA GAAAATGCACATAATGTGTGGGCGCGGGATCGAATCCGGCAGGGCTGGACTTATGGCATC CAACAGGACGTAAAGAACAGAAGAAATCCTCGCCTTGTTCCCTACACTCTTCTGGATGAC CGAACCAAGAAATCCAACAAGGACAGCCTCCGCGAGGCTGTGCGCACGCTGCTGGGGTAC GGCTACAACTTGGAAGCACCAGATCAAGATCATGCAGCCAGAGCCGAAGTGTGCAGCGGC ACCGGGGAAAGGTTCCGAATCTTCCGTGCCGAGAAGACCTATGCAGTGAAGGCCGGACGG TGGTATTTTGAATTTGAGACGGTCACTGCTGGAGACATGAGGGTTGGTTGGAGTCGTCCT GGTTGTCAACCGGATCAGGAGCTTGGCTCAGATGAACGTGCCTTTGCCTTTGATGGCTTC AAGGCCCAGCGGTGGCATCAGGGCAATGAACACTATGGGCGCTCTTGGCAAGCAGGCGAT GTCGTGGGGTGTATGGTTGACATGAACGAACACACCATGATGTTCACACTGAATGGTGAA ATCCTTCTTGATGATTCAGGCTCAGAACTGGCTTTCAAGGACTTTGATGTTGGCGATGGA TTCATACCTGTGTGTAGCCTTGGAGTGGCTCAAGTGGGTAGGATGAACTTTGGAAAGGAT GTCAGCACCTTGAAATATTTCACCATCTGTGGCTTACAAGAGGGCTATGAACCATTTGCC GTTAATACAAACAGGGATATTACCATGTGGCTGAGCAAGAGGCTTCCTCAGTTTCTTCAA GTTCCATCAAACCATGAACATATAGAGGTGACCAGAATAGACGGCACCATAGACAGTTCC CCATGTTTAAAGGTCACTCAGAAGTCTTTTGGTTCTCAGAACAGCAACACTGATATCATG TTTTATCGCCTGAGCATGCCGATCGAGTGCGCGGAGGTCTTCTCCAAGACGGTGGCTGGA GGGCTCCCTGGGGCTGGCCTTTTTGGGCCCAAGAATGACTTGGAAGATTATGATGCTGAT TCTGACTTTGAGGTTCTGATGAAGACAGCTCATGGCCATCTAGTGCCCGATCGTGTTGAC AAAGACAAAGAAGCTACTAAACCAGAGTTTAACAACCACAAAGATTATGCCCAGGAAAAG CCCTCTCGTCTGAAACAAAGATTTTTGCTTAGAAGAACAAAGCCAGATTACAGCACAAGC CATTCTGCAAGACTCACCGAAGATGTCCTTGCTGATGATCGGGATGACTATGATTTCTTG ATGCAAACGTCCACGTACTATTACTCAGTGAGAATCTTTCCTGGACAAGAACCTGCTAAT GTCTGGGTGGGCTGGATTACATCAGATTTCCATCAGTATGACACAGGCTTTGACTTGGAC AGAGTTCGCACAGTAACAGTTACTCTAGGAGATGAAAAAGGAAAAGTGCATGAAAGCATC AAACGCAGCAACTGCTATATGGTATGTGCGGGTGAGAGCATGAGCCCCGGGCAAGGACGC AACAATAATGGACTGGAGATTGGCTGTGTGGTGGATGCTGCCAGCGGGCTGCTCACATTC ATTGCCAATGGCAAGGAACTGAGCACATACTATCAGGTGGAACCGAGTACAAAATTATTT CCTGCGGTTTTTGCACAAGCTACAAGTCCCAATGTTTTCCAGTTTGAGTTGGGAAGAATA AAGAATGTGATGCCTCTCTCGGCGGGATTATTCAAGAGTGAGCACAAGAACCCCGTGCCG CAGTGCCCCCCGCGCCTCCACGTGCAGTTCCTGTCACACGTCCTGTGGAGCAGAATGCCC AACCAGTTTTTGAAGGTAGATGTGTCTCGAATAAGTGAACGCCAAGGCTGGTTGGTGCAG TGTTTGGATCCTCTGCAGTTCATGTCTCTTCATATCCCTGAGGAAAACAGATCTGTTGAC ATCTTAGAGTTGACAGAGCAGGAGGAATTGCTGAAATTTCACTATCACACTCTCCGGCTC TACTCAGCCGTCTGTGCTCTTGGGAACCACCGGGTGGCCCATGCCCTGTGCAGCCATGTG GATGAACCTCAGCTCCTCTATGCCATTGAGAACAAGTACATGCCTGGTTTGCTGCGTGCT GGCTACTATGACCTGCTGATTGACATCCACCTGAGCTCCTATGCCACTGCCAGGCTCATG ATGAACAACGAGTACATTGTCCCCATGACGGAGGAGACGAAGAGCATCACCCTGTTCCCT GATGAGAACAAAAAACACGGCCTTCCAGGGATCGGCCTCAGCACCTCCCTCAGGCCACGG ATGCAGTTTTCCTCCCCCAGTTTTGTAAGCATTAGTAATGAATGTTACCAGTACAGTCCA GAGTTCCCACTGGACATCCTCAAGTCCAAAACCATACAGATGCTGACAGAAGCTGTTAAA GAGGGCAGTCTTCATGCCCGGGACCCAGTTGGAGGGACTACTGAATTCCTCTTTGTACCT CTCATCAAGCTTTTCTATACCCTGCTGATCATGGGCATCTTTCACAACGAGGACTTGAAG CACATCTTGCAGTTGATTGAGCCCAGTGTGTTTAAAGAAGCTGCCACTCCGGAGGAGGAG AGTGACACGCTGGAGAAAGAGCTCAGTGTGGACGATGCAAAGCTGCAAGGAGCTGGTGAG GAAGAAGCCAAGGGGGGCAAGCGGCCCAAGGAAGGCCTGCTCCAAATGAAACTGCCAGAG CCAGTTAAATTGCAGATGTGCCTACTGCTTCAGTACCTCTGTGACTGCCAGGTCCGGCAC CGGATAGAAGCCATTGTAGCCTTTTCAGATGATTTTGTGGCTAAGCTCCAAGACAATCAA CGTTTCCGATACAACGAAGTCATGCAAGCCTTAAACATGTCAGCTGCACTCACAGCCAGG AAGACAAAGGAATTTAGATCACCACCTCAAGAACAGATCAATATGCTTCTCAATTTTAAG GATGACAAAAGTGAATGTCCATGTCCAGAAGAAATTCGTGACCAACTATTGGATTTCCAT GAAGATTTGATGACACATTGTGGAATTGAGCTGGATGAAGATGGGTCTCTGGATGGAAAC AGTGATTTAACAATTAGAGGGCGTCTGCTATCCCTGGTAGAAAAGGTGACATATCTGAAG AAGAAGCAAGCAGAAAAACCAGTTGAGAGTGACTCCAAAAAGTCCTCCACTCTGCAGCAG CTGATTTCTGAGACCATGGTCCGATGGGCTCAGGAGTCTGTCATTGAAGACCCCGAGCTG GTGAGGGCCATGTTTGTGTTGCTCCATCGGCAGTATGACGGCATTGGGGGTCTTGTTCGG GCCCTGCCAAAGACCTACACGATAAATGGTGTGTCCGTGGAGGACACCATCAACCTGCTG GCATCCCTTGGTCAGATTCGGTCCCTGCTGAGTGTGAGAATGGGCAAAGAAGAAGAGAAG CTCATGATTCGTGGATTAGGGGATATTATGAATAACAAAGTGTTTTACCAGCACCCTAAT CTCATGAGGGCACTGGGGATGCACGAGACTGTGATGGAGGTCATGGTGAACGTCCTTGGA GGTGGAGAGTCCAAGGAAATCACCTTTCCCAAGATGGTGGCCAACTGTTGCCGTTTTCTC TGTTACTTCTGTCGTATAAGTAGGCAGAATCAAAAAGCTATGTTTGATCATCTCAGTTAT TTACTGGAAAACAGCAGTGTTGGTCTTGCCTCCCCAGCTATGAGAGGTTCAACACCACTG GATGTGGCTGCAGCTTCGGTGATGGATAATAATGAACTAGCATTAGCTCTGCGTGAGCCG GATCTAGAAAAGGTAGTTCGTTATTTGGCTGGTTGTGGACTGCAAAGTTGCCAGATGCTG GTGTCTAAGGGCTATCCAGACATTGGGTGGAACCCAGTTGAAGGAGAGAGATATCTTGAC TTTCTTAGATTTGCTGTCTTCTGTAATGGGGAGAGTGTGGAGGAAAATGCAAATGTCGTG GTGAGATTGCTCATTCGGAGGCCTGAGTGTTTTGGTCCTGCTTTGAGAGGAGAAGGTGGG AATGGGCTTCTTGCAGCAATGGAAGAAGCCATCAAAATCGCCGAGGATCCTTCCCGAGAT GGTCCCTCACCAAATAGCGGATCCAGTAAAACACTTGACACAGAGGAGGAGGAAGATGAC ACTATCCACATGGGGAACGCGATCATGACCTTCTATTCAGCTTTGATTGACCTCTTGGGA CGCTGTGCTCCTGAGATGCATTTGATTCATGCCGGGAAGGGAGAAGCCATCAGAATTAGG TCCATTTTGAGATCCCTCATTCCCCTGGGAGATTTGGTGGGCGTTATCAGCATCGCTTTT CAGATGCCAACAATAGCCAAAGATGGGAATGTGGTGGAACCTGACATGTCTGCGGGGTTT TGCCCAGATCACAAGGCAGCCATGGTTTTATTCCTTGACAGGGTCTATGGGATTGAGGTT CAAGACTTCCTCCTCCATCTTCTTGAGGTTGGCTTTCTGCCAGATCTCCGGGCGGCTGCT TCTTTAGATACGGCAGCTTTGAGTGCTACAGACATGGCCTTGGCCCTCAATCGGTACCTT TGCACAGCCGTCTTGCCATTGTTAACAAGATGTGCTCCTCTCTTTGCTGGCACAGAGCAC CACGCTTCTCTCATTGACTCATTACTTCATACTGTGTATAGACTTTCTAAGGGCTGTTCA CTTACCAAAGCTCAGCGGGATTCCATAGAAGTTTGTTTACTCTCTATTTGTGGACAACTG AGACCTTCTATGATGCAGCACTTACTCAGAAGATTAGTATTTGATGTTCCATTATTAAAT GAACACGCAAAGATGCCTCTTAAACTGCTGACAAATCATTATGAAAGATGCTGGAAATAT TACTGCCTGCCTGGAGGGTGGGGAAACTTTGGTGCTGCCTCAGAAGAAGAACTTCATTTA TCAAGAAAGTTGTTCTGGGGCATTTTTGATGCCCTGTCTCAAAAGAAATATGAACAAGAA CTTTTCAAACTGGCACTGCCTTGCCTGAGTGCAGTTGCGGGAGCTTTGCCTCCAGACTAC ATGGAGTCAAATTATGTCAGTATGATGGAAAAACAGTCATCAATGGATTCTGAAGGGAAC TTTAACCCACAACCTGTTGATACCTCAAATATTACAATTCCTGAGAAATTGGAATACTTC ATTAACAAATATGCAGAACACTCCCATGACAAATGGTCAATGGACAAGTTGGCAAATGGA TGGATTTATGGAGAAATATATTCAGACTCTTCTAAGGTTCAGCCATTAATGAAGCCATAT AAGCTATTGTCTGAAAAGGAAAAAGAAATTTATCGCTGGCCAATCAAAGAATCTTTAAAA ACTATGCTGGCTTGGGGCTGGAGAATTGAAAGAACTCGGGAGGGAGACAGCATGGCCCTT TACAACCGGACTCGTCGTATTTCTCAGACAAGCCAGGTTTCTGTGGACGCTGCCCATGGT TACAGTCCCCGGGCCATTGACATGAGCAATGTTACACTATCTAGAGACCTGCATGCTATG GCAGAAATGATGGCTGAAAACTACCATAATATATGGGCAAAGAAAAAGAAAATGGAGTTG GAGTCCAAAGGAGGAGGAAACCATCCTCTGCTGGTGCCCTATGATACACTGACAGCCAAA GAGAAAGCCAAGGATAGAGAAAAAGCACAGGACATCCTCAAGTTCTTGCAGATCAATGGA TATGCTGTATCCAGAGGATTTAAGGACCTGGAACTGGACACGCCTTCTATTGAGAAACGA TTTGCCTATAGTTTCCTCCAACAACTCATTCGCTATGTGGATGAAGCCCATCAGTATATC CTGGAGTTTGATGGTGGCAGCAGAGGCAAAGGAGAACATTTCCCTTATGAACAAGAAATC AAGTTCTTTGCAAAAGTCGTTCTTCCTTTAATTGATCAGTATTTCAAAAACCATCGTTTA TACTTCTTATCTGCAGCAAGCAGACCTCTCTGCTCTGGAGGACATGCTTCCAACAAAGAG AAAGAAATGGTGACTAGCCTATTCTGCAAACTTGGAGTTCTTGTCAGGCATAGGATTTCA CTATTTGGCAATGATGCAACATCAATTGTCAACTGTCTTCATATTTTGGGTCAGACTTTG GATGCAAGGACAGTGATGAAGACTGGCCTGGAGAGTGTTAAAAGTGCACTCAGAGCTTTT CTGGACAACGCTGCAGAGGATCTGGAGAAGACCATGGAAAACCTCAAGCAGGGCCAGTTC ACTCACACCCGAAACCAGCCCAAAGGGGTTACTCAGATTATCAATTACACCACAGTGGCC CTGCTGCCAATGCTGTCTTCATTATTTGAACATATTGGCCAGCATCAGTTCGGAGAAGAC CTAATATTGGAAGATGTCCAGGTGTCTTGTTATAGAATTCTGACTAGCTTATATGCTTTG GGAACCAGCAAGAGTATTTACGTGGAGAGGCAACGTTCTGCATTAGGAGAATGTCTAGCT GCCTTTGCTGGTGCTTTTCCTGTAGCATTTTTGGAAACTCATCTGGACAAACATAATATT TACTCCATCTACAATACCAAGTCTTCACGAGAAAGAGCAGCTCTCAGTTTGCCAACTAAT GTGGAAGATGTTTGTCCAAACATACCGTCTTTGGAGAAACTCATGGAAGAAATCGTGGAA TTAGCCGAGTCCGGCATTCGCTACACTCAAATGCCACATGTCATGGAAGTCATACTGCCC ATGCTTTGCAGCTACATGTCTCGTTGGTGGGAGCATGGACCTGAGAACAATCCAGAACGG GCCGAGATGTGCTGCACAGCCCTGAACTCAGAGCACATGAACACACTTCTAGGGAACATA TTGAAAATCATATATAATAACTTGGGGATTGATGAGGGAGCCTGGATGAAGAGGCTAGCA GTGTTTTCCCAGCCTATAATAAATAAAGTGAAACCTCAGCTCTTGAAAACTCATTTCTTG CCGTTAATGGAGAAACTCAAGAAAAAGGCAGCTACGGTGGTGTCTGAGGAAGACCACCTG AAAGCTGAGGCCAGGGGGGACATGTCGGAGGCAGAACTCCTCATCCTAGATGAGTTCACC ACACTGGCCAGAGATCTCTATGCCTTCTACCCTCTCTTGATTAGATTTGTGGACTATAAC AGGGCAAAGTGGCTAAAGGAGCCTAACCCAGAAGCAGAGGAGCTCTTCCGCATGGTGGCT GAAGTGTTTATCTACTGGTCGAAGTCCCATAATTTCAAAAGAGAAGAGCAGAACTTCGTT GTACAGAATGAAATCAACAATATGTCTTTCCTTATTACTGATACCAAGTCAAAGATGTCA AAGGCAGCTGTTTCTGATCAGGAAAGGAAGAAAATGAAGCGCAAAGGAGATCGGTATTCC ATGCAGACCTCTCTGATTGTAGCAGCTCTGAAGCGGTTACTGCCCATTGGGTTGAACATC TGTGCCCCTGGGGACCAGGAGCTCATTGCTCTGGCCAAAAATCGATTTAGCCTGAAAGAT ACCGAGGATGAAGTACGAGATATAATCCGCAGCAATATTCATTTACAAGGCAAGTTGGAG GATCCTGCTATTAGATGGCAAATGGCTCTTTACAAAGACTTACCAAACAGGACTGATGAT ACCTCAGATCCAGAGAAGACGGTAGAAAGAGTATTGGATATAGCAAATGTGCTTTTTCAT CTTGAACAGAAGTCTAAACGTGTGGGTCGGAGACATTACTGTCTGGTGGAACATCCTCAG AGATCTAAAAAGGCTGTATGGCATAAACTACTGTCCAAGCAGAGGAAAAGGGCTGTTGTA GCCTGCTTCCGGATGGCCCCCTTATATAATCTGCCAAGGCATCGGGCTGTCAATCTCTTT CTTCAGGGATATGAAAAGTCTTGGATTGAAACAGAAGAACATTACTTTGAAGATAAACTG ATAGAAGATTTAGCAAAACCTGGGGCTGAACCTCCAGAAGAAGATGAAGGCACTAAGAGA GTTGATCCTCTACATCAGCTGATCCTTCTGTTTAGTCGGACAGCTTTAACAGAGAAATGC AAACTGGAGGAAGATTTTTTATATATGGCCTATGCAGATATTATGGCAAAGAGTTGTCAT GATGAGGAAGATGACGATGGTGAAGAGGAAGTGAAGAGTTTTGAAGAAAAAGAAATGGAA AAGCAAAAGCTTCTATACCAGCAAGCCCGACTCCACGATCGTGGCGCGGCTGAGATGGTG CTACAGACAATCAGTGCCAGCAAAGGTGAAACTGGACCAATGGTAGCAGCTACTCTGAAA CTTGGAATTGCTATTTTAAATGGTGGGAACTCCACAGTACAGCAGAAAATGCTTGACTAC CTCAAGGAGAAAAAGGATGTGGGCTTCTTTCAGAGCCTGGCCGGCCTGATGCAGTCATGT AGTGTCCTTGACCTAAATGCATTTGAGCGACAAAACAAAGCTGAAGGTCTTGGGATGGTG ACAGAGGAAGGATCAGGAGAAAAGGTTCTGCAGGACGATGAGTTCACCTGTGACCTCTTC CGATTCCTGCAACTACTCTGTGAGGGACACAACTCAGATTTTCAGAATTATCTGAGAACT CAGACTGGCAATAATACAACTGTCAACATAATTATCTCCACTGTAGACTACCTACTGAGA GTTCAGGAATCAATTAGTGACTTTTATTGGTATTACTCTGGGAAAGATGTTATTGATGAA CAAGGACAACGGAATTTCTCCAAAGCTATCCAAGTGGCAAAACAAGTCTTTAACACTCTT ACAGAGTATATTCAGGGTCCTTGCACTGGGAATCAACAGAGTTTGGCACACAGCAGGCTG TGGGATGCTGTGGTCGGCTTTCTTCATGTGTTTGCCCATATGCAGATGAAGCTGTCGCAG GATTCCAGTCAAATTGAGCTATTAAAAGAATTAATGGATCTGCAGAAGGATATGGTGGTC ATGTTGCTGTCCATGTTAGAAGGTAATGTTGTTAATGGAACGATTGGCAAACAGATGGTG GATATGCTTGTGGAATCTTCCAACAACGTGGAGATGATTCTCAAATTTTTTGACATGTTC TTAAAACTAAAGGATTTGACGTCGTCTGATACTTTTAAAGAATATGACCCCGATGGCAAG GGAGTCATTTCCAAGAGGGACTTCCACAAAGCGATGGAGAGCCATAAGCACTACACGCAG TCAGAAACGGAATTTCTTTTGTCTTGTGCGGAGACGGATGAGAATGAAACCCTCGACTAC GAAGAGTTCGTCAAACGCTTCCACGAACCTGCGAAGGACATCGGCTTCAACGTCGCCGTC CTTCTGACAAACCTCTCTGAGCACATGCCCAACGATACCCGACTTCAGACTTTTCTGGAA TTAGCAGAGAGCGTCCTGAATTATTTCCAGCCCTTTCTGGGCCGCATCGAAATCATGGGA AGCGCCAAACGCATCGAGAGGGTCTATTTTGAAATCAGTGAGTCCAGCCGAACCCAGTGG GAGAAGCCCCAGGTCAAGGAGTCCAAAAGACAGTTCATATTTGACGTGGTCAACGAAGGC GGAGAGAAAGAGAAGATGGAACTCTTTGTGAACTTCTGCGAGGACACCATCTTTGAAATG CAGCTGGCGGCTCAGATCTCGGAGTCGGACTTGAACGAGAGGTCAGCGAATAAGGAAGAA AGCGAGAAGGAGAGGCCGGAAGAGCAGGGGCCGAGGATGGCTTTCTTCTCCATTCTGACG GTCAGGTCGGCCCTGTTTGCGCTCAGGTACAATATCTTGACCCTTATGCGAATGCTCAGT CTGAAGAGCCTGAAGAAGCAGATGAAAAAAGTAAAAAAGATGACCGTGAAGGACATGGTC ACGGCCTTCTTTTCATCCTACTGGAGTATTTTCATGACCCTCTTGCACTTCGTGGCCAGC GTTTTCAGAGGCTTTTTCCGCATCATTTGCAGCCTGCTGCTTGGGGGAAGCCTCGTCGAA GGTGCTAAAAAGATCAAAGTTGCAGAACTGTTAGCCAACATGCCAGACCCCACTCAGGAT GAGGTTAGAGGAGATGGGGAGGAGGGAGAGAGGAAACCCCTGGAAGCCGCCCTGCCCTCC GAGGATCTGACCGACTTAAAGGAGCTGACAGAGGAAAGTGACCTTCTTTCGGACATCTTT GGCCTGGATCTGAAGAGAGAAGGAGGACAGTACAAACTGATTCCTCATAATCCAAATGCT GGGCTCAGTGACCTCATGAGCAACCCAGTCCCCATGCCTGAGGTGCAGGAAAAATTTCAG GAACAGAAGGCAAAAGAAGAAGAAAAGGAAGAAAAAGAAGAAACCAAATCTGAACCTGAA AAAGCCGAGGGAGAAGATGGAGAAAAAGAAGAGAAAGCCAAGGAAGACAAGGGCAAACAA AAGTTGAGGCAGCTTCACACACACAGATACGGAGAACCAGAAGTGCCAGAGTCAGCATTC TGGAAGAAAATCATAGCATATCAACAGAAACTTCTAAACTATTTTGCTCGCAACTTTTAC AACATGAGAATGTTAGCCTTATTTGTCGCATTTGCTATCAATTTCATCTTGCTCTTTTAT AAGGTCTCCACTTCTTCTGTGGTTGAAGGAAAGGAGCTCCCCACGAGAAGTTCAAGTGAA AATGCCAAAGTGACAAGCCTGGACAGCAGCTCCCATAGAATCATCGCAGTTCACTATGTA CTAGAGGAGAGCAGCGGCTACATGGAGCCCACGTTGCGTATCTTAGCTATTCTGCACACG GTCATTTCTTTCTTCTGCATCATTGGATACTACTGCTTGAAAGTCCCATTGGTTATTTTT AAGCGAGAAAAGGAAGTGGCACGGAAATTGGAATTTGATGGGCTTTATATTACAGAACAG CCTTCAGAAGATGATATTAAAGGCCAGTGGGATAGACTCGTAATCAACACACAGTCATTT CCCAACAACTACTGGGACAAATTTGTTAAAAGAAAGGTTATGGATAAATATGGAGAGTTC TACGGCCGAGACAGAATCAGTGAATTACTTGGCATGGACAAGGCAGCTCTGGACTTCAGT GATGCCAGAGAAAAGAAGAAGCCAAAGAAAGACAGCTCCTTATCAGCTGTACTGAACTCC ATTGATGTGAAGTATCAGATGTGGAAACTAGGAGTCGTTTTCACTGACAACTCCTTCCTC TACCTAGCCTGGTATATGACTATGTCTGTTCTTGGACACTATAACAACTTTTTTTTTGCC GCTCACCTTCTCGACATTGCTATGGGATTCAAGACATTAAGAACCATCTTGTCCTCAGTA ACTCACAATGGCAAACAGCTCGTATTAACCGTTGGCTTATTAGCTGTTGTTGTATACCTA TACACTGTGGTGGCATTCAATTTTTTCCGAAAATTCTACAATAAAAGTGAAGATGGTGAT ACACCAGATATGAAATGTGACGATATGCTAACATGCTATATGTTCCACATGTATGTTGGA GTTCGTGCTGGAGGAGGGATCGGGGATGAAATCGAAGACCCAGCAGGAGATGAATATGAG ATCTATCGAATCATCTTTGACATCACTTTCTTCTTCTTTGTTATTGTCATTCTCTTGGCC ATAATACAAGGTCTAATTATTGATGCTTTTGGAGAACTAAGAGACCAACAGGAACAAGTC AAAGAAGACATGGAGACCAAATGCTTCATCTGTGGGATAGGCAATGATTACTTCGACACA GTGCCACATGGCTTTGAAACCCACACTTTACAGGAGCACAACTTGGCTAATTACTTGTTT TTTCTGATGTATCTTATAAACAAAGATGAAACAGAACACACAGGACAGGAATCTTATGTC TGGAAGATGTATCAAGAAAGGTGTTGGGAATTTTTCCCAGCAGGGGATTGCTTCCGGAAA CAGTATGAAGACCAGCTAAATTAA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q92736 UniProtKB Entry Name RYR2_HUMAN HGNC ID HGNC:10484 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB09085 Tetracaine approved, vet_approved yes modulator Details DB11093 Calcium citrate approved, investigational unknown substrate Details DB11348 Calcium Phosphate approved unknown substrate Details DB14481 Calcium phosphate dihydrate approved unknown Details DB01195 Flecainide approved, withdrawn unknown inhibitor Details