Ras-related protein Rab-8B
Details
- Name
- Ras-related protein Rab-8B
- Synonyms
- Not Available
- Gene Name
- RAB8B
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013133|Ras-related protein Rab-8B MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQ IWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILG NKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSANVEEAFFTLARDIMTKLNRKMNDS NSAGAGGPVKITENRSKKTSFFRCSLL
- Number of residues
- 207
- Molecular Weight
- 23583.84
- Theoretical pI
- Not Available
- GO Classification
- FunctionsGDP binding / GTP binding / GTPase activity / receptor bindingProcessesadherens junction organization / antigen processing and presentation / cellular response to insulin stimulus / Golgi vesicle fusion to target membrane / positive regulation of cell projection organization / positive regulation of corticotropin secretion / protein import into peroxisome membrane / protein localization to plasma membrane / protein secretion / Rab protein signal transduction / regulation of exocytosis / synaptic vesicle exocytosis / vesicle docking involved in exocytosisComponentscell tip / endosome / extracellular exosome / mitochondrion / perinuclear region of cytoplasm / peroxisomal membrane / phagocytic vesicle / phagocytic vesicle membrane / plasma membrane / secretory granule membrane / synaptic vesicle / trans-Golgi network transport vesicle
- General Function
- Receptor binding
- Specific Function
- The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity).
- Pfam Domain Function
- Ras (PF00071)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0013134|Ras-related protein Rab-8B (RAB8B) ATGGCGAAGACGTACGATTATCTCTTCAAGCTCCTGCTGATCGGCGACTCGGGGGTAGGC AAGACCTGCCTCCTGTTCCGCTTCTCAGAGGACGCCTTCAACACCACCTTCATCTCCACC ATCGGAATTGATTTTAAAATTAGAACGATAGAACTAGATGGAAAGAAAATTAAGCTTCAG ATATGGGACACAGCGGGTCAGGAAAGATTCCGAACAATCACGACAGCGTACTACAGAGGA GCCATGGGCATTATGCTGGTCTATGACATCACAAATGAAAAATCCTTTGACAATATTAAA AATTGGATCAGAAACATTGAAGAGCATGCCTCTTCCGATGTCGAAAGAATGATCCTGGGT AACAAATGTGATATGAATGACAAAAGACAAGTGTCAAAAGAAAGAGGGGAGAAGCTAGCA ATTGACTATGGGATTAAATTCTTGGAGACAAGCGCAAAATCCAGTGCAAATGTAGAAGAG GCATTTTTTACACTTGCACGAGATATAATGACAAAACTCAACAGAAAAATGAATGACAGC AATTCAGCAGGAGCAGGTGGACCAGTGAAAATAACAGAAAACCGATCAAAGAAGACCAGT TTCTTTCGTTGCTCGCTACTTTGA
- Chromosome Location
- 15
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q92930 UniProtKB Entry Name RAB8B_HUMAN HGNC ID HGNC:30273 - General References
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