Potassium voltage-gated channel subfamily B member 2
Details
- Name
- Potassium voltage-gated channel subfamily B member 2
- Synonyms
- Voltage-gated potassium channel subunit Kv2.2
- Gene Name
- KCNB2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0008573|Potassium voltage-gated channel subfamily B member 2 MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTR LGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFG QELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLW DLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVC IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKD SADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKL EMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKST SSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGP AARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFK ENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGP SKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSD GRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGD TGYCPTRETSM
- Number of residues
- 911
- Molecular Weight
- 102561.99
- Theoretical pI
- Not Available
- GO Classification
- Functionsdelayed rectifier potassium channel activity / protein heterodimerization activityProcessespotassium ion transmembrane transport / potassium ion transport / protein homooligomerization / protein targeting to plasma membrane / regulation of smooth muscle contraction / synaptic transmissionComponentsdendrite / integral component of membrane / intracellular / neuronal cell body membrane / perikaryon / plasma membrane / voltage-gated potassium channel complex
- General Function
- Protein heterodimerization activity
- Specific Function
- Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.
- Pfam Domain Function
- Transmembrane Regions
- 191-212 233-254 266-284 297-317 333-354 396-424
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0013282|Potassium voltage-gated channel subfamily B member 2 (KCNB2) ATGGCAGAAAAGGCTCCCCCGGGCTTAAACAGGAAGACTTCAAGGTCGACACTTTCCCTT CCTCCAGAGCCTGTGGACATTATCCGGAGCAAAACATGCTCCAGGAGAGTTAAGATCAAT GTGGGGGGCCTCAACCACGAAGTCCTGTGGAGAACGCTGGACAGGCTGCCCAGGACGCGC CTGGGGAAGCTTCGAGACTGCAACACACACGAGAGCCTCCTGGAAGTGTGCGACGACTAT AATCTGAACGAGAACGAGTATTTCTTTGATCGGCATCCAGGAGCCTTCACTTCCATTTTA AATTTCTACCGGACCGGGAAACTCCATATGATGGAAGAAATGTGTGCACTTTCGTTTGGC CAAGAACTTGATTACTGGGGGATTGATGAGATCTACTTGGAGTCCTGCTGCCAGGCCAGA TATCATCAAAAAAAAGAACAAATGAACGAAGAACTGAGGCGAGAGGCAGAGACTATGCGA GAGCGAGAAGGAGAAGAGTTTGATAATACCTGCTGCCCTGATAAAAGGAAGAAACTGTGG GACTTGCTGGAGAAACCTAACTCATCAGTGGCTGCAAAGATCCTGGCCATCGTGTCTATC CTGTTCATTGTGCTTTCCACCATTGCTTTGTCTCTCAATACGCTGCCGGAGCTGCAGGAA ACGGACGAATTTGGACAACTCAATGACAACCGCCAATTAGCACACGTGGAGGCTGTGTGT ATTGCATGGTTTACCATGGAGTACCTTTTGCGATTCTTATCCTCACCAAATAAATGGAAG TTCTTCAAAGGCCCACTGAATGTCATTGATTTGCTGGCCATCTTGCCGTACTATGTCACC ATTTTTCTGACGGAGTCCAACAAGAGCGTGCTGCAGTTCCAAAACGTGAGGCGCGTGGTC CAGATCTTCCGAATCATGCGCATCCTCAGGATCCTGAAACTCGCCAGGCATTCGACAGGC CTGCAGTCTCTGGGTTTCACCCTTAGGCGGAGTTACAATGAATTGGGCTTGTTGATATTG TTTCTGGCCATGGGGATAATGATATTTTCCAGCCTGGTATTTTTTGCTGAGAAGGATGAA GATGCTACCAAGTTCACCAGTATCCCTGCATCATTTTGGTGGGCCACCATCACCATGACC ACTGTTGGCTATGGTGACATTTACCCTAAAACATTACTAGGGAAAATTGTGGGAGGTCTG TGCTGTATTGCTGGGGTTCTGGTTATTGCCCTTCCTATCCCAATTATTGTGAACAATTTT TCTGAGTTTTACAAGGAGCAGAAACGCCAAGAGAAAGCAATTAAAAGGAGGGAGGCTCTT GAGCGGGCCAAAAGGAACGGAAGCATCGTTTCTATGAACTTAAAAGATGCCTTCGCTCGA AGTATGGAACTGATAGATGTGGCTGTTGAGAAGGCCGGAGAGTCCGCCAACACAAAGGAC TCCGCCGACGATAATCACCTGTCGCCAAGCCGGTGGAAGTGGGCCAGGAAGGCTCTGTCG GAAACAAGCTCCAACAAGTCTTTCGAGAATAAGTACCAGGAGGTTAGCCAAAAAGACTCC CACGAGCAGCTGAACAACACGTCTTCCTCCAGCCCACAGCATCTGAGTGCCCAGAAACTG GAGATGCTATACAATGAAATCACCAAGACACAGCCTCATTCTCACCCAAACCCAGACTGC CAAGAAAAGCCTGAGAGGCCATCTGCATATGAAGAAGAGATTGAAATGGAAGAAGTGGTG TGTCCACAGGAGCAGCTGGCCGTGGCACAGACCGAGGTCATTGTGGACATGAAGAGCACC TCCAGCATCGACAGCTTCACCAGCTGTGCCACCGACTTCACAGAGACAGAGAGATCGCCG CTGCCGCCGCCCTCCGCCTCTCACTTGCAGATGAAGTTCCCAACCGACCTCCCAGGGACA GAAGAGCACCAAAGAGCTAGGGGCCCCCCGTTTCTAACTCTATCCAGAGAGAAAGGACCT GCTGCCAGGGATGGCACGCTGGAGTATGCCCCAGTTGACATAACTGTGAACCTCGATGCC AGTGGCTCCCAGTGTGGGCTACATAGTCCTTTGCAGTCTGACAATGCCACCGACAGTCCT AAGAGCTCTCTAAAAGGCAGCAACCCACTAAAGTCCAGATCCCTCAAAGTGAACTTTAAG GAAAATAGAGGCAGTGCACCACAGACCCCGCCCAGCACAGCCAGGCCACTGCCAGTCACC ACAGCTGACTTTTCGCTCACTACCCCGCAGCACATCAGTACCATCCTCTTAGAAGAAACC CCCTCCCAGGGAGACAGACCCTTGCTGGGCACTGAGGTTTCAGCGCCTTGTCAGGGACCT TCCAAAGGGCTGTCCCCCAGGTTTCCCAAGCAGAAACTGTTCCCTTTCTCTTCAAGAGAG AGGAGGAGCTTCACTGAAATAGATACTGGTGACGACGAAGACTTCTTAGAGCTCCCAGGG GCAAGGGAGGAGAAGCAGGTGGACTCCAGCCCAAATTGCTTTGCAGATAAGCCTAGTGAT GGGAGAGACCCTTTAAGAGAAGAGGGCAGTGTGGGCTCTTCCTCCCCGCAGGACACAGGT CACAACTGTAGGCAAGACATTTACCATGCTGTGAGTGAAGTCAAAAAGGACAGTAGTCAA GAAGGGTGCAAGATGGAAAATCACTTGTTTGCCCCAGAAATTCATTCCAACCCAGGAGAC ACAGGTTATTGTCCCACACGTGAAACCAGCATGTGA
- Chromosome Location
- 8
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q92953 UniProtKB Entry Name KCNB2_HUMAN HGNC ID HGNC:6232 - General References
- Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, Kenyon JL, Horowitz B: Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am J Physiol. 1998 May;274(5 Pt 1):G901-11. [Article]
- Coetzee WA, Amarillo Y, Chiu J, Chow A, Lau D, McCormack T, Moreno H, Nadal MS, Ozaita A, Pountney D, Saganich M, Vega-Saenz de Miera E, Rudy B: Molecular diversity of K+ channels. Ann N Y Acad Sci. 1999 Apr 30;868:233-85. [Article]
- Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB06637 Dalfampridine approved yes antagonist Details DB00228 Enflurane approved, investigational, vet_approved unknown inhibitoractivator Details DB01069 Promethazine approved, investigational unknown inducer Details DB01110 Miconazole approved, investigational, vet_approved unknown inhibitor Details