Phosphopantothenoylcysteine decarboxylase

Details

Name
Phosphopantothenoylcysteine decarboxylase
Synonyms
  • 4.1.1.36
  • COAC
  • PPC-DC
Gene Name
PPCDC
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037218|Phosphopantothenoylcysteine decarboxylase
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFY
SPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLL
TCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGA
MAEVGTIVDKVKEVLFQHSGFQQS
Number of residues
204
Molecular Weight
22394.965
Theoretical pI
6.01
GO Classification
Functions
phosphopantothenoylcysteine decarboxylase activity
Processes
coenzyme A biosynthetic process / coenzyme biosynthetic process / pantothenate metabolic process / small molecule metabolic process / vitamin metabolic process / water-soluble vitamin metabolic process
Components
cytosol
General Function
Phosphopantothenoylcysteine decarboxylase activity
Specific Function
Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0020657|Phosphopantothenoylcysteine decarboxylase (PPCDC)
ATGGAACCAAAGGCCTCCTGTCCAGCTGCTGCACCCTTGATGGAGAGAAAATTCCATGTT
CTTGTGGGTGTCACGGGGAGTGTCGCAGCCCTGAAGTTGCCTCTTCTGGTGTCAAAGCTT
TTGGACATTCCTGGGCTGGAAGTAGCAGTGGTCACAACTGAGAGAGCCAAACATTTCTAC
AGCCCCCAGGACATTCCTGTCACCCTCTACAGCGACGCTGATGAATGGGAGACCTGCGTC
ATGCGGGCCTGGGACCGCAGCAAGCCCCTGCTCTTCTGCCCGGCCATGAACACCGCCATG
TGGGAGCACCCGATCACAGCGCAGCAGGTAGACCAGCTCAAGGCCTTTGGCTATGTCGAG
ATCCCCTGTGTGGCCAAGAAGCTGGTGTGCGGAGATGAAGGTCTCGGGGCCATGGCTGAA
GTGGGGACCATCGTGGACAAAGTGAAAGAAGTCCTCTTCCAGCACAGTGGCTTCCAGCAG
AGTTGA
Chromosome Location
15
Locus
15q24.2
External Identifiers
ResourceLink
UniProtKB IDQ96CD2
UniProtKB Entry NameCOAC_HUMAN
GenBank Gene IDAY358848
GenAtlas IDPPCDC
HGNC IDHGNC:28107
General References
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  3. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03738PantothenoylaminoethenethiolexperimentalunknownDetails
DB03247Flavin mononucleotideapproved, investigationalunknownDetails