Carboxypeptidase B2
Details
- Name
- Carboxypeptidase B2
- Synonyms
- 3.4.17.20
- Carboxypeptidase U
- CPU
- pCPB
- Plasma carboxypeptidase B
- TAFI
- Thrombin-activable fibrinolysis inhibitor
- Gene Name
- CPB2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037233|Carboxypeptidase B2 MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI RNV
- Number of residues
- 423
- Molecular Weight
- 48423.85
- Theoretical pI
- 7.77
- GO Classification
- Functionsmetallocarboxypeptidase activity / zinc ion bindingProcessesblood coagulation / cellular response to glucose stimulus / fibrinolysis / liver regeneration / negative regulation of fibrinolysis / negative regulation of hepatocyte proliferation / negative regulation of plasminogen activation / positive regulation of extracellular matrix constituent secretion / proteolysis / response to drug / response to heatComponentscell / extracellular exosome / extracellular space
- General Function
- Zinc ion binding
- Specific Function
- Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0012387|Carboxypeptidase B2 (CPB2) ATGAAGCTTTGCAGCCTTGCAGTCCTTGTACCCATTGTTCTCTTCTGTGAGCAGCATGTC TTCGCGTTTCAGAGTGGCCAAGTTCTAGCTGCTCTTCCTAGAACCTCTAGGCAAGTTCAA GTTCTACAGAATCTTACTACAACATATGAGATTGTTCTCTGGCAGCCGGTAACAGCTGAC CTTATTGTGAAGAAAAAACAAGTCCATTTTTTTGTAAATGCATCTGATGTCGACAATGTG AAAGCCCATTTAAATGTGAGCGGAATTCCATGCAGTGTCTTGCTGGCAGATGTGGAAGAT CTTATTCAACAGCAGATTTCCAACGACACAGTCAGCCCCCGAGCCTCCGCATCGTACTAT GAACAGTATCACTCACTAAATGAAATCTATTCTTGGATAGAATTTATAACTGAGAGGCAT CCTGATATGCTTACAAAAATCCACATTGGATCCTCATTTGAGAAGTACCCACTCTATGTT TTAAAGGTTTCTGGAAAAGAACAAGCAGCCAAAAATGCCATATGGATTGACTGTGGAATC CATGCCAGAGAATGGATCTCTCCTGCTTTCTGCTTGTGGTTCATAGGCCATAATCGAATG TGGAGAAAGAACCGTTCTTTCTATGCGAACAATCATTGCATCGGAACAGACCTGAATAGG AACTTTGCTTCCAAACACTGGTGTGAGGAAGGTGCATCCAGTTCCTCATGCTCGGAAACC TACTGTGGACTTTATCCTGAGTCAGAACCAGAAGTGAAGGCAGTGGCTAGTTTCTTGAGA AGAAATATCAACCAGATTAAAGCATACATCAGCATGCATTCATACTCCCAGCATATAGTG TTTCCATATTCCTATACACGAAGTAAAAGCAAAGACCATGAGGAACTGTCTCTAGTAGCC AGTGAAGCAGTTCGTGCTATTGAGAAAATTAGTAAAAATACCAGGTATACACATGGCCAT GGCTCAGAAACCTTATACCTAGCTCCTGGAGGTGGGGACGATTGGATCTATGATTTGGGC ATCAAATATTCGTTTACAATTGAACTTCGAGATACGGGCACATACGGATTCTTGCTGCCG GAGCGTTACATCAAACCCACCTGTAGAGAAGCTTTTGCCGCTGTCTCTAAAATAGCTTGG CATGTCATTAGGAATGTTTAA
- Chromosome Location
- 13
- Locus
- 13q14.11
- External Identifiers
Resource Link UniProtKB ID Q96IY4 UniProtKB Entry Name CBPB2_HUMAN GenBank Gene ID M75106 GenAtlas ID CPB2 HGNC ID HGNC:2300 - General References
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