Response regulator PleD

Details

Name
Response regulator PleD
Synonyms
  • Stalked cell differentiation-controlling protein
Gene Name
pleD
Organism
Caulobacter crescentus (strain ATCC 19089 / CB15)
Amino acid sequence
>lcl|BSEQ0016378|Response regulator PleD
MSARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIILLDVMMPGMD
GFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASDFLTKPIDDVMLFARVRSLT
RFKLVIDELRQREASGRRMGVIAGAAARLDGLGGRVLIVDDNERQAQRVAAELGVEHRPV
IESDPEKAKISAGGPVDLVIVNAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRM
VKALEIGVNDILSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNR
RYMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFALRLASNVRA
IDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFTVAHGREMLNVTISIGVSAT
AGEGDTPEALLKRADEGVYQAKASGRNAVVGKAA
Number of residues
454
Molecular Weight
49623.365
Theoretical pI
5.77
GO Classification
Functions
diguanylate cyclase activity / GTP binding / metal ion binding / signal transducer activity
Processes
cell cycle / cell differentiation / phosphorelay signal transduction system
Components
cytoplasm
General Function
Signal transducer activity
Specific Function
Response regulator that is part of a signal transduction pathway controlling cell differentiation in the swarmer-to-stalked cell transition.Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0016379|Response regulator PleD (pleD)
ATGAGCGCCCGGATCCTCGTCGTCGACGACATCGAGGCCAATGTCCGCCTGCTTGAGGCC
AAGCTGACGGCCGAGTACTATGAGGTCTCCACCGCCATGGACGGGCCGACGGCCCTGGCT
ATGGCCGCGCGCGATCTGCCCGACATCATTCTGCTGGACGTCATGATGCCCGGCATGGAC
GGCTTCACCGTCTGCCGTAAGCTGAAGGACGATCCGACTACCCGCCACATCCCGGTGGTG
CTGATCACCGCGCTCGACGGGCGTGGCGACCGCATCCAGGGCCTGGAATCGGGCGCTTCG
GACTTCCTGACCAAGCCGATCGACGACGTCATGCTGTTCGCCCGCGTGCGCAGCCTGACC
CGCTTCAAGCTGGTGATCGACGAACTGCGTCAGCGCGAGGCCTCGGGCCGCCGCATGGGC
GTGATCGCCGGCGCCGCCGCGCGCCTGGACGGTCTGGGCGGTCGGGTGCTGATCGTCGAC
GACAACGAACGCCAGGCTCAACGCGTCGCCGCCGAGCTGGGCGTCGAACACCGCCCGGTG
ATCGAGAGCGACCCTGAGAAGGCCAAGATCAGCGCCGGCGGTCCGGTCGACCTGGTCATC
GTCAACGCTGCGGCCAAGAACTTCGATGGCCTGCGCTTCACCGCCGCGCTGCGGTCCGAG
GAACGCACCCGCCAGTTGCCCGTGCTGGCCATGGTCGATCCCGATGATCGTGGCCGCATG
GTCAAGGCGCTGGAGATCGGCGTGAACGACATCCTGTCGCGCCCGATCGATCCGCAGGAA
CTGTCCGCGCGCGTCAAGACGCAGATCCAGCGCAAGCGCTACACTGACTATCTGCGCAAC
AATCTGGATCACTCGCTGGAGCTGGCCGTCACCGACCAGCTGACCGGCCTGCACAATCGC
CGCTACATGACCGGTCAGCTCGACTCGCTGGTCAAGCGCGCGACACTGGGCGGCGATCCG
GTTTCGGCCCTGCTGATCGACATCGATTTCTTCAAGAAAATCAACGACACCTTCGGTCAC
GATATCGGCGACGAGGTGCTGCGCGAGTTCGCCTTGCGTCTGGCCTCGAACGTCCGCGCC
ATTGATCTGCCTTGCCGCTATGGCGGGGAAGAGTTCGTGGTGATCATGCCCGACACCGCC
CTGGCTGACGCCCTGCGCATCGCCGAGCGGATCCGGATGCATGTCTCCGGCTCGCCCTTC
ACGGTCGCCCATGGCCGCGAAATGCTGAACGTCACCATCTCGATCGGCGTCTCGGCCACG
GCGGGCGAGGGCGACACGCCCGAAGCCCTGCTCAAGCGCGCCGACGAAGGCGTTTATCAG
GCCAAGGCCTCGGGTCGGAACGCGGTGGTCGGCAAGGCCGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9A5I5
UniProtKB Entry NamePLED_CAUCR
GenBank Protein ID1119215
GenBank Gene IDL42554
General References
  1. Hecht GB, Newton A: Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov;177(21):6223-9. [Article]
  2. Nierman WC, Feldblyum TV, Laub MT, Paulsen IT, Nelson KE, Eisen JA, Heidelberg JF, Alley MR, Ohta N, Maddock JR, Potocka I, Nelson WC, Newton A, Stephens C, Phadke ND, Ely B, DeBoy RT, Dodson RJ, Durkin AS, Gwinn ML, Haft DH, Kolonay JF, Smit J, Craven MB, Khouri H, Shetty J, Berry K, Utterback T, Tran K, Wolf A, Vamathevan J, Ermolaeva M, White O, Salzberg SL, Venter JC, Shapiro L, Fraser CM: Complete genome sequence of Caulobacter crescentus. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4136-41. Epub 2001 Mar 20. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01972Guanosine-5'-MonophosphateexperimentalunknownDetails