Serine/threonine-protein kinase 33

Details

Name
Serine/threonine-protein kinase 33
Synonyms
  • 2.7.11.1
Gene Name
STK33
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051650|Serine/threonine-protein kinase 33
MADSGLDKKSTKCPDCSSASQKDVLCVCSSKTRVPPVLVVEMSQTSSIGSAESLISLERK
KEKNINRDITSRKDLPSRTSNVERKASQQQWGRGNFTEGKVPHIRIENGAAIEEIYTFGR
ILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEHIIHLEQ
VFETPKKMYLVMELCEDGELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLK
LENIMVKSSLIDDNNEINLNIKVTDFGLAVKKQSRSEAMLQATCGTPIYMAPEVISAHDY
SQQCDIWSIGVVMYMLLRGEPPFLASSEEKLFELIRKGELHFENAVWNSISDCAKSVLKQ
LMKVDPAHRITAKELLDNQWLTGNKLSSVRPTNVLEMMKEWKNNPESVEENTTEEKNKPS
TEEKLKSYQPWGNVPDANYTSDEEEEKQSTAYEKQFPATSKDNFDMCSSSFTSSKLLPAE
IKGEMEKTPVTPSQGTATKYPAKSGALSRTKKKL
Number of residues
514
Molecular Weight
57830.355
Theoretical pI
Not Available
GO Classification
Functions
ATP binding / protein serine/threonine kinase activity
Processes
intracellular signal transduction / peptidyl-serine phosphorylation / peptidyl-threonine phosphorylation / protein autophosphorylation
Components
intracellular / perinuclear region of cytoplasm
General Function
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME (By similarity). Not essential for the survival of KRAS-dependent AML cell lines.
Specific Function
Atp binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0051651|Serine/threonine-protein kinase 33 (STK33)
ATGGCTGATAGTGGCTTAGATAAAAAATCCACAAAATGCCCCGACTGTTCATCTGCTTCT
CAGAAAGATGTACTTTGTGTATGTTCCAGCAAAACAAGGGTTCCTCCAGTTTTGGTGGTG
GAAATGTCACAGACATCAAGCATTGGTAGTGCAGAATCTTTAATTTCACTGGAGAGAAAA
AAAGAAAAAAATATCAACAGAGATATAACCTCCAGGAAAGATTTGCCCTCAAGAACCTCA
AATGTAGAGAGAAAAGCATCTCAGCAACAATGGGGTCGGGGCAACTTTACAGAAGGAAAA
GTTCCTCACATAAGGATTGAGAATGGAGCTGCTATTGAGGAAATCTATACCTTTGGAAGA
ATATTGGGAAAAGGGAGCTTTGGAATAGTCATTGAAGCGACAGACAAGGAAACAGAAACG
AAGTGGGCAATTAAAAAAGTGAACAAAGAAAAGGCTGGAAGCTCTGCTGTGAAGTTACTT
GAACGAGAGGTGAACATTCTGAAAAGTGTAAAACATGAACACATCATACATCTGGAACAA
GTATTTGAAACGCCAAAGAAAATGTACCTTGTGATGGAGCTTTGTGAGGATGGAGAACTC
AAAGAAATTCTGGATAGGAAAGGGCATTTCTCAGAGAATGAGACAAGGTGGATCATTCAA
AGTCTCGCATCAGCTATAGCATATCTTCACAATAATGATATTGTACATAGAGATCTGAAA
CTGGAAAATATAATGGTTAAAAGCAGTCTTATTGATGATAACAATGAAATAAACTTAAAC
ATAAAGGTGACTGATTTTGGCTTAGCGGTGAAGAAGCAAAGTAGGAGTGAAGCCATGCTG
CAGGCCACATGTGGGACTCCTATCTATATGGCCCCTGAAGTTATCAGTGCCCACGACTAT
AGCCAGCAGTGTGACATTTGGAGCATAGGCGTCGTAATGTACATGTTATTACGTGGAGAA
CCACCCTTTTTGGCAAGCTCAGAAGAGAAGCTTTTTGAGTTAATAAGAAAAGGAGAACTA
CATTTTGAAAATGCAGTCTGGAATTCCATAAGTGACTGTGCTAAAAGTGTTTTGAAACAA
CTTATGAAAGTAGATCCTGCTCACAGAATCACAGCTAAGGAACTACTAGATAACCAGTGG
TTAACAGGCAATAAACTTTCTTCGGTGAGACCAACCAATGTATTAGAGATGATGAAGGAA
TGGAAAAATAACCCAGAAAGTGTTGAGGAAAACACAACAGAAGAGAAGAATAAGCCGTCC
ACTGAAGAAAAGTTGAAAAGTTACCAACCCTGGGGAAATGTCCCTGATGCCAATTACACT
TCAGATGAAGAGGAGGAAAAACAGTCTACTGCTTATGAAAAGCAATTTCCTGCAACCAGT
AAGGACAACTTTGATATGTGCAGTTCAAGTTTCACATCTAGCAAACTCCTTCCAGCTGAA
ATCAAGGGAGAAATGGAGAAAACCCCTGTGACTCCAAGCCAAGGAACAGCAACCAAGTAC
CCTGCTAAATCCGGCGCCCTGTCCAGAACCAAAAAGAAACTCTAA
Chromosome Location
11
Locus
11p15.4
External Identifiers
ResourceLink
UniProtKB IDQ9BYT3
UniProtKB Entry NameSTK33_HUMAN
HGNC IDHGNC:14568
General References
  1. Mujica AO, Hankeln T, Schmidt ER: A novel serine/threonine kinase gene, STK33, on human chromosome 11p15.3. Gene. 2001 Dec 12;280(1-2):175-81. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  5. Mujica AO, Brauksiepe B, Saaler-Reinhardt S, Reuss S, Schmidt ER: Differential expression pattern of the novel serine/threonine kinase, STK33, in mice and men. FEBS J. 2005 Oct;272(19):4884-98. [Article]
  6. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
  7. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
  8. Babij C, Zhang Y, Kurzeja RJ, Munzli A, Shehabeldin A, Fernando M, Quon K, Kassner PD, Ruefli-Brasse AA, Watson VJ, Fajardo F, Jackson A, Zondlo J, Sun Y, Ellison AR, Plewa CA, San MT, Robinson J, McCarter J, Schwandner R, Judd T, Carnahan J, Dussault I: STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Cancer Res. 2011 Sep 1;71(17):5818-26. doi: 10.1158/0008-5472.CAN-11-0778. Epub 2011 Jul 8. [Article]
  9. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB12010Fostamatinibapproved, investigationalunknowninhibitorDetails