Matrix metalloproteinase-28
Details
- Name
- Matrix metalloproteinase-28
- Synonyms
- 3.4.24.-
- Epilysin
- MMP-28
- MMP25
- Gene Name
- MMP28
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007114|Matrix metalloproteinase-28 MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK KRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPAD IRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAH EIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLF TDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDA ALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFF RDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF
- Number of residues
- 520
- Molecular Weight
- 58938.525
- Theoretical pI
- 10.07
- GO Classification
- Functionscalcium ion binding / metalloendopeptidase activity / zinc ion bindingProcessesnegative regulation of macrophage chemotaxisComponentscytoplasm / proteinaceous extracellular matrix
- General Function
- Zinc ion binding
- Specific Function
- Can degrade casein. Could play a role in tissues homeostasis and repair.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0012579|Matrix metalloproteinase-28 (MMP28) ATGGTCGCGCGCGTCGGCCTCCTGCTGCGCGCCCTGCAGCTGCTACTGTGGGGCCACCTG GACGCCCAGCCCGCGGAGCGCGGAGGCCAGGAGCTGCGCAAGGAGGCGGAGGCATTCCTA GAGAAGTACGGATACCTCAATGAACAGGTCCCCAAAGCTCCCACCTCCACTCGATTCAGC GATGCCATCAGAGCGTTTCAGTGGGTGTCCCAGCTACCTGTCAGCGGCGTGTTGGACCGC GCCACCCTGCGCCAGATGACTCGTCCCCGCTGCGGGGTTACAGATACCAACAGTTATGCG GCCTGGGCTGAGAGGATCAGTGACTTGTTTGCTAGACACCGGACCAAAATGAGGCGTAAG AAACGCTTTGCAAAGCAAGGTGAGCACTGTTAA
- Chromosome Location
- 17
- Locus
- 17q11-q21.1
- External Identifiers
Resource Link UniProtKB ID Q9H239 UniProtKB Entry Name MMP28_HUMAN GenBank Protein ID 11935132 GenBank Gene ID AF315683 HGNC ID HGNC:14366 - General References
- Marchenko GN, Strongin AY: MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors. Gene. 2001 Mar 7;265(1-2):87-93. [Article]
- Lohi J, Wilson CL, Roby JD, Parks WC: Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem. 2001 Mar 30;276(13):10134-44. Epub 2000 Dec 19. [Article]
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