S-methylmethionine--homocysteine S-methyltransferase BHMT2
Details
- Name
- S-methylmethionine--homocysteine S-methyltransferase BHMT2
- Synonyms
- 2.1.1.10
- Betaine--homocysteine S-methyltransferase 2
- SMM-hcy methyltransferase
- Gene Name
- BHMT2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004414|S-methylmethionine--homocysteine S-methyltransferase BHMT2 MAPAGRPGAKKGILERLESGEVVIGDGSFLITLEKRGYVKAGLWTPEAVIEHPDAVRQLH MEFLRAGSNVMQTFTFSASEDNMESKWEDVNAAACDLAREVAGKGDALVAGGICQTSIYK YQKDEARIKKLFRQQLEVFAWKNVDFLIAEYFEHVEEAVWAVEVLKESDRPVAVTMCIGP EGDMHDITPGECAVRLVKAGASIVGVNCRFGPDTSLKTMELMKEGLEWAGLKAHLMVQPL GFHAPDCGKEGFVDLPEYPFGLESRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRA IAEELAPERGFLPPASEKHGSWGSGLDMHTKPWIRARARREYWENLLPASGRPFCPSLSK PDF
- Number of residues
- 363
- Molecular Weight
- 40353.84
- Theoretical pI
- 5.68
- GO Classification
- FunctionsS-adenosylmethionine-homocysteine S-methyltransferase activity / S-methylmethionine-homocysteine S-methyltransferase activity / zinc ion bindingProcessescellular nitrogen compound metabolic process / L-methionine salvage / S-adenosylmethionine metabolic process / S-methylmethionine cycle / S-methylmethionine metabolic process / small molecule metabolic process / sulfur amino acid metabolic processComponentscytosol / extracellular exosome
- General Function
- Zinc ion binding
- Specific Function
- Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.
- Pfam Domain Function
- S-methyl_trans (PF02574)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011622|S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2) ATGGCACCTGCTGGACGCCCGGGGGCCAAGAAGGGGATTTTGGAGCGCCTGGAGAGTGGG GAGGTTGTGATTGGAGATGGCAGCTTTCTCATTACTCTGGAGAAGAGAGGCTATGTGAAG GCTGGGCTCTGGACTCCAGAGGCAGTGATAGAACACCCAGACGCAGTTCGTCAACTTCAC ATGGAATTCTTGAGAGCAGGATCAAATGTCATGCAGACTTTTACCTTTTCTGCCAGTGAG GACAATATGGAAAGCAAGTATTTTGAGCACGTTGAAGAAGCTGTGTGGGCTGTGGAAGTC TTAAAAGAATCAGATAGACCCGTGGCAGTTACCATGTGCATAGGCCCAGAGGGAGACATG CATGATATAACCCCCGGAGAATGTGCTGTGAGGCTGGTGAAGGCAGGGGCTTCCATCGTT GGCGTGAACTGCCGCTTTGGGCCCGACACCAGCTTGAAGACGATGGAGCTCATGAAGGAG GGTCTTGAGTGGGCAGGGCTGAAAGCGCACCTCATGGTGCAGCCTCTGGGGTTCCACGCG CCTGACTGTGGCAAAGAGGGGTTTGTGGATCTCCCAGAATATCCCTTTGGACTGGAGTCC AGAGTTGCCACCAGATGGGATATTCAAAAATACGCCAGAGAGGCCTACAACCTGGGGGTC AGGTACATTGGCGGGTGCTGTGGATTTGAGCCCTACCACATCAGGGCAATTGCAGAGGAG CTGGCCCCAGAAAGGGGCTTTTTGCCACCAGCTTCAGAAAAACACGGCAGCTGGGGAAGT GGTTTGGACATGCACACCAAACCCTGGATTAGAGCAAGGGCTCGAAGGGAGTATTGGGAG AATCTGCTGCCAGCTTCAGGCAGACCTTTCTGTCCTTCGCTGTCAAAGCCAGACTTCTAA
- Chromosome Location
- 5
- Locus
- 5q13
- External Identifiers
Resource Link UniProtKB ID Q9H2M3 UniProtKB Entry Name BHMT2_HUMAN GenBank Protein ID 11907831 GenBank Gene ID AF257473 GenAtlas ID BHMT2 HGNC ID HGNC:1048 - General References
- Chadwick LH, McCandless SE, Silverman GL, Schwartz S, Westaway D, Nadeau JH: Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Genomics. 2000 Nov 15;70(1):66-73. [Article]
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