Beta,beta-carotene 15,15'-dioxygenase
Details
- Name
- Beta,beta-carotene 15,15'-dioxygenase
- Synonyms
- 1.13.11.63
- BCDO
- BCDO1
- BCMO1
- Beta-carotene dioxygenase 1
- Beta-carotene oxygenase 1
- Gene Name
- BCO1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051597|Beta,beta-carotene 15,15'-dioxygenase MDIIFGRNRKEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSF TIRDGEVYYRSKYLRSDTYNTNIEANRIVVSEFGTMAYPDPCKNIFSKAFSYLSHTIPDF TDNCLINIMKCGEDFYATSETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGN VLNMGTSIVEKGKTKYVIFKIPATVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFG VTENYVIFLEQPFRLDILKMATAYIRRMSWASCLAFHREEKTYIHIIDQRTRQPVQTKFY TDAMVVFHHVNAYEEDGCIVFDVIAYEDNSLYQLFYLANLNQDFKENSRLTSVPTLRRFA VPLHVDKNAEVGTNLIKVASTTATALKEEDGQVYCQPEFLYEGLELPRVNYAHNGKQYRY VFATGVQWSPIPTKIIKYDILTKSSLKWREDDCWPAEPLFVPAPGAKDEDDGVILSAIVS TDPQKLPFLLILDAKSFTELARASVDVDMHMDLHGLFITDMDWDTKKQAASEEQRDRASD CHGAPLT
- Number of residues
- 547
- Molecular Weight
- 62636.69
- Theoretical pI
- Not Available
- GO Classification
- Functionsbeta-carotene 15,15'-monooxygenase activity / metal ion bindingProcessesbeta-carotene metabolic process / retinal metabolic process / retinoid metabolic process / retinol metabolic process / vitamin A biosynthetic processComponentscytosol
- General Function
- Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism.
- Specific Function
- Beta-carotene 15,15'-monooxygenase activity
- Pfam Domain Function
- RPE65 (PF03055)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0051598|Beta,beta-carotene 15,15'-dioxygenase (BCO1) ATGGATATAATATTTGGCAGGAATAGGAAAGAACAGCTGGAGCCTGTGAGGGCCAAAGTG ACAGGCAAGATTCCAGCATGGCTGCAGGGAACCCTGCTCCGCAATGGGCCTGGGATGCAC ACAGTTGGGGAGTCCAGATACAACCATTGGTTCGACGGCCTTGCCCTGCTCCACAGCTTC ACCATCAGAGACGGTGAAGTCTATTACAGGAGCAAATACCTGAGAAGCGATACCTACAAC ACCAATATTGAGGCAAACAGGATTGTGGTGTCTGAGTTTGGAACAATGGCCTATCCGGAC CCCTGCAAAAACATATTTTCCAAAGCTTTCTCCTACTTGTCTCACACCATCCCCGATTTC ACCGACAACTGCCTGATCAACATCATGAAGTGCGGAGAAGACTTCTACGCGACCTCAGAG ACCAATTACATCAGGAAAATCAACCCACAGACTCTGGAAACCCTGGAGAAGGTTGATTAT CGTAAATACGTGGCGGTAAATCTGGCAACGTCACATCCCCATTATGATGAGGCTGGAAAT GTTCTAAACATGGGCACATCCATTGTGGAAAAGGGGAAGACAAAGTATGTGATTTTTAAG ATCCCTGCCACAGTACCAGAGGGCAAGAAGCAGGGGAAGAGCCCCTGGAAGCACACAGAG GTGTTCTGCTCCATCCCATCCCGCTCCCTGCTCTCCCCAAGCTACTACCACAGCTTTGGA GTCACCGAGAACTATGTCATCTTCCTTGAGCAGCCTTTCAGGTTGGATATTCTCAAGATG GCAACCGCATACATCCGGAGAATGAGCTGGGCCTCCTGCCTGGCTTTCCACAGGGAGGAG AAGACTTATATCCACATCATCGACCAAAGGACCAGGCAGCCTGTGCAGACCAAGTTTTAC ACAGACGCCATGGTGGTCTTCCATCACGTCAACGCCTACGAAGAGGACGGCTGCATCGTG TTTGACGTCATTGCCTACGAGGACAACAGCCTCTACCAGCTCTTCTACCTGGCCAACCTG AACCAGGACTTCAAGGAGAACTCCAGGCTCACCTCGGTCCCCACCCTCAGGAGGTTTGCC GTGCCCCTCCACGTGGACAAGAATGCAGAAGTGGGCACAAATTTAATCAAAGTGGCATCT ACAACAGCCACGGCCCTGAAGGAAGAAGATGGCCAAGTCTACTGCCAGCCGGAATTTCTT TATGAAGGCTTAGAGCTTCCACGGGTCAATTATGCTCACAATGGAAAGCAATACCGATAT GTCTTTGCTACAGGAGTTCAGTGGAGTCCAATCCCAACCAAGATAATAAAATATGACATT CTCACAAAGTCATCCTTAAAATGGAGAGAGGACGACTGCTGGCCAGCGGAACCCCTGTTT GTGCCCGCGCCAGGTGCCAAGGATGAGGATGACGGAGTAATCTTATCAGCCATTGTCTCT ACTGATCCCCAAAAGCTGCCTTTTCTGCTCATTCTGGATGCCAAAAGCTTTACGGAATTG GCCCGTGCCTCTGTTGATGTCGATATGCACATGGATCTCCATGGATTATTCATTACAGAC ATGGACTGGGACACAAAAAAGCAGGCCGCTTCTGAGGAACAGCGGGACAGGGCTTCCGAC TGCCACGGGGCTCCTCTGACCTGA
- Chromosome Location
- 16
- Locus
- 16q23.2
- External Identifiers
Resource Link UniProtKB ID Q9HAY6 UniProtKB Entry Name BCDO1_HUMAN HGNC ID HGNC:13815 - General References
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- dela Sena C, Riedl KM, Narayanasamy S, Curley RW Jr, Schwartz SJ, Harrison EH: The human enzyme that converts dietary provitamin A carotenoids to vitamin A is a dioxygenase. J Biol Chem. 2014 May 9;289(19):13661-6. doi: 10.1074/jbc.M114.557710. Epub 2014 Mar 25. [Article]
- Lindqvist A, Sharvill J, Sharvill DE, Andersson S: Loss-of-function mutation in carotenoid 15,15'-monooxygenase identified in a patient with hypercarotenemia and hypovitaminosis A. J Nutr. 2007 Nov;137(11):2346-50. doi: 10.1093/jn/137.11.2346. [Article]