Pleckstrin homology domain-containing family A member 1
Details
- Name
- Pleckstrin homology domain-containing family A member 1
- Synonyms
- PH domain-containing family A member 1
- Tandem PH domain-containing protein 1
- TAPP-1
- TAPP1
- Gene Name
- PLEKHA1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006361|Pleckstrin homology domain-containing family A member 1 MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIK LTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSD SQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLP YFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEV HKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS EHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQT VSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV
- Number of residues
- 404
- Molecular Weight
- 45553.165
- Theoretical pI
- 8.78
- GO Classification
- FunctionsPDZ domain binding / phosphatidylinositol-3,4-bisphosphate bindingProcessesandrogen metabolic process / B cell receptor signaling pathway / cellular response to hydrogen peroxide / establishment of protein localization / estrogen metabolic process / face morphogenesis / Leydig cell differentiation / luteinization / multicellular organism growth / negative regulation of protein kinase B signaling / palate development / phosphatidylinositol 3-kinase signaling / platelet-derived growth factor receptor signaling pathway / post-embryonic development / ruffle organization / skeletal system morphogenesis / spermatogenesisComponentscytoplasm / extracellular exosome / nucleoplasm / plasma membrane / ruffle membrane
- General Function
- Phosphatidylinositol-3,4-bisphosphate binding
- Specific Function
- Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
- Pfam Domain Function
- PH (PF00169)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019400|Pleckstrin homology domain-containing family A member 1 (PLEKHA1) ATGCCTTATGTGGATCGTCAGAATCGCATTTGTGGTTTTCTAGACATTGAAGAAAATGAA AACAGTGGGAAATTTCTTCGAAGGTACTTCATACTGGATACCAGAGAAGATAGTTTCGTG TGGTACATGGATAATCCACAGAACCTACCTTCTGGATCATCACGTGTTGGAGCCATTAAG CTTACCTACATTTCAAAGGTTAGCGATGCTACTAAGCTAAGGCCAAAGGCGGAGTTCTGT TTTGTTATGAATGCAGGAATGAGGAAGTACTTCCTACAAGCCAATGATCAGCAGGACCTA GTGGAATGGGTAAATGTGTTAAACAAAGCTATAAAAATTACAGTACCAAAGCAGTCAGAC TCACAGCCTAATTCTGATAACCTAAGTCGCCATGGTGAATGTGGGAAAAAGCAAGTGTCT TACAGAACTGATATTGTTGGTGGCGTACCCATCATTACTCCCACTCAGAAAGAAGAAGTA AATGAATGTGGTGAAAGTATTGACAGAAATAATCTGAAACGGTCACAAAGCCATCTTCCT TACTTTACTCCTAAACCACCTCAAGATAGTGCGGTTATCAAAGCTGGATATTGTGTAAAA CAAGGAGCAGTGATGAAAAACTGGAAGAGAAGATATTTTCAATTGGATGAAAACACAATA GGCTACTTCAAATCTGAACTGGAAAAGGAACCTCTTCGTGTAATACCACTTAAAGAGGTT CATAAAGTCCAGGAATGTAAGCAAAGCGACATAATGATGAGGGACAACCTCTTTGAAATT GTAACAACGTCTCGAACTTTCTATGTGCAGGCTGATAGCCCTGAAGAGATGCACAGTTGG ATTAAAGCAGTCTCTGGCGCCATTGTAGCACAGCGGGGTCCCGGCAGATCTGCGTCTTCT GAGCATCCCCCCGGTCCTTCAGAATCCAAACACGCTTTCCGTCCTACCAACGCAGCCACC GCCACCTCACATTCCACAGCCTCTCGCAGCAACTCTTTGGTCTCAACCTTTACCATGGAG AAGCGAGGATTTTACGAGTCTCTTGCCAAGGTCAAGCCAGGGAACTTCAAGGTCCAGACT GTCTCTCCAAGAGAACCAGCTTCCAAAGTGACTGAACAAGCTCTGTTAAGACCTCAAAGT AAAAATGGCCCTCAGGAAAAAGATTGTGACCTAGTAGACTTGGACGATGCGAGCCTTCCG GTCAGTGACGTGTGA
- Chromosome Location
- 10
- Locus
- 10q26.13
- External Identifiers
Resource Link UniProtKB ID Q9HB21 UniProtKB Entry Name PKHA1_HUMAN GenBank Gene ID AF286160 GenAtlas ID PLEKHA1 HGNC ID HGNC:14335 - General References
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