Nuclear receptor coactivator 5

Details

Name
Nuclear receptor coactivator 5
Synonyms
  • CIA
  • Coactivator independent of AF-2
  • KIAA1637
  • NCoA-5
Gene Name
NCOA5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0007751|Nuclear receptor coactivator 5
MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDL
RDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPM
YRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREEL
YRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQ
ALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNE
CREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEET
DKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPT
PSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQAS
GNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSV
QKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY
Number of residues
579
Molecular Weight
65535.8
Theoretical pI
9.93
GO Classification
Functions
chromatin binding / poly(A) RNA binding
Processes
glucose homeostasis / negative regulation of insulin receptor signaling pathway / regulation of transcription, DNA-templated / transcription, DNA-templated
Components
actin cytoskeleton / extracellular space / nucleus
General Function
Poly(a) rna binding
Specific Function
Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
Pfam Domain Function
Not Available
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0019515|Nuclear receptor coactivator 5 (NCOA5)
ATGAATACGGCTCCATCAAGACCCAGCCCCACACGAAGGGATCCATATGGCTTTGGAGAC
AGTCGAGATTCAAGGCGTGATCGATCCCCAATTCGAGGAAGTCCAAGGAGAGAGCCCAGG
GATGGCAGAAATGGCCGGGATGCCCGGGACAGCAGAGACATTCGAGACCCCCGAGACTTG
CGGGACCACAGACATAGTAGAGATTTGCGGGATCACAGAGACAGCAGGAGTGTGCGCGAC
GTTCGGGACGTGAGGGATCTTAGAGACTTTCGTGATCTAAGAGACTCTAGGGATTTTCGA
GATCAGCGAGACCCCATGTACGACAGATACAGAGACATGAGAGACTCCCGAGATCCTATG
TACAGGAGAGAAGGCTCTTATGACCGATACCTACGAATGGATGACTATTGCAGGAGAAAG
GATGACTCTTATTTTGACCGTTACAGAGATAGCTTTGATGGACGGGGCCCTCCAGGCCCA
GAAAGTCAGTCTCGTGCAAAAGAGCGTTTGAAACGTGAGGAACGGCGTAGAGAAGAGCTT
TATCGTCAATATTTTGAGGAAATCCAGAGACGCTTTGATGCCGAAAGGCCCGTTGATTGT
TCTGTGATTGTGGTCAACAAACAGACAAAAGACTATGCTGAGTCTGTGGGGCGGAAGGTG
CGAGACCTGGGCATGGTAGTGGACTTGATCTTCCTTAACACAGAAGTGTCACTGTCACAA
GCCTTGGAGGATGTTAGCAGGGGAGGTTCTCCTTTTGCTATTGTCATCACCCAGCAACAC
CAGATTCACCGCTCCTGCACAGTCAACATCATGTTTGGAACCCCGCAAGAGCATCGCAAC
ATGCCCCAAGCAGATGCCATGGTGCTGGTGGCCAGAAATTATGAGCGTTACAAGAATGAG
TGCCGGGAGAAGGAACGTGAGGAGATTGCCAGACAGGCAGCCAAGATGGCCGATGAAGCC
ATCCTGCAGGAAAGAGAGAGAGGAGGCCCTGAGGAGGGAGTGCGTGGGGGCCACCCTCCA
GCCATCCAGAGCCTCATCAACCTGCTGGCAGACAACAGGTACCTCACTGCTGAAGAGACT
GACAAGATCATCAACTACCTGCGAGAGCGGAAGGAGCGGCTGATGAGGAGCAGCACCGAC
TCTCTGCCTGGCCCGATTTCCCGCCAACCACTCGGGGCGACCTCGGGTGCCTCGCTGAAG
ACACAGCCAAGCTCCCAACCGCTCCAGAGCGGCCAAGTGCTCCCCTCTGCTACACCCACT
CCATCTGCACCCCCCACCTCCCAGCAAGAGCTTCAGGCCAAAATCCTCAGCCTCTTCAAT
AGTGGCACAGTGACGGCCAATAGCAGCTCTGCATCCCCCTCGGTTGCTGCCGGAAACACC
CCAAACCAGAATTTTTCCACAGCAGCAAACAGCCAGCCTCAACAAAGATCACAGGCTTCT
GGCAATCAGCCTCCAAGCATTTTGGGACAGGGAGGATCTGCTCAGAACATGGGCCCCAGA
CCTGGGGCTCCTTCCCAAGGGCTTTTTGGCCAGCCTTCCAGTCGCCTGGCACCTGCTAGC
AACATGACTAGCCAGAGGCCTGTGTCTTCCACAGGTATCAACTTTGACAATCCAAGTGTA
CAGAAGGCTCTGGATACCCTGATCCAGAGTGGCCCTGCTCTCTCCCACCTGGTTAGCCAG
ACCACAGCACAGATGGGGCAGCCACAGGCCCCCATGGGATCTTACCAGAGGCATTACTGA
Chromosome Location
20
Locus
20q12-q13.12
External Identifiers
ResourceLink
UniProtKB IDQ9HCD5
UniProtKB Entry NameNCOA5_HUMAN
GenBank Protein ID11526821
GenBank Gene IDAF230533
HGNC IDHGNC:15909
General References
  1. Sauve F, McBroom LD, Gallant J, Moraitis AN, Labrie F, Giguere V: CIA, a novel estrogen receptor coactivator with a bifunctional nuclear receptor interacting determinant. Mol Cell Biol. 2001 Jan;21(1):343-53. [Article]
  2. Jiang C, Ito M, Piening V, Bruck K, Roeder RG, Xiao H: TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. J Biol Chem. 2004 Jun 25;279(26):27781-9. Epub 2004 Apr 8. [Article]
  3. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Aug 31;7(4):273-81. [Article]
  6. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [Article]
  7. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [Article]
  8. Ulke-Lemee A, Trinkle-Mulcahy L, Chaulk S, Bernstein NK, Morrice N, Glover M, Lamond AI, Moorhead GB: The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G. Biochim Biophys Acta. 2007 Oct;1774(10):1339-50. Epub 2007 Aug 15. [Article]
  9. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
  10. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [Article]
  11. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
  12. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
  13. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  14. Rigbolt KT, Prokhorova TA, Akimov V, Henningsen J, Johansen PT, Kratchmarova I, Kassem M, Mann M, Olsen JV, Blagoev B: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal. 2011 Mar 15;4(164):rs3. doi: 10.1126/scisignal.2001570. [Article]
  15. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB0770217alpha-EstriolexperimentalunknownDetails