Nuclear receptor coactivator 5
Details
- Name
- Nuclear receptor coactivator 5
- Synonyms
- CIA
- Coactivator independent of AF-2
- KIAA1637
- NCoA-5
- Gene Name
- NCOA5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0007751|Nuclear receptor coactivator 5 MNTAPSRPSPTRRDPYGFGDSRDSRRDRSPIRGSPRREPRDGRNGRDARDSRDIRDPRDL RDHRHSRDLRDHRDSRSVRDVRDVRDLRDFRDLRDSRDFRDQRDPMYDRYRDMRDSRDPM YRREGSYDRYLRMDDYCRRKDDSYFDRYRDSFDGRGPPGPESQSRAKERLKREERRREEL YRQYFEEIQRRFDAERPVDCSVIVVNKQTKDYAESVGRKVRDLGMVVDLIFLNTEVSLSQ ALEDVSRGGSPFAIVITQQHQIHRSCTVNIMFGTPQEHRNMPQADAMVLVARNYERYKNE CREKEREEIARQAAKMADEAILQERERGGPEEGVRGGHPPAIQSLINLLADNRYLTAEET DKIINYLRERKERLMRSSTDSLPGPISRQPLGATSGASLKTQPSSQPLQSGQVLPSATPT PSAPPTSQQELQAKILSLFNSGTVTANSSSASPSVAAGNTPNQNFSTAANSQPQQRSQAS GNQPPSILGQGGSAQNMGPRPGAPSQGLFGQPSSRLAPASNMTSQRPVSSTGINFDNPSV QKALDTLIQSGPALSHLVSQTTAQMGQPQAPMGSYQRHY
- Number of residues
- 579
- Molecular Weight
- 65535.8
- Theoretical pI
- 9.93
- GO Classification
- Functionschromatin binding / poly(A) RNA bindingProcessesglucose homeostasis / negative regulation of insulin receptor signaling pathway / regulation of transcription, DNA-templated / transcription, DNA-templatedComponentsactin cytoskeleton / extracellular space / nucleus
- General Function
- Poly(a) rna binding
- Specific Function
- Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0019515|Nuclear receptor coactivator 5 (NCOA5) ATGAATACGGCTCCATCAAGACCCAGCCCCACACGAAGGGATCCATATGGCTTTGGAGAC AGTCGAGATTCAAGGCGTGATCGATCCCCAATTCGAGGAAGTCCAAGGAGAGAGCCCAGG GATGGCAGAAATGGCCGGGATGCCCGGGACAGCAGAGACATTCGAGACCCCCGAGACTTG CGGGACCACAGACATAGTAGAGATTTGCGGGATCACAGAGACAGCAGGAGTGTGCGCGAC GTTCGGGACGTGAGGGATCTTAGAGACTTTCGTGATCTAAGAGACTCTAGGGATTTTCGA GATCAGCGAGACCCCATGTACGACAGATACAGAGACATGAGAGACTCCCGAGATCCTATG TACAGGAGAGAAGGCTCTTATGACCGATACCTACGAATGGATGACTATTGCAGGAGAAAG GATGACTCTTATTTTGACCGTTACAGAGATAGCTTTGATGGACGGGGCCCTCCAGGCCCA GAAAGTCAGTCTCGTGCAAAAGAGCGTTTGAAACGTGAGGAACGGCGTAGAGAAGAGCTT TATCGTCAATATTTTGAGGAAATCCAGAGACGCTTTGATGCCGAAAGGCCCGTTGATTGT TCTGTGATTGTGGTCAACAAACAGACAAAAGACTATGCTGAGTCTGTGGGGCGGAAGGTG CGAGACCTGGGCATGGTAGTGGACTTGATCTTCCTTAACACAGAAGTGTCACTGTCACAA GCCTTGGAGGATGTTAGCAGGGGAGGTTCTCCTTTTGCTATTGTCATCACCCAGCAACAC CAGATTCACCGCTCCTGCACAGTCAACATCATGTTTGGAACCCCGCAAGAGCATCGCAAC ATGCCCCAAGCAGATGCCATGGTGCTGGTGGCCAGAAATTATGAGCGTTACAAGAATGAG TGCCGGGAGAAGGAACGTGAGGAGATTGCCAGACAGGCAGCCAAGATGGCCGATGAAGCC ATCCTGCAGGAAAGAGAGAGAGGAGGCCCTGAGGAGGGAGTGCGTGGGGGCCACCCTCCA GCCATCCAGAGCCTCATCAACCTGCTGGCAGACAACAGGTACCTCACTGCTGAAGAGACT GACAAGATCATCAACTACCTGCGAGAGCGGAAGGAGCGGCTGATGAGGAGCAGCACCGAC TCTCTGCCTGGCCCGATTTCCCGCCAACCACTCGGGGCGACCTCGGGTGCCTCGCTGAAG ACACAGCCAAGCTCCCAACCGCTCCAGAGCGGCCAAGTGCTCCCCTCTGCTACACCCACT CCATCTGCACCCCCCACCTCCCAGCAAGAGCTTCAGGCCAAAATCCTCAGCCTCTTCAAT AGTGGCACAGTGACGGCCAATAGCAGCTCTGCATCCCCCTCGGTTGCTGCCGGAAACACC CCAAACCAGAATTTTTCCACAGCAGCAAACAGCCAGCCTCAACAAAGATCACAGGCTTCT GGCAATCAGCCTCCAAGCATTTTGGGACAGGGAGGATCTGCTCAGAACATGGGCCCCAGA CCTGGGGCTCCTTCCCAAGGGCTTTTTGGCCAGCCTTCCAGTCGCCTGGCACCTGCTAGC AACATGACTAGCCAGAGGCCTGTGTCTTCCACAGGTATCAACTTTGACAATCCAAGTGTA CAGAAGGCTCTGGATACCCTGATCCAGAGTGGCCCTGCTCTCTCCCACCTGGTTAGCCAG ACCACAGCACAGATGGGGCAGCCACAGGCCCCCATGGGATCTTACCAGAGGCATTACTGA
- Chromosome Location
- 20
- Locus
- 20q12-q13.12
- External Identifiers
Resource Link UniProtKB ID Q9HCD5 UniProtKB Entry Name NCOA5_HUMAN GenBank Protein ID 11526821 GenBank Gene ID AF230533 HGNC ID HGNC:15909 - General References
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