Leukotriene B4 receptor 2

Details

Name
Leukotriene B4 receptor 2
Synonyms
  • BLT2R
  • BLTR2
  • Leukotriene B4 receptor BLT2
  • LTB4 receptor JULF2
  • LTB4-R 2
  • Seven transmembrane receptor BLTR2
Gene Name
LTB4R2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006761|Leukotriene B4 receptor 2
MAPSHRASQVGFCPTPERPLWRLPPTCRPRRMSVCYRPPGNETLLSWKTSRATGTAFLLL
AALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPL
GQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAA
LLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLR
GARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAA
RAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRT
TPQLKVVGQGRGNGDPGGGMEKDGPEWDL
Number of residues
389
Molecular Weight
41524.35
Theoretical pI
11.49
GO Classification
Functions
G-protein coupled peptide receptor activity / leukotriene B4 receptor activity / leukotriene receptor activity
Processes
chemotaxis / inflammatory response / keratinocyte migration / leukotriene signaling pathway / negative regulation of adenylate cyclase activity / neuropeptide signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathway
Components
integral component of plasma membrane / membrane / plasma membrane
General Function
Leukotriene receptor activity
Specific Function
Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3.
Pfam Domain Function
Transmembrane Regions
56-76 92-112 128-148 173-193 217-237 257-277 307-327
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0012432|Leukotriene B4 receptor 2 (LTB4R2)
ATGTCGGTCTGCTACCGTCCCCCAGGGAACGAGACACTGCTGAGCTGGAAGACTTCGCGG
GCCACAGGCACAGCCTTCCTGCTGCTGGCGGCGCTGCTGGGGCTGCCTGGCAACGGCTTC
GTGGTGTGGAGCTTGGCGGGCTGGCGGCCTGCACGGGGGCGACCGCTGGCGGCCACGCTT
GTGCTGCACCTGGCGCTGGCCGACGGCGCGGTGCTGCTGCTCACGCCGCTCTTTGTGGCC
TTCCTGACCCGGCAGGCCTGGCCGCTGGGCCAGGCGGGCTGCAAGGCGGTGTACTACGTG
TGCGCGCTCAGCATGTACGCCAGCGTGCTGCTCACCGGCCTGCTCAGCCTGCAGCGCTGC
CTCGCAGTCACCCGCCCCTTCCTGGCGCCTCGGCTGCGCAGCCCGGCCCTGGCCCGCCGC
CTGCTGCTGGCGGTCTGGCTGGCCGCCCTGTTGCTCGCCGTCCCGGCCGCCGTCTACCGC
CACCTGTGGAGGGACCGCGTATGCCAGCTGTGCCACCCGTCGCCGGTCCACGCCGCCGCC
CACCTGAGCCTGGAGACTCTGACCGCTTTCGTGCTTCCTTTCGGGCTGATGCTCGGCTGC
TACAGCGTGACGCTGGCACGGCTGCGGGGCGCCCGCTGGGGCTCCGGGCGGCACGGGGCG
CGGGTGGGCCGGCTGGTGAGCGCCATCGTGCTTGCCTTCGGCTTGCTCTGGGCCCCCTAC
CACGCAGTCAACCTTCTGCAGGCGGTCGCAGCGCTGGCTCCACCGGAAGGGGCCTTGGCG
AAGCTGGGCGGAGCCGGCCAGGCGGCGCGAGCGGGAACTACGGCCTTGGCCTTCTTCAGT
TCTAGCGTCAACCCGGTGCTCTACGTCTTCACCGCTGGAGATCTGCTGCCCCGGGCAGGT
CCCCGTTTCCTCACGCGGCTCTTCGAAGGCTCTGGGGAGGCCCGAGGGGGCGGCCGCTCT
AGGGAAGGGACCATGGAGCTCCGAACTACCCCTCAGCTGAAAGTGGTGGGGCAGGGCCGC
GGCAATGGAGACCCGGGGGGTGGGATGGAGAAGGACGGTCCGGAATGGGACCTTTGA
Chromosome Location
14
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9NPC1
UniProtKB Entry NameLT4R2_HUMAN
GenBank Gene IDAB083604
GenAtlas IDLTB4R2
HGNC IDHGNC:19260
General References
  1. Tryselius Y, Nilsson NE, Kotarsky K, Olde B, Owman C: Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. Biochem Biophys Res Commun. 2000 Aug 2;274(2):377-82. [Article]
  2. Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T: A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000 Aug 7;192(3):421-32. [Article]
  3. Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [Article]
  4. Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T: A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J Biol Chem. 2000 Dec 29;275(52):40686-94. [Article]
  5. Kamohara M, Takasaki J, Matsumoto M, Saito T, Ohishi T, Ishii H, Furuichi K: Molecular cloning and characterization of another leukotriene B4 receptor. J Biol Chem. 2000 Sep 1;275(35):27000-4. [Article]
  6. Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S: Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 2002 Jun 5;520(1-3):97-101. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06248AmelubantinvestigationalunknownDetails
DB12961Leukotriene B4investigationalunknownDetails