Inositol-3-phosphate synthase 1

Details

Name
Inositol-3-phosphate synthase 1
Synonyms
  • 5.5.1.4
  • hINO1
  • hIPS
  • INO1
  • IPS 1
  • MI-1-P synthase
  • MIP synthase
  • Myo-inositol 1-phosphate synthase
  • Myo-inositol 1-phosphate synthase A1
Gene Name
ISYNA1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0009417|Inositol-3-phosphate synthase 1
MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLG
VMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVF
VPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYI
PEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPG
LNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVG
GDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVV
DDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDS
LLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALF
RQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNG
CTGDANGHLQEEPPMPTT
Number of residues
558
Molecular Weight
61067.285
Theoretical pI
Not Available
GO Classification
Functions
inositol-3-phosphate synthase activity
Processes
inositol biosynthetic process / inositol phosphate metabolic process / phospholipid biosynthetic process / small molecule metabolic process
Components
cytosol
General Function
Inositol-3-phosphate synthase activity
Specific Function
Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0013145|Inositol-3-phosphate synthase 1 (ISYNA1)
ATGGAGGCCGCCGCCCAGTTCTTCGTCGAGAGCCCGGACGTGGTCTACGGCCCCGAGGCC
ATCGAGGCGCAATACGAGTACCGGACGACGCGCGTCAGCCGCGAGGGTGGCGTTCTCAAG
GAGGCCAACTACTACGGCTCGCTGACTCAGGCGGGCACCGTGAGCCTGGGCCTGGACGCC
GAGGGCCAGGAGGTGTTCGTACCCTTCAGCGCGGTGCTGCCCATGGTGGCGCCCAACGAC
CTCGTGTTCGATGGCTGGGACATCTCGTCGCTGAACCTGGCCGAGGCGATGCGGCGCGCG
AAGGTGCTGGACTGGGGGCTGCAGGAGCAACTGTGGCCGCACATGGAGGCCCTGCGGCCC
CGGCCTTCTGTTTACATCCCCGAATTCATCGCGGCCAACCAGAGCGCGCGCGCGGACAAC
CTCATCCCAGGCTCGCGTGCGCAGCAGCTGGAGCAGATCCGCAGGGACATCCGAGACTTC
CGGTCTAGCGCGGGGCTGGACAAAGTCATAGTGCTGTGGACGGCGAACACGGAGCGCTTC
TGTGAGGTGATTCCAGGCCTCAACGACACAGCCGAGAACCTGCTGCGCACCATTGAGCTC
GGTCTGGAGGTGTCGCCCTCCACGCTCTTCGCCGTGGCCAGCATCCTGGAGGGCTGTGCC
TTCCTCAATGGGTCTCCGCAGAACACCCTGGTGCCCGGAGCTCTTGAGCTCGCGTGGCAG
CACCGGGTTTTTGTGGGCGGAGATGACTTCAAGTCAGGCCAGACCAAAGTCAAGTCCGTG
CTTGTGGACTTCCTCATTGGCTCCGGCCTCAAGACCATGTCCATCGTGAGTTACAACCAC
CTGGGCAACAACGATGGGGAGAACCTATCGGCGCCATTGCAGTTCCGCTCTAAGGAGGTG
TCCAAGAGCAACGTGGTGGACGACATGGTGCAGAGCAACCCAGTGCTCTATACGCCCGGC
GAAGAGCCTGACCACTGCGTGGTCATCAAGTATGTGCCGTACGTGGGTGACAGCAAGCGC
GCGCTGGATGAGTATACCTCGGAGCTGATGCTGGGCGGAACCAACACACTGGTGCTGCAC
AACACGTGTGAGGACTCGCTGCTGGCCGCACCCATCATGCTGGACCTAGCGCTGCTGACC
GAGCTGTGCCAGCGCGTGAGCTTCTGCACTGACATGGACCCCGAGCCGCAGACCTTCCAC
CCCGTGCTGTCCCTGCTCAGCTTCCTCTTCAAGGCGCCACTAGTGCCGCCCGGCAGCCCG
GTGGTCAATGCGCTTTTCCGCCAGCGCAGCTGCATCGAGAACATCCTCAGGGCCTGCGTG
GGGCTCCCGCCACAGAACCACATGCTCCTGGAACACAAAATGGAGCGCCCAGGGCCCAGC
CTCAAGCGAGTTGGACCCGTGGCTGCCACCTACCCTATGTTGAACAAGAAAGGACCGGTA
CCCGCTGCCACCAATGGCTGCACCGGTGATGCCAATGGGCATCTGCAAGAGGAGCCCCCA
ATGCCCACCACCTGA
Chromosome Location
19
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9NPH2
UniProtKB Entry NameINO1_HUMAN
HGNC IDHGNC:29821
General References
  1. Guan G, Dai P, Shechter I: cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase. Arch Biochem Biophys. 2003 Sep 15;417(2):251-9. [Article]
  2. Parthasarathy LK, Seelan RS, Tobias C, Casanova MF, Parthasarathy RN: Mammalian inositol 3-phosphate synthase: its role in the biosynthesis of brain inositol and its clinical use as a psychoactive agent. Subcell Biochem. 2006;39:293-314. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
  5. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Seelan RS, Parthasarathy LK, Parthasarathy RN: E2F1 regulation of the human myo-inositol 1-phosphate synthase (ISYNA1) gene promoter. Arch Biochem Biophys. 2004 Nov 1;431(1):95-106. [Article]
  8. Ju S, Shaltiel G, Shamir A, Agam G, Greenberg ML: Human 1-D-myo-inositol-3-phosphate synthase is functional in yeast. J Biol Chem. 2004 May 21;279(21):21759-65. Epub 2004 Mar 15. [Article]
  9. Shamir A, Shaltiel G, Mark S, Bersudsky Y, Belmaker RH, Agam G: Human MIP synthase splice variants in bipolar disorder. Bipolar Disord. 2007 Nov;9(7):766-71. [Article]
  10. Shaltiel G, Mark S, Kofman O, Belmaker RH, Agam G: Effect of valproate derivatives on human brain myo-inositol-1-phosphate (MIP) synthase activity and amphetamine-induced rearing. Pharmacol Rep. 2007 Jul-Aug;59(4):402-7. [Article]
  11. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB018402-Deoxy-D-Glucitol 6-(E)-VinylhomophosphonateexperimentalunknownDetails
DB09462Glycerinapproved, investigationalunknownDetails
DB045162-Deoxy-Glucitol-6-PhosphateexperimentalunknownDetails